scholarly journals The histone chaperone complex FACT promotes proliferative switch of G 0 cancer cells

2018 ◽  
Vol 145 (1) ◽  
pp. 164-178 ◽  
Author(s):  
Ling Bi ◽  
Chanlu Xie ◽  
Mu Yao ◽  
Su Su Thae Hnit ◽  
Soma Vignarajan ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Histone Chaperone ◽  
Chaperone Complex

scholarly journals A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A

Genetics ◽  
2018 ◽  
Vol 210 (1) ◽  
pp. 203-218 ◽  
Author(s):  
Sultan Ciftci-Yilmaz ◽  
Wei-Chun Au ◽  
Prashant K. Mishra ◽  
Jessica R. Eisenstatt ◽  
Joy Chang ◽  
...  
Keyword(s):  
Budding Yeast ◽  
Histone Chaperone ◽  
Genome Wide ◽  
A Genome ◽  
Chaperone Complex

scholarly journals FKBP51 Promotes Assembly of the Hsp90 Chaperone Complex and Regulates Androgen Receptor Signaling in Prostate Cancer Cells

2010 ◽  
Vol 30 (5) ◽  
pp. 1243-1253 ◽  
Author(s):  
Li Ni ◽  
Chun-Song Yang ◽  
Daniel Gioeli ◽  
Henry Frierson ◽  
David O. Toft ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
Feedback Loop ◽  
Critical Role ◽  
Prostate Cancer Cells ◽  
Androgen Receptor Signaling ◽  
Hsp90 Chaperone ◽  
Chaperone Complex ◽  
Androgen Binding

ABSTRACT Prostate cancer progression to the androgen-independent (AI) state involves acquisition of pathways that allow tumor growth under low-androgen conditions. We hypothesized that expression of molecular chaperones that modulate androgen binding to AR might be altered in prostate cancer and contribute to progression to the AI state. Here, we report that the Hsp90 cochaperone FKBP51 is upregulated in LAPC-4 AI tumors grown in castrated mice and describe a molecular mechanism by which FKBP51 regulates AR activity. Using recombinant proteins, we show that FKBP51 stimulates recruitment of the cochaperone p23 to the ATP-bound form of Hsp90, forming an FKBP51-Hsp90-p23 superchaperone complex. In cells, FKBP51 expression promotes superchaperone complex association with AR and increases the number of AR molecules that undergo androgen binding. FKBP51 stimulates androgen-dependent transcription and cell growth, and FKBP51 is part of a positive feedback loop that is regulated by AR and androgen. Finally, depleting FKBP51 levels by short hairpin RNA reduces the transcript levels of genes regulated by AR and androgen. Because the superchaperone complex plays a critical role in determining the ligand-binding competence and transcription function of AR, it provides an attractive target for inhibiting AR activity in prostate cancer cells.

Electromagnetic fields at mobile phone frequency induce apoptosis and inactivation of the multi-chaperone complex in human epidermoid cancer cells

2005 ◽  
Vol 204 (2) ◽  
pp. 539-548 ◽  
Author(s):  
Michele Caraglia ◽  
Monica Marra ◽  
Fabrizio Mancinelli ◽  
Guglielmo D'ambrosio ◽  
Rita Massa ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Cancer Cells ◽  
Electromagnetic Fields ◽  
Chaperone Complex

scholarly journals Mechanism of FACT removal from transcribed genes by anticancer drugs curaxins

2018 ◽  
Vol 4 (11) ◽  
pp. eaav2131 ◽  
Author(s):  
Han-Wen Chang ◽  
Maria E. Valieva ◽  
Alfiya Safina ◽  
Răzvan V. Chereji ◽  
Jianmin Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Anticancer Drugs ◽  
Protein Complex ◽  
Tight Binding ◽  
Histone Chaperone ◽  
Chaperone Activity ◽  
Multifunctional Protein ◽  
Transcription In Vitro ◽  
Facilitates Chromatin Transcription

Human FACT (facilitates chromatin transcription) is a multifunctional protein complex that has histone chaperone activity and facilitates nucleosome survival and transcription through chromatin. Anticancer drugs curaxins induce FACT trapping on chromatin of cancer cells (c-trapping), but the mechanism of c-trapping is not fully understood. Here, we show that in cancer cells, FACT is highly enriched within the bodies of actively transcribed genes. Curaxin-dependent c-trapping results in redistribution of FACT from the transcribed chromatin regions to other genomic loci. Using a combination of biochemical and biophysical approaches, we have demonstrated that FACT is bound to and unfolds nucleosomes in the presence of curaxins. This tight binding to the nucleosome results in inhibition of FACT-dependent transcription in vitro in the presence of both curaxins and competitor chromatin, suggesting a mechanism of FACT trapping on bulk nucleosomes (n-trapping).

scholarly journals Chemotherapy regimen GOLF induces apoptosis in colon cancer cells through multi-chaperone complex inactivation and increased raf-1 ubiquitin-dependent degradation

2005 ◽  
Vol 4 (10) ◽  
pp. 1159-1167 ◽  
Author(s):  
Michele Caraglia ◽  
Monica Marra ◽  
Alfredo Budillon ◽  
Giuseppina Meo ◽  
Filippo Ricciardiello ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Chemotherapy Regimen ◽  
Colon Cancer Cells ◽  
Chaperone Complex

Abstract 348: Targeting histone chaperone FACT complex and APE1 sensitizes colon cancer cells to chemotherapy

2018 ◽  
Author(s):  
Heyu Song ◽  
Shrabasti Roychoudhury ◽  
Pranjal Biswas ◽  
Jiping Zeng ◽  
Kishor Bhakat
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Histone Chaperone ◽  
Colon Cancer Cells

scholarly journals Placing the HIRA Histone Chaperone Complex in the Chromatin Landscape

Cell Reports ◽  
2013 ◽  
Vol 3 (4) ◽  
pp. 1012-1019 ◽  
Author(s):  
Nikolay A. Pchelintsev ◽  
Tony McBryan ◽  
Taranjit Singh Rai ◽  
John van Tuyn ◽  
Dominique Ray-Gallet ◽  
...  
Keyword(s):  
Histone Chaperone ◽  
Chaperone Complex
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