scholarly journals Loss of efficacy of subsequent nonsurgical therapy after primary treatment failure in pediatric low‐grade glioma patients—Report from the German SIOP‐LGG 2004 cohort

2020 ◽  
Vol 147 (12) ◽  
pp. 3471-3489
Author(s):  
Daniela Kandels ◽  
Torsten Pietsch ◽  
Brigitte Bison ◽  
Monika Warmuth‐Metz ◽  
Ulrich‐Wilhelm Thomale ◽  
...  
Keyword(s):  
Treatment Failure ◽  
Primary Treatment ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Nonsurgical Therapy

scholarly journals Management and outcome of focal low-grade brainstem tumors in pediatric patients: the St. Jude experience

2013 ◽  
Vol 11 (3) ◽  
pp. 274-281 ◽  
Author(s):  
Paul Klimo ◽  
Atmaram S. Pai Panandiker ◽  
Clinton J. Thompson ◽  
Frederick A. Boop ◽  
Ibrahim Qaddoumi ◽  
...  
Keyword(s):  
Overall Survival ◽  
Treatment Failure ◽  
Disease Progression ◽  
Pediatric Patients ◽  
Univariate Analysis ◽  
Primary Treatment ◽  
Symptom Duration ◽  
Low Grade ◽  
Brainstem Tumors

Object Whereas diffuse intrinsic pontine gliomas generally have a short symptom duration and more cranial nerve involvement, focal brainstem gliomas are commonly low grade, with fewer cranial neuropathies. Although these phenotypic distinctions are not absolute predictors of outcome, they do demonstrate correlation in most cases. Because there is a limited literature on focal brainstem gliomas in pediatric patients, the objective of this paper was to report the management and outcome of these tumors. Methods The authors reviewed the records of all children diagnosed with radiographically confirmed low-grade focal brainstem gliomas from 1986 to 2010. Each patient underwent biopsy or resection for tissue diagnosis. Event-free survival (EFS) and overall survival were evaluated. Univariate analysis was conducted to identify demographic and treatment variables that may affect EFS. Results Fifty-two patients (20 girls, 32 boys) with follow-up data were identified. Median follow-up was 10.0 years, and the median age at diagnosis was 6.5 years (range 1–17 years). The tumor locations were midbrain (n = 22, 42%), pons (n = 15, 29%), and medulla (n = 15, 29%). Surgical extirpation was the primary treatment in 25 patients (48%). The 5- and 10-year EFS and overall survival were 59%/98% and 52%/90%, respectively. An event or treatment failure occurred in 24 patients (46%), including 5 deaths. Median time to treatment failure was 3.4 years. Disease progression in the other 19 patients transpired within 25.1 months of diagnosis. Thirteen of these patients received radiation, including 11 within 2 months of primary treatment failure. Although children with intrinsic tumors had slightly better EFS at 5 years compared with those with exophytic tumors (p = 0.054), this difference was not significant at 10 years (p = 0.147). No other variables were predictive of EFS. Conclusions Surgery suffices in many children with low-grade focal brainstem gliomas. Radiation treatment is often reserved for disease progression but offers comparable disease control following biopsy. In the authors' experience, combining an assessment of clinical course, imaging, and tumor biopsy yields a reasonable model for managing children with focal brainstem tumors.

Development of a novel assay suitable for pre-clinical testing of MAPK inhibitors in low-grade glioma

2017 ◽  
Author(s):  
D Usta ◽  
F Selt ◽  
J Hohloch ◽  
S Pusch ◽  
SM Pfister ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Low Grade ◽  
Clinical Testing ◽  
Mapk Inhibitors

scholarly journals Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib

2021 ◽  
Vol 22 (3) ◽  
pp. 184-195
Author(s):  
Lily Deland ◽  
Simon Keane ◽  
Thomas Olsson Bontell ◽  
Helene Sjögren ◽  
Henrik Fagman ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Targeted Treatment ◽  
Low Grade

scholarly journals Automatic segmentation of low-grade glioma in MRI image based on UNet++ model

2020 ◽  
Vol 1693 ◽  
pp. 012135
Author(s):  
Dan Xu ◽  
Xidong Zhou ◽  
Xuefen Niu ◽  
Junwei Wang
Keyword(s):  
Automatic Segmentation ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Mri Image

scholarly journals Glioma with Leptomeningeal Spread Mimics Chronic Meningoencephalitis in a Young Adult

2021 ◽  
pp. 179-183
Author(s):  
Ann-Kristin Becker ◽  
Marta Leonora Frank ◽  
Michael Friese ◽  
Joachim Röther
Keyword(s):  
Brain Tumor ◽  
Back Pain ◽  
Young Adult ◽  
Lower Back Pain ◽  
Low Grade Glioma ◽  
Low Grade ◽  
Who Grade ◽  
Leptomeningeal Spread ◽  
Lower Back ◽  
Uncommon Case

The most malignant type of intrinsic brain tumor is glioblastoma (WHO grade IV). Primary leptomeningeal spread is rare and leads to a variety of differential considerations, as there is no typical clinical or imaging pattern. Here we present a rare and uncommon case of a primary leptomeningeal glioblastoma in combination with a low-grade glioma in a 21-year-old male, initially presenting with only headache and lower back pain. The presented case illustrates the challenging differential considerations and the severe course of leptomeningeal glioblastomas.

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