scholarly journals Response to: The GPRC5A frameshift variant c.183del is not associated with increased breast cancer risk in BRCA1 mutation carriers

2019 ◽  
Vol 144 (7) ◽  
pp. 1758-1760 ◽  
Author(s):  
Daria R. Bulanova ◽  
Mikko Helenius ◽  
Anna P. Sokolenko ◽  
Sergey G. Kuznetsov ◽  
Evgeny N. Imyanitov
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca1 Mutation ◽  
Mutation Carriers

scholarly journals Breast cancer risk in BRCA1 mutation carriers: insight from mouse models

2013 ◽  
Vol 24 ◽  
pp. viii8-viii12 ◽  
Author(s):  
M.H. Barcellos-Hoff ◽  
D.L. Kleinberg
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Mouse Models ◽  
Brca1 Mutation ◽  
Mutation Carriers

Prophylactic Oophorectomy Reduces Breast Cancer Penetrance During Prospective, Long-Term Follow-Up ofBRCA1Mutation Carriers

2005 ◽  
Vol 23 (34) ◽  
pp. 8629-8635 ◽  
Author(s):  
Joan L. Kramer ◽  
Isela A. Velazquez ◽  
Bingshu E. Chen ◽  
Philip S. Rosenberg ◽  
Jeffery P. Struewing ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Protective Effect ◽  
Brca1 Mutation ◽  
Prophylactic Oophorectomy ◽  
Brca1 Mutations ◽  
Mutation Carriers ◽  
Multiple Case

PurposeBreast cancer penetrance estimates in BRCA1 mutation carriers have varied from 40% to 85%; this heterogeneity has been attributed to variations in risk among different study populations. No study has taken oophorectomy status into account in estimating penetrance. Because prophylactic oophorectomy reduces breast cancer risk by approximately 50%, we hypothesized that population differences in oophorectomy prevalence might significantly influence breast cancer penetrance estimates.MethodsFemales from multiple-case breast/ovarian cancer families that segregate deleterious BRCA1 mutations were observed prospectively for breast cancer incidence and oophorectomy.ResultsWithin this cohort, 33 cases of breast cancer developed in 98 women with deleterious BRCA1 mutations during follow-up, yielding an estimated cumulative lifetime breast cancer risk of 80%. This estimate increased to 94% when the study participants were censored at the time of oophorectomy. Six of the 33 mutation-positive women who underwent oophorectomy during follow-up developed breast cancer, compared with 27 of 65 mutation carriers with intact ovaries (hazard ratio = 0.38; 95% CI, 0.15 to 0.97). Estimates of absolute breast cancer risk demonstrated that the protective effect of oophorectomy was strongest among women who were premenopausal at the time of surgery. When surgical status was ignored, the strong protective effect of oophorectomy, coupled with the high prevalence of the procedure in these families, led to a significantly lower estimate of the breast cancer penetrance in BRCA1 mutation carriers.ConclusionDiffering rates of oophorectomy likely represent an underappreciated basis for a portion of the heterogeneity in estimated breast cancer penetrance described in BRCA mutation carriers, particularly mutation carriers from extensively affected, multiple-case families.

scholarly journals Association of Rad51 polymorphism with DNA repair in BRCA1 mutation carriers and sporadic breast cancer risk

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Luisel J Ricks-Santi ◽  
Lara E Sucheston ◽  
Yang Yang ◽  
Jo L Freudenheim ◽  
Claudine J Isaacs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Sporadic Breast Cancer ◽  
Brca1 Mutation ◽  
Mutation Carriers

scholarly journals Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin

Oncogene ◽  
2009 ◽  
Vol 29 (1) ◽  
pp. 26-33 ◽  
Author(s):  
I Wolf ◽  
Y Laitman ◽  
T Rubinek ◽  
L Abramovitz ◽  
I Novikov ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca1 Mutation ◽  
Mutation Carriers ◽  
Functional Variant ◽  
Risk Modifier

scholarly journals Hormone Replacement Therapy After Oophorectomy and Breast Cancer Risk Among BRCA1 Mutation Carriers

JAMA Oncology ◽  
2018 ◽  
Vol 4 (8) ◽  
pp. 1059 ◽  
Author(s):  
Joanne Kotsopoulos ◽  
Jacek Gronwald ◽  
Beth Y. Karlan ◽  
Tomasz Huzarski ◽  
Nadine Tung ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hormone Replacement Therapy ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Replacement Therapy ◽  
Brca1 Mutation ◽  
Hormone Replacement ◽  
Mutation Carriers

scholarly journals Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers

1999 ◽  
Vol 91 (17) ◽  
pp. 1475-1479 ◽  
Author(s):  
T. R. Rebbeck ◽  
A. M. Levin ◽  
A. Eisen ◽  
C. Snyder ◽  
P. Watson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca1 Mutation ◽  
Prophylactic Oophorectomy ◽  
Mutation Carriers

scholarly journals The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers

2005 ◽  
Vol 27 (3) ◽  
pp. 599-605 ◽  
Author(s):  
Susan Colilla ◽  
Philip W. Kantoff ◽  
Susan L. Neuhausen ◽  
Andrew K. Godwin ◽  
Mary B. Daly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Brca1 Mutation ◽  
Joint Effect ◽  
Mutation Carriers
Sign in / Sign up

Export Citation Format

Share Document