Prevalence of comprehensive DNA damage repair gene germline mutations in Chinese prostate cancer patients

2020 ◽  
Vol 148 (3) ◽  
pp. 673-681
Author(s):  
Junlong Wu ◽  
Yu Wei ◽  
Jian Pan ◽  
Shengming Jin ◽  
Weijie Gu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Cancer Patients ◽  
Dna Damage Repair ◽  
Germline Mutations ◽  
Repair Gene ◽  
Damage Repair

Abstract B075: Defining germline mutations of DNA damage repair genes in African American prostate cancer patients

2020 ◽  
Author(s):  
Kevin Babcock ◽  
Xijun Zhang ◽  
Matthew Wilkerson ◽  
Clifton L. Dalgard ◽  
Shyh-Han Tan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
African American ◽  
Cancer Patients ◽  
Dna Damage Repair ◽  
Germline Mutations ◽  
Damage Repair ◽  
Repair Genes

DNA damage repair gene mutation testing and genetic counseling in men with/without prostate cancer: a systematic review

2020 ◽  
Author(s):  
Nigel Armstrong ◽  
Ruben GW Quek ◽  
Steve Ryder ◽  
Janine Ross ◽  
Titas Buksnys ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Systematic Review ◽  
At Risk ◽  
Dna Damage ◽  
Clinical Trials ◽  
Genetic Counseling ◽  
Mutation Screening ◽  
Dna Damage Repair ◽  
Mutation Testing ◽  
Damage Repair

Background: Ongoing clinical trials are investigating poly(ADP-ribose) polymerase (PARP) inhibitors to target the DNA damage repair (DDR) pathway in prostate cancer. DDR mutation screening will guide treatment strategy and assess eligibility for clinical trials. Materials & methods: This systematic review estimated the rate of DDR mutation testing or genetic counseling among men with or at risk of prostate cancer. Results: From 6856 records, one study fulfilled the inclusion criteria and described men undiagnosed with prostate cancer with a family history of BRCA1/2 mutation who received DDR mutation testing. Conclusion: With only one study included in this first systematic review of DDR mutation testing or genetic counseling in men with or at risk of prostate cancer, more research is warranted.

scholarly journals A DNA damage repair gene‐associated signature predicts responses of patients with advanced soft‐tissue sarcoma to treatment with trabectedin

2021 ◽  
Author(s):  
David S. Moura ◽  
Maria Peña‐Chilet ◽  
Juan Antonio Cordero Varela ◽  
Ramiro Alvarez‐Alegret ◽  
Carolina Agra‐Pujol ◽  
...  
Keyword(s):  
Dna Damage ◽  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Dna Damage Repair ◽  
Advanced Soft Tissue Sarcoma ◽  
Repair Gene ◽  
Damage Repair
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