Mortality risk among 5‐year survivors of childhood cancer in Germany—Results from the CVSS study (Cardiac and Vascular late Sequelae in long‐term Survivors of childhood cancer study)

2021 ◽  
Author(s):  
Hiltrud Merzenich ◽  
Dan Baaken ◽  
Astrid Schneider ◽  
Marie A. Neu ◽  
Arthur Wingerter ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Mortality Risk ◽  
Late Sequelae ◽  
Cancer Study ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Prevalence of cardiovascular late sequelae in long-term survivors of childhood cancer: A systematic review and meta-analysis

2017 ◽  
Vol 64 (7) ◽  
pp. e26428 ◽  
Author(s):  
Peter Scholz-Kreisel ◽  
Claudia Spix ◽  
Maria Blettner ◽  
Susan Eckerle ◽  
Jörg Faber ◽  
...  
Keyword(s):  
Systematic Review ◽  
Childhood Cancer ◽  
Meta Analysis ◽  
Late Sequelae ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

scholarly journals No evidence of overweight in long-term survivors of childhood cancer after glucocorticoid treatment

Cancer ◽  
2018 ◽  
Vol 124 (17) ◽  
pp. 3576-3585 ◽  
Author(s):  
Fabiën N. Belle ◽  
Rahel Kasteler ◽  
Christina Schindera ◽  
Murielle Bochud ◽  
Roland A. Ammann ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Glucocorticoid Treatment ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Abstract 5949: Abnormal NT-Pro-BNP Levels in Asymptomatic Long Term Survivors of Childhood Cancer Treated with Anthracyclines

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Annelies M Mavinkurve-Groothuis ◽  
Jacqueline Groot-Loonen ◽  
Louise Bellersen ◽  
Milanthy S Pourier ◽  
Ton Feuth ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Late Onset ◽  
Troponin T ◽  
Plasma Concentrations ◽  
Left Ventricular ◽  
Internal Diameter ◽  
List Type ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Objectives : to document plasma concentrations of cardiac Troponin T (cTnT) and NT-pro-brain natriuretic peptide (NT-pro-BNP) in a large group of asymptomatic long term survivors of childhood cancer treated with anthracyclines, to study the relation of the abnormal biomarker levels with different risk factors for anthracycline-induced cardiotoxicity and conventional echocardiographic parameters. Methods : 122 asymptomatic survivors of childhood cancer underwent a detailed echocardiography. Blood samples were taken to determine the levels of NT-pro-BNP and cTnT. Results : None of the survivors had abnormal cTnT levels. The mean NT-pro-BNP level of our survivor group was 10 pmol/l (SD±9) with a range of 1–55 pmol/l. Thirteen percent of the survivors had abnormal NT-pro-BNP levels. Abnormal NT-pro-BNP levels were significantly related to cumulative anthracycline dosage (p<0.003). Eleven of 31 (35%) survivors treated with cumulative anthracycline dose of 300 mg/m 2 or more, had abnormal NT-pro-BNP levels which were significantly related to end-diastolic left ventricular internal diameter (LVIDd) indexed for body surface area (BSA) (p<0.01). Conclusion : Cardiac TnT does not contribute to the early detection of late onset anthracyline-induced cardiotoxicity. Abnormal levels of NT-pro-BNP were frequently detected in asymptomatic, long term survivors of childhood cancer. Follow up of these survivors, with both echocardiography and NT-pro-BNP, is essential to answer the question whether NT-pro-BNP is an early marker for late onset anthracycline-induced cardiotoxicity.

scholarly journals Diabetes Mellitus in Long-term Survivors of Childhood Cancer

2009 ◽  
Vol 169 (15) ◽  
pp. 1381 ◽  
Author(s):  
Lillian R. Meacham ◽  
Charles A. Sklar ◽  
Suwen Li ◽  
Qi Liu ◽  
Nora Gimpel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Childhood Cancer ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

scholarly journals Occurrence of Multiple Subsequent Neoplasms in Long-Term Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

2011 ◽  
Vol 29 (22) ◽  
pp. 3056-3064 ◽  
Author(s):  
Gregory T. Armstrong ◽  
Wei Liu ◽  
Wendy Leisenring ◽  
Yutaka Yasui ◽  
Sue Hammond ◽  
...  
Keyword(s):  
Childhood Cancer ◽  
Cumulative Incidence ◽  
Malignant Neoplasm ◽  
Childhood Cancer Survivors ◽  
Late Morbidity ◽  
Childhood Cancer Survivor Study ◽  
Survivors Of Childhood Cancer ◽  
Long Term Survivors

Purpose Childhood cancer survivors experience an increased incidence of subsequent neoplasms (SNs). Those surviving the first SN (SN1) remain at risk to develop multiple SNs. Because SNs are a common cause of late morbidity and mortality, characterization of rates of multiple SNs is needed. Patients and Methods In a total of 14,358 5-year survivors of childhood cancer diagnosed between 1970 and 1986, analyses were carried out among 1,382 survivors with an SN1. Cumulative incidence of second subsequent neoplasm (SN2), either malignant or benign, was calculated. Results A total of 1,382 survivors (9.6%) developed SN1, of whom 386 (27.9%) developed SN2. Of those with SN2, 153 (39.6%) developed more than two SNs. Cumulative incidence of SN2 was 46.9% (95% CI, 41.6% to 52.2%) at 20 years after SN1. The cumulative incidence of SN2 among radiation-exposed survivors was 41.3% (95% CI, 37.2% to 45.4%) at 15 years compared with 25.7% (95% CI, 16.5% to 34.9%) for those not treated with radiation. Radiation-exposed survivors who developed an SN1 of nonmelanoma skin cancer (NMSC) had a cumulative incidence of subsequent malignant neoplasm (SMN; ie, malignancies excluding NMSC) of 20.3% (95% CI, 13.0% to 27.6%) at 15 years compared with only 10.7% (95% CI, 7.2% to 14.2%) for those who were exposed to radiation and whose SN1 was an invasive SMN (excluding NMSC). Conclusion Multiple SNs are common among aging survivors of childhood cancer. SN1 of NMSC identifies a population at high risk for invasive SMN. Survivors not exposed to radiation who develop multiple SNs represent a population of interest for studying genetic susceptibility to neoplasia.

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