Exploring the interactions between Hp infection and other risk factors of gastric cancer: a pooled analysis in the Stomach cancer Pooling ( StoP ) Project

2021 ◽  
Author(s):  
Giulia Collatuzzo ◽  
Claudio Pelucchi ◽  
Eva Negri ◽  
Lizbeth López‐Carrillo ◽  
Shoichiro Tsugane ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Stomach Cancer ◽  
Pooled Analysis

scholarly journals Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project

2020 ◽  
Vol 147 (11) ◽  
pp. 3090-3101 ◽  
Author(s):  
Ana Ferro ◽  
Ana Rute Costa ◽  
Samantha Morais ◽  
Paola Bertuccio ◽  
Matteo Rota ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Stomach Cancer ◽  
Fruits And Vegetables ◽  
Pooled Analysis ◽  
Gastric Cancer Risk ◽  
Fruits And Vegetables Intake

Physical activity and gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
J Stojanovic ◽  
R Pastorino ◽  
L Giraldi ◽  
C La Vecchia ◽  
E Negri ◽  
...  
Keyword(s):  
Physical Activity ◽  
Gastric Cancer ◽  
Stomach Cancer ◽  
Pooled Analysis

scholarly journals Leisure-time physical activity and gastric cancer risk: a pooled study within the Stomach cancer Pooling (StoP) Project

2020 ◽  
Author(s):  
Jovana Stojanovic ◽  
Luca Giraldi ◽  
Ken C Johnson ◽  
Jinfu Hu ◽  
Antonio Molina de la Torre ◽  
...  
Keyword(s):  
Physical Activity ◽  
Gastric Cancer ◽  
Stomach Cancer ◽  
Leisure Time ◽  
Protective Factor ◽  
Random Effect ◽  
Pooled Analysis ◽  
Case Control ◽  
Significant Heterogeneity ◽  
Case Control Studies

Abstract Background Physical activity (PA) has been recognized as a protective factor against several types of cancer, though robust evidence related to Gastric Cancer (GC) are lacking. This study aimed to establish whether leisure-time PA can prevent GC using data from a large pooled analysis of case-control studies within the Stomach cancer Pooling (StoP) Project.Methods Five case-control studies from StoP project collected data on PA, for a total of 2,415 cases and 9,722 controls. Subjects were classified into three leisure-time PA categories, either none/low, intermediate or high, based on study-specific tertiles. We used a two-stage approach. Firstly, we applied multivariable logistic regression models to obtain study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Afterwards, we used a random-effect models for estimating pooled effect estimates. Heterogeneity across studies was assessed using Q and I 2 statistics. We performed stratified analyses according to demographic, lifestyle and clinical covariates.Results The pooled ORs for GC risk were 0.90 (95% CI: 0.72, 1.13) for intermediate, and 0.72 (95% CI: 0.57, 0.91) for high levels of leisure-time PA. There was no evidence of significant heterogeneity in outcome estimates ( I 2 = 49.7%; p=0.094 for intermediate; I 2 = 42.9%, p=0.135 for high levels of exposure). GC risk estimates did not differ across strata of selected covariates.Conclusions Our study is the largest pooled analysis that provides insights about protective effects of high levels of recreational PA on GC risk. Although our results should be confirmed from large cohort studies, the implications have relevant public health significance.

Adult height and risk of gastric cancer: a pooled analysis within the stomach cancer pooling project

2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
L Giraldi ◽  
J Stojanovic ◽  
D Arzani ◽  
R Persiani ◽  
J Hu Harbin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stomach Cancer ◽  
Adult Height ◽  
Pooled Analysis

Adult height and risk of gastric cancer: a pooled analysis within the stomach cancer pooling project

2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
L Giraldi ◽  
J Stojanovic ◽  
D Arzani ◽  
R Persiani ◽  
J Hu Harbin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stomach Cancer ◽  
Adult Height ◽  
Pooled Analysis

Physical activity and gastric cancer: a pooled analysis within the Stomach cancer Pooling Project

2018 ◽  
Vol 28 (suppl_4) ◽  
Author(s):  
J Stojanovic ◽  
R Pastorino ◽  
L Giraldi ◽  
C La Vecchia ◽  
E Negri ◽  
...  
Keyword(s):  
Physical Activity ◽  
Gastric Cancer ◽  
Stomach Cancer ◽  
Pooled Analysis

scholarly journals Polyphenol Intake and Gastric Cancer Risk: Findings from the Stomach Cancer Pooling Project (StoP)

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3064
Author(s):  
Facundo Vitelli-Storelli ◽  
Marta Rossi ◽  
Claudio Pelucchi ◽  
Matteo Rota ◽  
Domenico Palli ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stomach Cancer ◽  
Smoking Habit ◽  
Random Effect ◽  
Pooled Analysis ◽  
Favorable Effect ◽  
Total Phenolic ◽  
Individual Participant ◽  
Hydroxybenzoic Acids ◽  
Polyphenol Intake

Phenolic compounds may exert a favorable effect on the risk of several cancer types, including gastric cancer (GC). However, selected polyphenol classes have not been adequately investigated in relation to GC. The aim of this study is to evaluate the association between the intake of polyphenols in relation to GC risk. We used data from the Stomach cancer Pooling (StoP) Project, including 10 studies from six countries (3471 GC cases and 8344 controls). We carried out an individual participant data pooled analysis using a two-stage approach. The summary odds ratios (ORs) of GC for each compound, and the corresponding 95% confidence intervals (95% CI), were computed by pooling study specific ORs obtained through multivariate logistic regression, using random effect models. Inverse associations with GC emerged for total polyphenols (OR = 0.67, 95% CI = 0.54–0.81, for the highest versus lowest quartile of intake), total flavonoids (OR = 0.73, 95% CI = 0.55–0.90), anthocyanidins (OR = 0.74, 95% CI = 0.56–0.92), flavanols (OR = 0.77, 95% CI = 0.66–0.88), flavanones (OR = 0.57, 95%CI = 0.44–0.69), total phenolic acids (OR = 0.75, 95%CI = 0.55–0.94), and hydroxybenzoic acids (OR = 0.73, 95%CI = 0.57–0.89). Results were consistent across strata of age, sex, social class, and smoking habit. Suggestive inverse associations were also found for flavonols (OR = 0.76, 95%CI = 0.51–1.01) and hydroxycinnamic acids (OR = 0.82, 95%CI = 0.58–1.06). Further investigations from longitudinal data are needed to confirm this association.

BIOPSY OF THE SIGNALING LYMPH NODES IN GASTRIC CANCER - CURRENT STATUS OF THE PROBLEM AND PROSPECTS

2018 ◽  
Vol 64 (3) ◽  
pp. 335-344
Author(s):  
Aleksey Karachun ◽  
Yuriy Pelipas ◽  
Oleg Tkachenko ◽  
D. Asadchaya
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Stomach Cancer ◽  
Current Status ◽  
Regional Lymph Nodes ◽  
Systematic Analysis ◽  
Tumor Spread ◽  
Special Value

The concept of biopsy of sentinel lymph node as the first lymph node in the pathway of lymphogenous tumor spread has been actively discussed over the past decades and has already taken its rightful place in breast and melanoma surgery. The goal of this method is to exclude vain lymphadenectomy in patients without solid tumor metastases in regional lymph nodes. In the era of minimally invasive and organ-saving operations interventions it seems obvious an idea to introduce a biopsy of sentinel lymph node in surgery of early gastric cancer. Meanwhile the complexity of lymphatic system of the stomach and the presence of so-called skip metastases are factors limiting the introduction of a biopsy of sentinel lymph node in stomach cancer. This article presents a systematic analysis of biopsy technology of signaling lymph node as well as its safety and oncological adequacy. Based on literature data it seems to us that the special value of biopsy of sentinel lymph nodes in the future will be in the selection of personalized surgical tactics for stomach cancer.

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