Leukocyte telomere length, cancer incidence and all‐cause mortality among Chinese adults: Singapore Chinese Health Study

2020 ◽  
Vol 148 (2) ◽  
pp. 352-362
Author(s):  
Hamed Samavat ◽  
Hung N. Luu ◽  
Kenneth B. Beckman ◽  
Aizhen Jin ◽  
Renwei Wang ◽  
...  
Keyword(s):  
Telomere Length ◽  
Cancer Incidence ◽  
Health Study ◽  
Leukocyte Telomere Length ◽  
Chinese Adults ◽  
All Cause Mortality ◽  
Singapore Chinese

scholarly journals Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study

2018 ◽  
Vol 142 (11) ◽  
pp. 2234-2243 ◽  
Author(s):  
Jian-Min Yuan ◽  
Kenneth B. Beckman ◽  
Renwei Wang ◽  
Caroline Bull ◽  
Jennifer Adams-Haduch ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Telomere Length ◽  
Health Study ◽  
Leukocyte Telomere Length ◽  
Singapore Chinese

scholarly journals Impact of Combined Lifestyle Factors on All-Cause and Cause-Specific Mortality and Life Expectancy in Chinese: The Singapore Chinese Health Study

2019 ◽  
Vol 75 (11) ◽  
pp. 2193-2199
Author(s):  
Xiong-Fei Pan ◽  
Yanping Li ◽  
Oscar H Franco ◽  
Jian-Min Yuan ◽  
An Pan ◽  
...  
Keyword(s):  
Life Expectancy ◽  
Cancer Mortality ◽  
Healthy Lifestyle ◽  
Lifestyle Factors ◽  
Health Study ◽  
Chinese Adults ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Singapore Chinese ◽  
Cvd Mortality

Abstract Background To examine the impact of combined lifestyle factors on premature mortality and life expectancy in Chinese adults. Methods A total of 44,052 Chinese adults aged 45–74 years free of cardiovascular disease (CVD), cancer, and diabetes were followed from recruitment (1993–1998) to the end of 2016 in the Singapore Chinese Health Study. A composite score (0–5 scale) was calculated based on five baseline healthy lifestyle factors including healthy diet, nonsmoking status, light to moderate alcohol drinking, being physically active and optimal body mass index. Mortality cases were identified through linkage with the nationwide death registry. Results Adopting five healthy versus none was associated with a lower risk of all-cause and cause-specific mortality, and the hazard ratio (95% confidence interval [CI]) was 0.38 (0.29, 0.51) for all-cause mortality, 0.26 (0.13, 0.52) for CVD mortality, and 0.59 (0.37, 0.92) for cancer mortality. Nonadherence to 4–5 healthy lifestyle factors accounted for 34.9% (95% CI = 29.2, 40.2) in population attributable fraction for all-cause mortality, 35.1% (23.7, 44.9) for CVD mortality, and 18.0% (6.5, 28.0) for cancer mortality. Conversely, adherence to 4–5 healthy lifestyle factors versus none could achieve a gain of 8.1 years in women and 6.6 years in men for the life expectancy at 50 years. Conclusions A healthier lifestyle is associated with a substantially reduced risk of mortality and a longer life expectancy in the Chinese population. Our findings highlight the necessity of coordinated actions targeting combined lifestyle factors in reducing the overall burden of diseases and premature deaths.

scholarly journals Association Between Leukocyte Telomere Length and Colorectal Cancer Risk in the Singapore Chinese Health Study

2019 ◽  
Vol 10 (5) ◽  
pp. e00043 ◽  
Author(s):  
Hung N. Luu ◽  
Meiyuzhen Qi ◽  
Renwei Wang ◽  
Jennifer Adams-Haduch ◽  
Iva Miljkovic ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Telomere Length ◽  
Colorectal Cancer Risk ◽  
Health Study ◽  
Leukocyte Telomere Length ◽  
Singapore Chinese

Abstract MP26: Sleep duration and risk of stroke mortality among Chinese adults in Singapore: the Singapore Chinese Health Study

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
An Pan ◽  
Jian-Min Yuan ◽  
Woon-Puay Koh
Keyword(s):  
Sleep Duration ◽  
Reference Group ◽  
Total Mortality ◽  
Health Study ◽  
Stroke Mortality ◽  
Chinese Adults ◽  
Short Sleep Duration ◽  
Increased Risk ◽  
Long Sleep ◽  
Singapore Chinese

Introduction: Short or long sleep hours are associated with adverse health outcomes, including diabetes, hypertension, coronary heart disease (CHD) and total mortality. However, the prospective relation between sleep duration and stroke risk is less studied, particularly in Asians. Thus, we assessed the hypothesis that short (≤5 hours) and long (≥9 hours) sleep durations were related to increased risk of stroke mortality among Chinese adults residing in Singapore. Methods: The Singapore Chinese Health Study is a population-based cohort that recruited 63,257 Chinese adults aged 45-74 years during 1993 and 1998. Sleep duration was assessed at baseline and categorized to five groups: ≤5, 6, 7, 8 or ≥9 hours. Death information was identified via registry linkage up to December 31, 2011, with ICD-9 codes 430-438 for all stroke deaths, 430-432 for hemorrhagic, and 433-438 for ischaemic or non-specified stroke deaths. Cox proportional hazard models were used to calculate hazard ratios (HRs) with adjustment for socio-demographic, lifestyle and comorbidities. Results: We documented 1,381 total stroke deaths (322 hemorrhagic and 1,059 ischaemic or non-specified strokes) during 926,752 person-years of follow-up. Compared to the reference group of sleeping for 7 hours, the multivariate-adjusted HR (95% confidence interval) for total stroke mortality was 1.25 (1.05-1.50) for ≤5 hours, 1.01 (0.87-1.18) for 6 hours, 1.09 (0.95-1.26) for 8 hours, and 1.54 (1.28-1.85) for ≥9 hours. The increased risk was also observed for ischaemic or non-specified stroke deaths with short (1.37; 1.12-1.68) and long (1.68; 1.36-2.06) sleep durations, but not for hemorrhagic stroke deaths (0.92 [0.62-1.36] and 1.14 [0.76-1.72], respectively). We observed significant interaction with baseline hypertension (P-interaction=0.04): positive association was found for short (1.54; 1.16-2.03) and long (1.95; 1.48-2.57) sleep durations among individuals with baseline hypertension, but not among those without baseline hypertension (1.07 [0.85-1.36] and 1.27 [0.98-1.63], respectively). Furthermore, in participants without baseline CHD/stroke, short and long sleep durations were related to an increased risk (HR 1.30 [1.07-1.57] and 1.43 [1.16-1.76], respectively); while in CHD/stroke patients, only long sleep duration was associated with an increased risk (2.34; 1.53-3.57), but not the short sleep duration (0.96; 0.57-1.62). Conclusions: In this large cohort study of Chinese adults, both short and long sleep durations were significantly associated with increased risks of stroke mortality. The associations were significant and stronger in hypertensive participants, but not in those without hypertension. Further studies are needed to confirm the interaction with hypertension and explore the mechanisms linking sleep quantity and stroke mortality.

scholarly journals Correction to: Association among dispositional mindfulness, self-compassion, and leukocyte telomere length in Chinese adults

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Shian-Ling Keng ◽  
Onn Siong Yim ◽  
Poh San Lai ◽  
Soo Hong Chew ◽  
Richard P. Ebstein
Keyword(s):  
Telomere Length ◽  
Leukocyte Telomere Length ◽  
Dispositional Mindfulness ◽  
Chinese Adults ◽  
Self Compassion
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