scholarly journals Tumor DNA‐Methylome derived Epigenetic Fingerprint Identifies HPV ‐negative Head and Neck Patients at Risk for Locoregional Recurrence after Postoperative Radiochemotherapy

2021 ◽  
Author(s):  
Bouchra Tawk ◽  
Ute Wirkner ◽  
Christian Schwager ◽  
Katrin Rein ◽  
Karim Zaoui ◽  
...  
Keyword(s):  
At Risk ◽  
Head And Neck ◽  
Locoregional Recurrence ◽  
Dna Methylome ◽  
Patients At Risk ◽  
Postoperative Radiochemotherapy ◽  
Tumor Dna

scholarly journals Assessment of cough in head and neck cancer patients at risk for dysphagia—An overview

2021 ◽  
Author(s):  
Sofiana Mootassim‐Billah ◽  
Gwen Van Nuffelen ◽  
Jean Schoentgen ◽  
Marc De Bodt ◽  
Tatiana Dragan ◽  
...  
Keyword(s):  
At Risk ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Patients At Risk

Can Predictive Modeling Identify Head and Neck Oncology Patients at Risk for Readmission?

2018 ◽  
Vol 159 (4) ◽  
pp. 669-674 ◽  
Author(s):  
Amy M. Manning ◽  
Keith A. Casper ◽  
Kay St. Peter ◽  
Keith M. Wilson ◽  
Jonathan R. Mark ◽  
...  
Keyword(s):  
At Risk ◽  
Head And Neck ◽  
Predictive Modeling ◽  
Head And Neck Oncology ◽  
Oncology Patients ◽  
Patients At Risk

scholarly journals Proton Beam Therapy for Head and Neck Carcinoma of Unknown Primary: Toxicity and Quality of Life

2021 ◽  
Vol 8 (1) ◽  
pp. 234-247
Author(s):  
Alexander D. Sherry ◽  
Dario Pasalic ◽  
G. Brandon Gunn ◽  
C. David Fuller ◽  
Jack Phan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
At Risk ◽  
Head And Neck ◽  
Head And Neck Carcinoma ◽  
Unknown Primary ◽  
Carcinoma Of Unknown Primary ◽  
Neck Carcinoma ◽  
Patients At Risk ◽  
Md Anderson

Abstract Purpose Proton radiation therapy (PRT) may offer dosimetric and clinical benefit in the treatment of head and neck carcinoma of unknown primary (HNCUP). We sought to describe toxicity and quality of life (QOL) in patients with HNCUP treated with PRT. Patients and Methods Toxicity and QOL were prospectively tracked in patients with HNCUP from 2011 to 2019 after institutional review board approval. Patients received PRT to the mucosa of the nasopharynx, oropharynx, and bilateral cervical lymph nodes with sparing of the larynx and hypopharynx. Patient-reported outcomes were tracked with the MD Anderson Symptom Inventory–Head and Neck Module, the Functional Assessment of Cancer Therapy–Head and Neck, the MD Anderson Dysphagia Inventory, and the Xerostomia-Related QOL Scale. Primary study endpoints were the incidence of grade ≥ 3 (G3) toxicity and QOL patterns. Results Fourteen patients (median follow-up, 2 years) were evaluated. Most patients presented with human papillomavirus–positive disease (n = 12, 86%). Rates of G3 oral mucositis, xerostomia, and dermatitis were 7% (n = 1), 21% (n = 3), and 36% (n = 5), respectively. None required a gastrostomy. During PRT, QOL was reduced relative to baseline and recovered shortly after PRT. At 2 years after PRT, the local regional control, disease-free survival, and overall survival were 100% (among 7 patients at risk), 79% (among 6 patients at risk), and 90% (among 7 patients at risk), respectively. Conclusion Therefore, PRT for HNCUP was associated with highly favorable dosimetric and clinical outcomes, including minimal oral mucositis, xerostomia, and dysphagia. Toxicity and QOL may be superior with PRT compared with conventional radiation therapy and PRT maintains equivalent oncologic control. Further prospective studies are needed to evaluate late effects and cost-effectiveness.

scholarly journals Preoperative identification of patients at risk for delirium after major head and neck cancer surgery

1995 ◽  
Vol 105 (10) ◽  
pp. 1066-1068 ◽  
Author(s):  
Harrison G. Weed ◽  
Christopher V. Lutman ◽  
Donn C. Young ◽  
David E. Schuller
Keyword(s):  
At Risk ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Cancer Surgery ◽  
Patients At Risk

A Predictive Model for Wound Sepsis in Oncologic Surgery of the Head and Neck

1987 ◽  
Vol 96 (2) ◽  
pp. 165-171 ◽  
Author(s):  
Randolph R. Cole ◽  
K. Thomas Robbins ◽  
James I. Cohen ◽  
Patricia F. Wolf
Keyword(s):  
At Risk ◽  
Wound Infection ◽  
Head And Neck ◽  
Predictive Model ◽  
Concomitant Disease ◽  
Postoperative Wound Infection ◽  
Oncologic Surgery ◽  
Postoperative Wound ◽  
Patients At Risk ◽  
Clean Contaminated

A prospective analysis of patients undergoing surgical resection of squamous cell carcinoma of the upper aerodigestive tract was performed in order to identify the patients at risk of postoperative wound infection and to develop a model predictive of wound infection. Fifty-nine patients who underwent extirpative clean-contaminated procedures—all of whom received cefazolin as the sole chemoprophylactic agent, were studied over a 1-year period. Twenty-three variables were recorded for each patient in the study. The overall rate of wound infection was 25.4%. Univariate analysis indicated that three variables were significantly related to the likelihood of postoperative wound infection. These included tumor stage (P = 0.0180), nodal stage (P = 0.0062), and duration of surgery (P = 0.0151). The Biomedical Computer Program (BMDP), a logistic regression program specifically designed for a binary dependent variable (infection vs. no infection) based on independent variables that may be continuous or categorical, was used in development of a model predictive of wound infection. T-stage, N-stage, and the presence of concomitant disease made up the combination of factors found to be most predictive of infection in our study population. Considering “success” to be the development of infection if the probability was 75% or higher, and the absence of infection if the probability was less than 25%, the multiple regression analysis model demonstrated a predictive success rate of 74.6%. Our results indicate that the risk of infection in patients undergoing clean-contaminated oncologic surgery of the head and neck is greatest for patients who have advanced disease that requires prolonged surgery in the presence of concomitant diseases. The correlates and predictive model generated by this study can be used as assurance that patients at risk for postoperative infection have been appropriately randomized in future prospective antibiotic trials planned at this institution.

1678: Identifying Patients at Risk for Benign Versus Life Shortening Postoperative Prostate-Specific Antigen Failure

2005 ◽  
Vol 173 (4S) ◽  
pp. 455-455
Author(s):  
Anthony V. D’Amico ◽  
Ming-Hui Chen ◽  
Kimberly A. Roehl ◽  
William J. Catalona
Keyword(s):  
At Risk ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Patients At Risk
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