Association between fish oil supplementation and cancer risk according to fatty fish consumption: A large prospective population‐based cohort study using UK Biobank

2021 ◽  
Author(s):  
Zheran Liu ◽  
Yaxin Luo ◽  
Jianjun Ren ◽  
Lianlian Yang ◽  
Juejin Li ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Fish Oil ◽  
Fish Consumption ◽  
Population Based ◽  
Uk Biobank ◽  
Fatty Fish ◽  
Fish Oil Supplementation

scholarly journals Associations of habitual fish oil supplementation with cardiovascular outcomes and all cause mortality: evidence from a large population based cohort study

BMJ ◽  
2020 ◽  
pp. m456 ◽  
Author(s):  
Zhi-Hao Li ◽  
Wen-Fang Zhong ◽  
Simin Liu ◽  
Virginia Byers Kraus ◽  
Yu-Jie Zhang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Fish Oil ◽  
Prospective Cohort ◽  
Large Population ◽  
Population Based ◽  
Marginal Benefit ◽  
Hazard Ratios ◽  
All Cause Mortality ◽  
Fish Oil Supplementation ◽  
Cvd Mortality

Abstract Objectives To evaluate the associations of habitual fish oil supplementation with cardiovascular disease (CVD) and mortality in a large prospective cohort. Design Population based, prospective cohort study. Setting UK Biobank. Participants A total of 427 678 men and women aged between 40 and 69 who had no CVD or cancer at baseline were enrolled between 2006 and 2010 and followed up to the end of 2018. Main exposure All participants answered questions on the habitual use of supplements, including fish oil. Main outcome measures All cause mortality, CVD mortality, and CVD events. Results At baseline, 133 438 (31.2%) of the 427 678 participants reported habitual use of fish oil supplements. The multivariable adjusted hazard ratios for habitual users of fish oil versus non-users were 0.87 (95% confidence interval 0.83 to 0.90) for all cause mortality, 0.84 (0.78 to 0.91) for CVD mortality, and 0.93 (0.90 to 0.96) for incident CVD events. For CVD events, the association seemed to be stronger among those with prevalent hypertension (P for interaction=0.005). Conclusions Habitual use of fish oil seems to be associated with a lower risk of all cause and CVD mortality and to provide a marginal benefit against CVD events among the general population.

Endometrial cancer risk after fertility treatment: a population-based cohort study

2021 ◽  
Author(s):  
Sonia Guleria ◽  
Allan Jensen ◽  
Vanna Albieri ◽  
Bugge Nøhr ◽  
Kirsten Frederiksen ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Fertility Treatment ◽  
Endometrial Cancer Risk

scholarly journals Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants

Diabetologia ◽  
2021 ◽  
Author(s):  
Ziyi Zhou ◽  
John Macpherson ◽  
Stuart R. Gray ◽  
Jason M. R. Gill ◽  
Paul Welsh ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Respiratory Diseases ◽  
Population Based ◽  
Incident Diabetes ◽  
Uk Biobank ◽  
Metabolically Healthy Obesity ◽  
Wide Range ◽  
Metabolically Healthy

Abstract Aims/hypothesis People with obesity and a normal metabolic profile are sometimes referred to as having ‘metabolically healthy obesity’ (MHO). However, whether this group of individuals are actually ‘healthy’ is uncertain. This study aims to examine the associations of MHO with a wide range of obesity-related outcomes. Methods This is a population-based prospective cohort study of 381,363 UK Biobank participants with a median follow-up of 11.2 years. MHO was defined as having a BMI ≥ 30 kg/m2 and at least four of the six metabolically healthy criteria. Outcomes included incident diabetes and incident and fatal atherosclerotic CVD (ASCVD), heart failure (HF) and respiratory diseases. Results Compared with people who were not obese at baseline, those with MHO had higher incident HF (HR 1.60; 95% CI 1.45, 1.75) and respiratory disease (HR 1.20; 95% CI 1.16, 1.25) rates, but not higher ASCVD. The associations of MHO were generally weaker for fatal outcomes and only significant for all-cause (HR 1.12; 95% CI 1.04, 1.21) and HF mortality rates (HR 1.44; 95% CI 1.09, 1.89). However, when compared with people who were metabolically healthy without obesity, participants with MHO had higher rates of incident diabetes (HR 4.32; 95% CI 3.83, 4.89), ASCVD (HR 1.18; 95% CI 1.10, 1.27), HF (HR 1.76; 95% CI 1.61, 1.92), respiratory diseases (HR 1.28; 95% CI 1.24, 1.33) and all-cause mortality (HR 1.22; 95% CI 1.14, 1.31). The results with a 5 year landmark analysis were similar. Conclusions/interpretation Weight management should be recommended to all people with obesity, irrespective of their metabolic status, to lower risk of diabetes, ASCVD, HF and respiratory diseases. The term ‘MHO’ should be avoided as it is misleading and different strategies for risk stratification should be explored. Graphical abstract

Alcoholism and cancer risk: a population-based cohort study

1992 ◽  
Vol 3 (5) ◽  
pp. 419-425 ◽  
Author(s):  
Hans-Olov Adami ◽  
Joseph K. McLaughlin ◽  
Ann W. Hsing ◽  
Alicja Wolk ◽  
Anders Ekbom ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Population Based

Cancer risk in patients with Behçet disease: A nationwide population-based dynamic cohort study from Korea

2018 ◽  
Vol 78 (3) ◽  
pp. 464-470.e2 ◽  
Author(s):  
Sae Jung Na ◽  
Min Ji Kang ◽  
Dong Soo Yu ◽  
Kyung-Do Han ◽  
Ji Hyun Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cancer Risk ◽  
Population Based ◽  
Behçet Disease ◽  
Behcet Disease

Cancer Risk in Inflammatory Bowel Disease According to Patient Phenotype and Treatment: A Danish Population-Based Cohort Study

2013 ◽  
Vol 108 (12) ◽  
pp. 1869-1876 ◽  
Author(s):  
Tine Jess ◽  
Erzsébet Horváth-Puhó ◽  
Jan Fallingborg ◽  
Henrik H Rasmussen ◽  
Bent A Jacobsen
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cohort Study ◽  
Cancer Risk ◽  
Bowel Disease ◽  
Population Based ◽  
Danish Population ◽  
Inflammatory Bowel

scholarly journals Occupations associated with COPD risk in the large population-based UK Biobank cohort study

2016 ◽  
Vol 73 (6) ◽  
pp. 378-384 ◽  
Author(s):  
Sara De Matteis ◽  
Deborah Jarvis ◽  
Sally Hutchings ◽  
Andy Darnton ◽  
David Fishwick ◽  
...  
Keyword(s):  
Cohort Study ◽  
Large Population ◽  
Population Based ◽  
Uk Biobank
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