High serum uric acid may associate with the increased risk of colorectal cancer in females: A prospective cohort study

2021 ◽  
Author(s):  
Ningning Mi ◽  
Junjun Huang ◽  
Chongfei Huang ◽  
Yanyan Lin ◽  
Qiangsheng He ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
High Serum ◽  
Increased Risk

Serum Uric Acid Levels and Their Changes and Risk of Stroke: A 7-Year Prospective Cohort Study in Northwest China

2021 ◽  
pp. 1-10
Author(s):  
Shan Zheng ◽  
Yan Luo ◽  
Qian Miao ◽  
Zhiyuan Cheng ◽  
Yanli Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Reference Group ◽  
Northwest China ◽  
Stroke Incidence ◽  
Increased Risk ◽  
Over Time

<b><i>Introduction:</i></b> It is not clear whether serum uric acid (SUA) levels and their changes over time are associated with the risk of stroke. A 7-year prospective cohort study in northwest China was conducted to analyze effects of SUA and their changes on the risk of stroke. <b><i>Methods:</i></b> A total of 23,262 individuals without cardiovascular disease in the Jinchang cohort were followed up for an average of 5.26 years. The Cox proportional hazard model was used to estimate the hazard ratios (HRs) and 95% confidence interval (95% CI) of stroke incidence to SUA and relative changes in SUA. Sensitivity analysis was performed after controlling the effect of renal insufficiency. <b><i>Results:</i></b> Baseline SUA and relative changes in SUA were positively correlated with the incidence of stroke in both males and females (<i>p</i> for overall association &#x3c;0.0001). Stroke risk increased by 4.6% per 10% increase in the relative change of SUA (HR = 1.046, 95% CI, 1.007–1.086). The fully adjusted regression analysis demonstrated that only the large gain (&#x3e;30%) in SUA was associated with an increased risk of stroke by 36.5% (95% CI, 1.8–83.0%), compared with the reference group (participants within ±10% changes in SUA). The same trend was observed in people with normal baseline SUA. In the unadjusted model, the risk of stroke associated with elevated SUA was significantly higher in the hyperuricemia group than in the normal SUA group. <b><i>Conclusion:</i></b> High initial SUA concentration and an increase in SUA concentration over time would increase the risk of stroke, and this means that there is no safe increase in SUA.

scholarly journals Serum uric acid is associated with increased risk of posttransplantation diabetes in kidney transplant recipients: a prospective cohort study

Metabolism ◽  
2021 ◽  
Vol 116 ◽  
pp. 154465
Author(s):  
Camilo G. Sotomayor ◽  
Sara Sokooti Oskooei ◽  
Nicolás I. Bustos ◽  
Ilja M. Nolte ◽  
António W. Gomes-Neto ◽  
...  
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Kidney Transplant ◽  
Serum Uric Acid ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Increased Risk

scholarly journals Serum uric acid levels and risk of kidney cancer incidence and mortality: A prospective cohort study

2020 ◽  
Vol 9 (15) ◽  
pp. 5655-5661
Author(s):  
Xiao‐Yu Dai ◽  
Qiang‐Sheng He ◽  
Zhong Jing ◽  
Jin‐Qiu Yuan
Keyword(s):  
Uric Acid ◽  
Cohort Study ◽  
Serum Uric Acid ◽  
Kidney Cancer ◽  
Prospective Cohort Study ◽  
Cancer Incidence ◽  
Prospective Cohort ◽  
Incidence And Mortality

scholarly journals Quality and outcomes in global cancer surgery: protocol for a multicentre, international, prospective cohort study (GlobalSurg 3)

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e026646 ◽  
Author(s):  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Observational Data ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Cancer Surgery ◽  
Risk Of Death ◽  
Low Middle Income Countries ◽  
Increased Risk ◽  
Quality And Outcomes

IntroductionEmpirical, observational data relating to the diagnosis, management and outcome of three common worldwide cancers requiring surgery is lacking. However, it has been demonstrated that patients in low/middle-income countries undergoing surgery for cancer are at increased risk of death and major complications postoperatively. This study aims to determine quality and outcomes in breast, gastric and colorectal cancer surgery across worldwide hospital settings.Methods and analysisThis multicentre, international prospective cohort study will be undertaken by any hospital providing emergency or elective surgical services for breast, gastric or colorectal cancer. Centres will collect observational data on consecutive patients undergoing primary emergency or elective surgery for breast, gastric or colorectal cancer during a 6-month period. The primary outcome is the incidence of mortality and major complication rate at 30 days after cancer surgery. Infrastructure and care processes in the treatment of these cancers worldwide will also be characterised.Ethics and disseminationThis project will not affect clinical practice and has been classified as clinical audit following research ethics review. The protocol will be disseminated through the international GlobalSurg network.Trial registration numberNCT03471494; Pre-results.

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