scholarly journals Incidence of second primary malignancy after breast cancer and related risk factors—Is breast‐conserving surgery safe? A nested case–control study

2019 ◽  
Vol 146 (2) ◽  
pp. 352-362 ◽  
Author(s):  
Zhuyue Li ◽  
Kang Wang ◽  
Yang Shi ◽  
Xuemei Zhang ◽  
Jin Wen
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Breast Conserving Surgery ◽  
Case Control ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Related Risk ◽  
Nested Case Control ◽  
Control Study

scholarly journals Incidence, risk and survival outcomes of second primary malignancy among renal cell carcinoma survivors: A nested case-control study

2020 ◽  
Author(s):  
Zhixian Wang ◽  
Jing Wang ◽  
Yunpeng Zhu ◽  
Xing Li ◽  
Xiaoyong Zeng
Keyword(s):  
Renal Cell Carcinoma ◽  
Overall Survival ◽  
Case Control Study ◽  
Case Control ◽  
Survival Outcomes ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Nested Case Control ◽  
Control Study

Abstract Background: Second primary malignancy (SPM) challenges survival and surveillance protocols among renal cell carcinoma (RCC) survivors. The incidence, temporal patterns, survival outcomes, and risk factors of SPM after T1-4N0-1M0 RCC diagnosis need to be investigated. Method: A nested case-control study that was designed using the Surveillance, Epidemiology, and End Results database from 2004-15; A cohort of 6204 SPM were matched with a control group of 37224 non-SPM. Results: SPM shortens the overall survival (hazard ratio [HR], 1.34; 95% confidence interval [CI]: 1.28-1.42, P< 0.001). The median time interval to SPM was 54.5 months. The adjusted standardized incidence ratio (SIR) of SPM increases by survival time (SIR12~35-month: 12.04; SIR36~59-month: 12.67; SIR60~19-month: 16.08; SIR120+-years: 25.01, all P< 0.001), and decreased with age (SIR18~44-years: 86.68; SIR45~59-years: 26.95; SIR60~74-years: 12.43; SIR75+-years: 10.66, all P< 0.001). The second primary RCC onset, especially contralateral kidney, has the highest SIR (SIR: 54.6; 95%CI: 51.0~58.4) among all sites of SPM. Prostate cancer (29.8%) in male and breast cancer (23.5%) in female were the most common SPM site. Older age, black race, male gender, higher family income statues, papillary RCC, and lower TNM stage significantly increases the risk of SPMs diagnosis. A longer time to SPM interval positively associated with a higher tumor stage of a SPM onset (P trend <0.001). The overall survival since the SPM diagnosis was associated with SPM’s stages, site, and surgical treatment, but not associated with time-to-SPM. Conclusion: Collectively, our study described the epidemiological characteristics of SPM among RCC survivors and identified the independent predictors of the SPM onset and its survival outcomes, which provides the clinicians for patients consulting and long-term individual-, tailored site-, and time-specific surveillance to improve survival outcomes.

scholarly journals Standardized Incidence Rate, Risk and Survival Outcomes of Second Primary Malignancy Among Renal Cell Carcinoma Survivors: A Nested Case-Control Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Zhixian Wang ◽  
Yisheng Yin ◽  
Jing Wang ◽  
Yunpeng Zhu ◽  
Xing Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Case Control ◽  
Survival Outcomes ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Nested Case Control ◽  
Control Study

PurposeSecond primary malignancy (SPM) is challenging for treatment and long-term survival. We sought to investigate the standardized incidence rate (SIR), risk factors, and survival outcomes for SPM after renal cell carcinoma (RCC) treatment.MethodA nested case-control study was designed, we identified all T1-4N0-1M0 RCC patients diagnosed between 2004 and 2015 in the Surveillance, Epidemiology, and End Results database and followed them for SPM diagnosis for up to 13 years. Patients with SPM diagnosis ≥6 months after treatment of primary T1-4N0-1M0 RCC were identified as the case cohort and SPM-free patients were the control cohort. SIRs and the excess risk were calculated. A competing risks and Cox model were used to evaluate the risk factors of SPM and overall survival (OS).ResultsA cohort of 6,204 RCC patients with SPM were matched with a control group of 31,020 RCC patients without SPM. The median time-to-SPM interval was 54.5 months in RCC patients with SPM diagnosis. Besides, an SPM of T3/4 or/and M1 stage diagnosis was positively associated with a longer time-to-SPM interval. SIR of SPM increased by follow-up time and decreased with age at diagnosis (Pfor all &lt;0.001). SPM in the kidney had the highest SIR (54.6, P &lt;0.001) among all SPMs. Prostate cancer (29.8%) in males and breast cancer (23.5%) in females were the most common SPM. Older age, black ethnicity, male sex, higher family income, papillary RCC, and lower TNM stage were significant risk factors for SPM diagnosis. The proportion of deaths from SPM exceeds that of deaths from RCC 3 years after the first RCC treatment. Patients with SPM and early time-to-SPM interval shortens the OS compared with SPM-free patients. The 5-year OS was 85.9% and 58.9% from the first RCC and the SPM diagnosis, respectively. Besides, patients with low-grade/early-stage SPM could benefit from aggressive surgical treatment for solid tumors.ConclusionsCollectively, our study described the epidemiological characteristics of SPM among RCC survivors and identified the independent predictors of the SPM diagnosis and its survival outcomes. This study highlights the importance of patient education and follow-up after the surgery for RCC.

scholarly journals Risk of Second Primary Malignancy in Breast Cancer Survivors: A Nested Population-Based Case-Control Study

2015 ◽  
Vol 18 (4) ◽  
pp. 378 ◽  
Author(s):  
Raffaella Marcheselli ◽  
Luigi Marcheselli ◽  
Laura Cortesi ◽  
Alessia Bari ◽  
Claudia Cirilli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Second Primary ◽  
Second Primary Malignancy ◽  
Primary Malignancy ◽  
Control Study

scholarly journals Circulating carotenoids and breast cancer among high-risk individuals

2020 ◽  
Author(s):  
Cheng Peng ◽  
Chi Gao ◽  
Donghao Lu ◽  
Bernard A Rosner ◽  
Oana Zeleznik ◽  
...  
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Genetic Risk ◽  
Case Control Study ◽  
Case Control ◽  
Polygenic Risk Score ◽  
Nested Case Control ◽  
Control Study

ABSTRACT Background Carotenoids represent 1 of few modifiable factors to reduce breast cancer risk. Elucidation of interactions between circulating carotenoids and genetic predispositions or mammographic density (MD) may help inform more effective primary preventive strategies in high-risk populations. Objectives We tested whether women at high risk for breast cancer due to genetic predispositions or high MD would experience meaningful and greater risk reduction from higher circulating levels of carotenoids in a nested case-control study in the Nurses’ Health Studies (NHS and NHSII). Methods This study included 1919 cases and 1695 controls in a nested case-control study in the NHS and NHSII. We assessed both multiplicative and additive interactions. RR reductions and 95% CIs were calculated using unconditional logistic regressions, adjusting for matching factors and breast cancer risk factors. Absolute risk reductions (ARR) were calculated based on Surveillance, Epidemiology, and End Results incidence rates. Results We showed that compared with women at low genetic risk or low MD, those with higher genetic risk scores or high MD had greater ARRs for breast cancer as circulating carotenoid levels increase (additive P-interaction = 0.05). Among women with a high polygenic risk score, those in the highest quartile of circulating carotenoids had a significant ARR (28.6%; 95% CI, 14.8–42.1%) compared to those in the lowest quartile of carotenoids. For women with a high percentage MD (≥50%), circulating carotenoids were associated with a 37.1% ARR (95% CI, 21.7–52.1%) when comparing the highest to the lowest quartiles of circulating carotenoids. Conclusions The inverse associations between circulating carotenoids and breast cancer risk appeared to be more pronounced in high-risk women, as defined by germline genetic makeup or MD.

scholarly journals Circulating levels of 25-hydroxyvitamin D and risk of breast cancer: a nested case-control study

2013 ◽  
Vol 15 (1) ◽  
Author(s):  
Stephanie Scarmo ◽  
Yelena Afanasyeva ◽  
Per Lenner ◽  
Karen L Koenig ◽  
Ronald L Horst ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Case Control Study ◽  
Case Control ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Nested Case Control ◽  
Circulating Levels ◽  
Control Study
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