scholarly journals Circulating insulin‐like growth factor‐I , total and free testosterone concentrations and prostate cancer risk in 200 000 men in UK Biobank

2020 ◽  
Author(s):  
Eleanor L. Watts ◽  
Georgina K. Fensom ◽  
Karl Smith Byrne ◽  
Aurora Perez‐Cornago ◽  
Naomi E. Allen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Free Testosterone ◽  
Insulin Like Growth Factor ◽  
Uk Biobank ◽  
Factor I ◽  
Growth Factor I

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 ◽  
Vol 160 (1) ◽  
pp. 267-267 ◽  
Author(s):  
J.M. Chan ◽  
M.J. Stampfer ◽  
E. Giovannucci ◽  
P.H. Gann ◽  
J. Ma ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Prospective Study ◽  
Plasma Insulin ◽  
Prostate Cancer Risk ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
A Prospective Study

409: High Levels of Circulating Insulin-Like Growth Factor-I Increase Prostate Cancer Risk. A Prospective Study

2004 ◽  
Vol 171 (4S) ◽  
pp. 108-108
Author(s):  
Pär Stattin ◽  
Sabine Rinaldi ◽  
Carine Biessy ◽  
Ulf-Håkan Stenman ◽  
Göran Hallmans ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Prospective Study ◽  
Prostate Cancer Risk ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
A Prospective Study ◽  
Increase Prostate Cancer Risk

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk

1998 ◽  
pp. 267 ◽  
Author(s):  
J. M. Chan ◽  
M. J. Stampfer ◽  
E. Giovannucci ◽  
P. H. Gann ◽  
J. &NA; ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Plasma Insulin ◽  
Prostate Cancer Risk ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

High Levels of Circulating Insulin-Like Growth Factor-I Increase Prostate Cancer Risk: A Prospective Study in a Population-Based Nonscreened Cohort

2004 ◽  
Vol 22 (15) ◽  
pp. 3104-3112 ◽  
Author(s):  
Pär Stattin ◽  
Sabina Rinaldi ◽  
Carine Biessy ◽  
Ulf-Håkan Stenman ◽  
Göran Hallmans ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Population Based ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Bottom Quartile ◽  
Igf I ◽  
Igfbp 3

PurposeInsulin-like growth factor-I (IGF-I) stimulates proliferation and inhibits apoptosis in prostate cancer cells, and IGF-I has been associated with increased prostate cancer risk in some, but not all, epidemiologic studies.Subjects and MethodsWe extended our previous case-control study nested in the Northern Sweden Health and Disease Cohort, a population-based cohort from a region where little prostate specific antigen (PSA) screening is done. Levels of IGF-I and IGF binding protein-3 (IGFBP-3) were measured in prediagnostic blood samples from a total of 281 men who were subsequently diagnosed with prostate cancer after recruitment (median, 5 years after blood collection) and from 560 matched controls.ResultsLogistic regression analyses showed increases in prostate cancer risk with increasing plasma peptide levels, up to an odds ratio (OR) for top versus bottom quartile of IGF-I of 1.67 (95% CI, 1.02 to 2.71; Ptrend= .05), which was attenuated after adjustment for IGFBP-3 to an OR of 1.47 (95% CI, 0.81 to 2.64; Ptrend= .32). For men younger than 59 years at recruitment, OR for top versus bottom quartile of IGF-I was 4.12 (95% CI, 1.01 to 16.70; Ptrend= .002), which was significantly stronger than for men older than 59 years (Pinteraction= .006). For men with advanced cancer, OR for top versus bottom quartile of IGF-I was 2.87 (95% CI, 1.01 to 8.12; Ptrend= .10).ConclusionOur data add further support for IGF-I as an etiologic factor in prostate cancer and indicate that circulating IGF-I levels measured at a comparatively young age may be most strongly associated with prostate cancer risk.

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