scholarly journals Germline variant burden in multidrug resistance transporters is a therapy‐specific predictor of survival in breast cancer patients

2020 ◽  
Vol 146 (9) ◽  
pp. 2475-2487 ◽  
Author(s):  
Qingyang Xiao ◽  
Yitian Zhou ◽  
Stefan Winter ◽  
Florian Büttner ◽  
Elke Schaeffeler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Germline Variant ◽  
Multidrug Resistance Transporters

Fractional retention of 99mTc-sestamibi for the phenotypic assessment of multidrug resistance in untreated breast cancer patients

The Breast ◽  
1997 ◽  
Vol 6 (5) ◽  
pp. 326
Author(s):  
R. Thomas ◽  
A. Ciarmiello ◽  
S. Del Vecchio ◽  
G. Botti ◽  
G. Cortino ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
99Mtc Sestamibi

scholarly journals MRP1 but Not MDR1 Is Associated with Response to Neoadjuvant Chemotherapy in Breast Cancer Patients

2013 ◽  
Vol 34 (6) ◽  
pp. 387-393 ◽  
Author(s):  
Mohsen Taheri ◽  
Frouzandeh Mahjoubi
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Histological Grade ◽  
Chemotherapeutic Agents ◽  
Response To Treatment ◽  
Breast Cancer Patients ◽  
Response To Chemotherapy ◽  
Mrp1 Expression

A major problem in the treatment of breast cancer is the development of resistance to chemotherapeutic agents. Although the role of multidrug resistance 1 (MDR1) and multidrug resistance associated protein 1 (MRP1) in inducing drug resistance in many cancers has been widely investigated the clinical significance of expression of these genes in breast cancer remains unclear and the data is still controversial. We investigated the expression of MDR1 and MRP1 in breast cancer patients as well as the possible correlation between MDR1 and MRP1 and clinical response to chemotherapy. In the present study, MDR1 and MRP1 gene expression were investigated by real time reverse transcription polymerase chain reaction (RT-PCR) assay in 54 breast cancer tumors and in corresponding adjacent normal tissues before neoadjuvant chemotherapy. The expression level of MDR1 and MRP1 were significantly higher in breast tumors than normal breast tissues. Although a significant relationship was found between the MRP1 expression and response to treatment no association was observed between MDR1 expression and response to treatment. MDR1 and MRP1 expression levels have been shown to be independent of tumor size, histological grade and the status of progesterone or estrogen receptor.

scholarly journals Multidrug Resistance Mediated by MRP1 Gene Overexpression in Breast Cancer Patients

2009 ◽  
Vol 27 (2) ◽  
pp. 201-205 ◽  
Author(s):  
Ogan Demir Abaan ◽  
Pelin Kaya Mutlu ◽  
Yusuf Baran ◽  
Can Atalay ◽  
Ufuk Gunduz
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Cancer Patients ◽  
Gene Overexpression ◽  
Breast Cancer Patients
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