scholarly journals Combined tumor plus nontumor interim FDG‐PET parameters are prognostic for response to chemoradiation in squamous cell esophageal cancer

2020 ◽  
Vol 147 (5) ◽  
pp. 1427-1436 ◽  
Author(s):  
Sebastian Zschaeck ◽  
Yimin Li ◽  
Rebecca Bütof ◽  
Chen Lili ◽  
Wu Hua ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Squamous Cell ◽  
Fdg Pet ◽  
Combined Tumor ◽  
Squamous Cell Esophageal Cancer

scholarly journals 18F-FDG PET/CT Parameters for Predicting Prognosis in Esophageal Cancer Patients Treated With Concurrent Chemoradiotherapy

2021 ◽  
Vol 20 ◽  
pp. 153303382110246
Author(s):  
Seokmo Lee ◽  
Yunseon Choi ◽  
Geumju Park ◽  
Sunmi Jo ◽  
Sun Seong Lee ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Patients ◽  
Fdg Pet ◽  
Concurrent Chemoradiotherapy ◽  
Curative Intent ◽  
Squamous Cell Esophageal Cancer ◽  
Pet Ct ◽  
Significant Difference ◽  
Fdg Pet Ct

Background and Aims: This study evaluated the prognostic value of 18F-fluorodeoxyglucose positron emission tomography with integrated computed tomography (18F-FDG PET/CT) performed before and after concurrent chemoradiotherapy (CCRT) in esophageal cancer. Methods: We analyzed the prognosis of 50 non-metastatic squamous cell esophageal cancer (T1-4N0-2) patients who underwent CCRT with curative intent at Inje University Busan Paik Hospital and Haeundae Paik Hospital from 2009 to 2019. Median total radiation dose was 54 Gy (range 34-66 Gy). Our aim was to investigate the relationship between PET/CT values and prognosis. The primary end point was progression-free survival (PFS). Results: The median follow-up period was 9.9 months (range 1.7-85.7). Median baseline maximum standard uptake value (SUVmax) was 14.2 (range 3.2-27.7). After treatment, 29 patients (58%) showed disease progression. The 3-year PFS and overall survival (OS) were 24.2% and 54.5%, respectively. PFS was significantly lower ( P = 0.015) when SUVmax of initial PET/CT exceeded 10 (n = 22). However, OS did not reach a significant difference based on maximum SUV ( P = 0.282). Small metabolic tumor volume (≤14.1) was related with good PFS ( P = 0.002) and OS ( P = 0.001). Small total lesion of glycolysis (≤107.3) also had a significant good prognostic effect on PFS ( P = 0.009) and OS ( P = 0.025). In a subgroup analysis of 18 patients with follow-up PET/CT, the patients with SUV max ≤3.5 in follow-up PET/CT showed longer PFS ( P = 0.028) than those with a maximum SUV >3.5. Conclusion: Maximum SUV of PET/CT is useful in predicting prognosis of esophageal cancer patients treated with CCRT. Efforts to find more effective treatments for patients at high risk of progression are still warranted.

Managing Squamous Cell Esophageal Cancer

2019 ◽  
Vol 99 (3) ◽  
pp. 529-541 ◽  
Author(s):  
Rishi Batra ◽  
Gautam K. Malhotra ◽  
Shailender Singh ◽  
Chandrakanth Are
Keyword(s):  
Esophageal Cancer ◽  
Squamous Cell ◽  
Squamous Cell Esophageal Cancer

Does Sex Affect Survival of Patients With Squamous Cell Esophageal Cancer?

2013 ◽  
Vol 31 (6) ◽  
pp. 815-816 ◽  
Author(s):  
Jie Zhang ◽  
David Garfield ◽  
Yizhou Jiang ◽  
Shengfei Wang ◽  
Sufeng Chen ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Squamous Cell ◽  
Squamous Cell Esophageal Cancer
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