scholarly journals Outcome of the randomized control screening trials on Oral, Cervix and Breast Cancer from India and way forward in COVID ‐19 pandemic situation

2021 ◽  
Author(s):  
Atul Budukh ◽  
Rajesh Dikshit ◽  
Pankaj Chaturvedi
Keyword(s):  
Breast Cancer ◽  
Randomized Control ◽  
Screening Trials

Online couples mindfulness-based intervention for young breast cancer survivors and their partners: A randomized-control trial

2020 ◽  
Vol 38 (5) ◽  
pp. 592-611 ◽  
Author(s):  
Mollie A. Price-Blackshear ◽  
Steven D. Pratscher ◽  
Danielle L. Oyler ◽  
Jane M. Armer ◽  
An-Lin Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Randomized Control Trial ◽  
Breast Cancer Survivors ◽  
Randomized Control ◽  
Young Breast Cancer

scholarly journals Breast Cancer Screening Trials: Endpoints and Overdiagnosis

2020 ◽  
Author(s):  
Ismail Jatoi ◽  
Paul F Pinsky
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Breast Cancer Screening ◽  
Cancer Detection ◽  
Primary Endpoint ◽  
Tumor Detection ◽  
Breast Cancer Detection ◽  
Detection Rates ◽  
Screening Strategies ◽  
Screening Trials

Abstract Screening mammography was assessed in 9 randomized trials initiated between 1963 and 1990, with breast cancer-specific mortality as the primary endpoint. In contrast, breast cancer detection has been the primary endpoint in most screening trials initiated during the past decade. These trials have evaluated digital breast tomosynthesis, magnetic resonance imaging, and ultrasound, and novel screening strategies have been recommended solely on the basis of improvements in breast cancer detection rates. Yet, the assumption that increases in tumor detection produce reductions in cancer mortality has not been validated, and tumor-detection endpoints may exacerbate the problem of overdiagnosis. Indeed, the detection of greater numbers of early stage breast cancers in the absence of a subsequent decline in rates of metastatic cancers and cancer-related mortality is the hallmark of overdiagnosis. There is now evidence to suggest that both ductal carcinoma in situ and invasive cancers are overdiagnosed as a consequence of screening. For each patient who is overdiagnosed with breast cancer, the adverse consequences include unnecessary anxiety, financial hardships, and a small risk of morbidity and mortality from unnecessary treatments. Moreover, the overtreatment of breast cancer, as a consequence of overdiagnosis, is costly and contributes to waste in health-care spending. In this article, we argue that there is a need to establish better endpoints in breast cancer screening trials, including quality of life and composite endpoints. Tumor-detection endpoints should be abandoned, because they may lead to the implementation of screening strategies that increase the risk of overdiagnosis.

scholarly journals Role of Detection Method in Predicting Breast Cancer Survival: Analysis of Randomized Screening Trials

2005 ◽  
Vol 97 (16) ◽  
pp. 1195-1203 ◽  
Author(s):  
Yu Shen ◽  
Ying Yang ◽  
Lurdes Y. T. Inoue ◽  
Mark F. Munsell ◽  
Anthony B. Miller ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Survival Analysis ◽  
Cancer Survival ◽  
Detection Method ◽  
Breast Cancer Survival ◽  
Screening Trials

Uptake of breast cancer prevention and screening trials

2010 ◽  
Vol 47 (12) ◽  
pp. 853-855 ◽  
Author(s):  
D. G. Evans ◽  
M. Harvie ◽  
N. Bundred ◽  
A. Howell
Keyword(s):  
Breast Cancer ◽  
Cancer Prevention ◽  
Breast Cancer Prevention ◽  
Cancer Prevention And Screening ◽  
Screening Trials

An Overview of the Swedish Randomised Mammography Trials: Total Mortality Pattern and the Representivity of the Study Cohorts

1996 ◽  
Vol 3 (2) ◽  
pp. 85-87 ◽  
Author(s):  
Lennarth Nyström ◽  
Lars-Gunnar Larsson ◽  
Stig Wall ◽  
Lars Erik Rutqvist ◽  
Ingvar Andersson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cause Of Death ◽  
Mammography Screening ◽  
Breast Cancer Mortality ◽  
Total Mortality ◽  
Control Group ◽  
Control Groups ◽  
Mortality Pattern ◽  
And Control ◽  
Screening Trials

Objectives –To analyse the cause of death pattern in the cohorts of women included in the Swedish randomised mammography screening trials by comparing the groups of invited and control women both with each other and with the general population of Swedish women. Setting –Since 1977 four randomised trials of mammography screening have been performed in Sweden: Malmö, Kopparberg and ÖOstergötland (the two county trial), Stockholm, and Gothenburg. Design –Overview of four randomised mammography screening trials. Results –The total numbers of deaths in the invited and control groups respectively were 15 695 and 11 887 corresponding to a relative risk (RR) of 1.00. There were no significant differences between the invited and control groups for cause-specific mortality, except for breast cancer. When the total mortality in the invited and the control groups was compared with that for Swedish women in general the standardised mortality ratio was close to 100. Conclusions –The cause of death pattern in the invited group was, except for breast cancer, very similar to that in the control group, showing that the groups were comparable. Similarly, the total mortality including breast cancer mortality in the control group was almost identical to that in Swedish women in general. The same was true, with the exception of breast cancer, for the invited group. These observations confirm that the trial cohorts are representative of Swedish women and indicate that the quantitative results from these trials may safely be generalised to the Swedish population.

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