Dietary inflammatory potential, oxidative balance score, and risk of breast cancer: findings from the Sister Study

2021 ◽  
Author(s):  
Yong‐Moon Mark Park ◽  
Nitin Shivappa ◽  
Joshua Petimar ◽  
M. Elizabeth Hodgson ◽  
Hazel B. Nichols ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Balance ◽  
Oxidative Balance Score

scholarly journals Dietary Oxidative Balance Score and Disease Characteristics in Patients with Rheumatoid Arthritis (P01-036-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Melissa Choi ◽  
Christina Son ◽  
Mary Kiely ◽  
Yusuf Yazici ◽  
Kathleen Woolf
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Physical Function ◽  
Morning Stiffness ◽  
Disease Process ◽  
Alcohol Exposure ◽  
Oxidative Balance ◽  
Organ Systems ◽  
Oxidative Balance Score ◽  
The Relationship

Abstract Objectives Rheumatoid arthritis (RA) is an autoimmune disease accompanied by pain, joint stiffness, and swelling, impacting quality of life. RA is also an articular disorder affecting multiple organ systems. Oxidative stress and antioxidants may play a role in the disease process. The oxidative balance score (OBS) is a composite estimate of exogenous dietary, lifestyle, and medication factors associated with antioxidant and pro-oxidant properties. This study examined the relationship between OBS and disease activity in RA. Methods 84 adults with RA (mean age: 52.9 ± 14.4 years; RA disease duration: 13.5 ± 9.2 years) were recruited from the NYU Langone Orthopedic Center. Disease activity was assessed via C-reactive protein, erythrocyte sedimentation rate, and the Multi-Dimensional Health Assessment Questionnaire, which includes self-reported measures of physical function, pain, & global status (summed into the RAPID3 score), fatigue, painful joint count, and duration of morning stiffness. Higher scores indicate greater disease activity. Participants completed 7-day food records, which were analyzed using Nutrition Data System for Research. OBS was calculated by analyzing 13 a priori-defined pro-oxidant (polyunsaturated fatty acid and iron) and antioxidant (selenium, vitamin C, vitamin E, α-carotene, β-carotene, lutein + zeaxanthin, lycopene, cryptoxanthine; use of aspirin and non-steroidal anti-inflammatory drugs, and alcohol) exposure factors. A higher OBS scored indicated more antioxidant and less pro-oxidant exposure. Partial correlations examined the relationship between OBS and disease activity, while controlling for age, using IBM SPSS Statistics. Results There was a negative association between OBS and duration of morning stiffness (r = −0.290, P = 0.010); as OBS increased, duration of morning stiffness decreased. Although not statistically significant, there was a negative trend between OBS and physical function (r = −0.180, P = 0.113), pain (r = −0.194, P = 0.086), and RAPID3 (r = −0.195, P = 0.103); as OBS increased, physical function, pain, and disease activity improved. No statistically significant relationships were seen between OBS and the other measures of disease activity. Conclusions In this study, a higher OBS score was associated with lower disease activity. More research is needed to understand the relationship of these lifestyle exposures to RA. Funding Sources NYU Steinhardt Research Challenge Grant.

scholarly journals Oxidative balance score as predictor of all-cause, cancer, and noncancer mortality in a biracial US cohort

2015 ◽  
Vol 25 (4) ◽  
pp. 256-262.e1 ◽  
Author(s):  
So Yeon Kong ◽  
Michael Goodman ◽  
Suzanne Judd ◽  
Roberd M. Bostick ◽  
W. Dana Flanders ◽  
...  
Keyword(s):  
Oxidative Balance ◽  
Oxidative Balance Score

scholarly journals Oxidative balance score and risk for incident prostate cancer in a prospective U.S. cohort study

2014 ◽  
Vol 24 (6) ◽  
pp. 475-478.e4 ◽  
Author(s):  
Sindhu Lakkur ◽  
Michael Goodman ◽  
Roberd M. Bostick ◽  
Jessica Citronberg ◽  
William McClellan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Oxidative Balance ◽  
Oxidative Balance Score

Oxidative balance score and risk of osteoporosis among postmenopausal Iranian women

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zahra Shahriarpour ◽  
Bita Nasrabadi ◽  
Sudiyeh Hejri-Zarifi ◽  
Seyedeh-Elaheh Shariati-Bafghi ◽  
Mahboobe Yousefian-Sanny ◽  
...  
Keyword(s):  
Iranian Women ◽  
Oxidative Balance ◽  
Oxidative Balance Score

scholarly journals Oxidative stress, oxidative balance score, and hypertension among a racially diverse population

2015 ◽  
Vol 9 (8) ◽  
pp. 592-599 ◽  
Author(s):  
Francis B. Annor ◽  
Michael Goodman ◽  
Ike S. Okosun ◽  
Douglas W. Wilmot ◽  
Dora Il'yasova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diverse Population ◽  
Racially Diverse ◽  
Oxidative Balance ◽  
Oxidative Balance Score ◽  
Stress Oxidative

scholarly journals Oxidative Balance Score, Colorectal Adenoma, and Markers of Oxidative Stress and Inflammation

2014 ◽  
Vol 23 (3) ◽  
pp. 545-554 ◽  
Author(s):  
So Yeon J. Kong ◽  
Roberd M. Bostick ◽  
W. Dana Flanders ◽  
William M. McClellan ◽  
Bharat Thyagarajan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Adenoma ◽  
Oxidative Balance ◽  
Markers Of Oxidative Stress ◽  
Oxidative Balance Score

Higher Oxidative Balance Score Is Associated with Better Glycemic Control among Iranian Adults with Type-2 Diabetes

2019 ◽  
pp. 1-9
Author(s):  
Mona Golmohammadi ◽  
Pravin Ayremlou ◽  
Rasoul Zarrin
Keyword(s):  
Type 2 Diabetes ◽  
Fatty Acid ◽  
Glycemic Control ◽  
Mean Difference ◽  
Analysis Of Covariance ◽  
Dietary Intakes ◽  
Oxidative Balance ◽  
Anti Oxidant ◽  
Oxidative Balance Score

Abstract. The oxidative balance score (OBS) is a measure of combined pro- and anti-oxidant exposure status, with a higher OBS representing a predominance of anti- over pro-oxidant exposures. We aimed to examine the association of OBS and glycemic control among Iranian adults with type-2 diabetes. This cross-sectional study was conducted among 476 adults with type-2 diabetes (mean age 56.2 y; 66.6% female). Fasting glycosylated hemoglobin (HbA1c) and serum glucose (FSG) levels were measured as markers of glycemic control. The OBS was calculated by combining information from a total of 18 a priori selected pro- and anti-oxidant components. These components were comprised of the following four categories: dietary anti-oxidants (i.e., dietary intakes of selenium, fiber, retinol, α-carotene, β-carotene, β-cryptoxanthin, lutein, lycopene, vitamin D, vitamin E, folate, and vitamin C); dietary pro-oxidants (i.e., dietary intakes of iron, saturated fatty acid, and poly-unsaturated fatty acid); non-dietary anti-oxidants (i.e., physical activity); and non-dietary pro-oxidants (i.e., smoking and obesity). After adjusting for several potential confounders in the analysis of covariance models, multivariable adjusted means of HbA1c and FSG of subjects in the highest tertile of OBS were significantly lower than those in the lowest tertile (for HbA1c: mean difference –0.73%; and for FSG: mean difference –10.2 mg/dL; both P < 0.050). The findings suggest that a higher OBS, indicating a predominance of anti- over pro-oxidant exposures, is associated with a better glycemic control among Iranian adults with type-2 diabetes. However, future prospective studies of adequate methodological quality are warranted to confirm these findings.

Oxidative Balance Score and the Risk of End-Stage Renal Disease and Cardiovascular Disease

2017 ◽  
Vol 45 (4) ◽  
pp. 338-345 ◽  
Author(s):  
Titilayo O. Ilori ◽  
Xiao Wang ◽  
Morong Huang ◽  
Orlando M. Gutierrez ◽  
K.M. Venkat Narayan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Cox Proportional Hazards ◽  
Oxidative Balance ◽  
Crude Model ◽  
Oxidative Balance Score ◽  
Stage Renal Disease ◽  
End Stage ◽  
Adjusted Model

Background: Oxidative balance score (OBS) is a composite measure of oxidative stress-related exposures. The aim of this study was to investigate the association between OBS, end-stage renal disease (ESRD), and cardiovascular disease (CVD). Methods: Using data from the Chronic Renal Insufficiency Cohort, we calculated the main exposure OBS by summing up 12 apriori-defined pro- and antioxidant factors obtained from the diet history questionnaire and lifestyle assessment. We divided OBS into quartiles (Q1-Q4), with Q1 (predominance of pro-oxidants) as the reference. We analyzed OBS quartiles as an ordinal variable. Crude and adjusted hazards ratios (HRs) and 95% CIs were estimated using Cox proportional hazards models for time to ESRD and CVD. Results: Compared to Q1, Q4 (high antioxidant) was associated with ESRD in the crude model (HR 1.35, 95% CI 1.08-1.69) and adjusting for age, sex, and race (HR 1.36, 95% CI 1.09-1.71) but not in the fully adjusted model (HR 1.12, 95% CI 0.84-1.51). HR of ESRD increased as the OBS quartiles increased in the crude model (ptrend < 0.05) but not in the fully adjusted model (ptrend = 0.30). Compared to Q1, Q4 was associated with CVD in the crude (HR 1.33, 95% CI 1.06-1.68) but not adjusted models. The HR of CVD increased with an increase in OBS quartiles in the crude model (ptrend < 0.05). Conclusion: The reverse association between OBS and progression to ESRD suggests that perhaps the effect of oxidative balance-related exposure is different in the setting of established chronic kidney disease.

scholarly journals Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: The breast cancer health disparities study

2013 ◽  
Vol 134 (3) ◽  
pp. 629-644 ◽  
Author(s):  
Martha L. Slattery ◽  
Esther M. John ◽  
Gabriela Torres-Mejia ◽  
Abbie Lundgreen ◽  
Juan Pablo Lewinger ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Health Disparities ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Health Disparities ◽  
Oxidative Balance
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