scholarly journals A BAP31 intrabody induces gastric cancer cell death by inhibiting p27 kip1 proteasome degradation

2019 ◽  
Vol 144 (8) ◽  
pp. 2051-2062 ◽  
Author(s):  
Jing Chen ◽  
Haotian Guo ◽  
Haitao Jiang ◽  
Mwichie Namusamba ◽  
Changli Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Proteasome Degradation ◽  
Cancer Cell Death ◽  
P27 Kip1

Mo1043 PORPHYRIN COMBINED USE ACCELERATES CHEMOTHERAPEUTIC EFFECTS FOR THE GASTRIC CANCER CELL DEATH.

2020 ◽  
Vol 158 (6) ◽  
pp. S-766-S-767
Author(s):  
Daisuke Matano ◽  
Hiromu Ito ◽  
YOSHIKI KOMATSU ◽  
Hiromi Kurokawa ◽  
Hirofumi Matsui
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Death ◽  
Combined Use

RKIP promotes cisplatin-induced gastric cancer cell death through NF-κB/Snail pathway

Tumor Biology ◽  
2014 ◽  
Vol 36 (3) ◽  
pp. 1445-1453 ◽  
Author(s):  
Hongyi Liu ◽  
Peng Li ◽  
Bing Li ◽  
Peng Sun ◽  
Jiajin Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Death

scholarly journals Protective role of autophagy in matrine-induced gastric cancer cell death

2013 ◽  
Vol 42 (4) ◽  
pp. 1417-1426 ◽  
Author(s):  
YUMIN LI ◽  
JUNQIANG ZHANG ◽  
HAIZHEN MA ◽  
XIAOHUI CHEN ◽  
TAO LIU ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Protective Role ◽  
Cancer Cell Death

Upregulation of miR-133a-3p enhances Bufothionine-induced gastric cancer cell death by modulating IGF1R/PI3K/Akt signal pathway mediated ER stress

Life Sciences ◽  
2020 ◽  
Vol 259 ◽  
pp. 118180
Author(s):  
Zhi-Hao Hu ◽  
Guo-Jun Wang ◽  
Rui-Xin Li ◽  
Tian-Yu Zhu ◽  
Zhuo-Yin Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Er Stress ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Signal Pathway ◽  
Cancer Cell Death

miR-34a regulates cisplatin-induce gastric cancer cell death by modulating PI3K/AKT/survivin pathway

Tumor Biology ◽  
2013 ◽  
Vol 35 (2) ◽  
pp. 1287-1295 ◽  
Author(s):  
Weiguo Cao ◽  
Weiping Yang ◽  
Rong Fan ◽  
Hao Li ◽  
Jinsong Jiang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Cancer Cell Death

Three novel Schiff base transition metal(II) complexes induce gastric cancer cell death through ROS-mediated apoptotic pathway

2019 ◽  
Vol 72 (14) ◽  
pp. 2310-2325 ◽  
Author(s):  
Xiu-Heng Qi ◽  
Zhen-Ming Wu ◽  
Shuai-Bing Wang ◽  
Bao-Xin Wang ◽  
Ling-Ling Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Schiff Base ◽  
Transition Metal ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Apoptotic Pathway ◽  
Cancer Cell Death ◽  
Base Transition

Hyaluronic acid receptor-targetable imidazolized nanovectors for induction of gastric cancer cell death by RNA interference

Biomaterials ◽  
2013 ◽  
Vol 34 (17) ◽  
pp. 4327-4338 ◽  
Author(s):  
Eunjung Kim ◽  
Jaemoon Yang ◽  
Hyun-Ouk Kim ◽  
Yonghee An ◽  
Eun-Kyung Lim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Death ◽  
Hyaluronic Acid ◽  
Rna Interference ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Acid Receptor ◽  
Cancer Cell Death

Single-chain Antibody Against Reg4 Suppresses Gastric Cancer Cell Growth and Enhances 5-FU-induced Cell Death in vitro

2019 ◽  
Vol 19 (5) ◽  
pp. 610-619 ◽  
Author(s):  
Xue-Qing Zhang ◽  
Lu-Ting Yu ◽  
Pei Du ◽  
Tian-Qi Yin ◽  
Zhi-Yuan Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Proliferation ◽  
Cell Death ◽  
Cancer Cell ◽  
Gastric Cancer Cell ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Ags Cells ◽  
Thiazolyl Blue Tetrazolium Bromide

Background:Regenerating islet-derived gene family member 4 (Reg4), a well-investigated growth factor in the regenerative pancreas, has recently been reported to be highly associated with a majority of gastrointestinal cancers. Pathological hyper-expression or artificial over-expression of Reg4 causes acceleration of tumor growth, migration, and resistance to chemotherapeutic 5-Fluorouracil (5-FU). Until now, no method has been successfully established for eliminating the effects of Reg4 protein.Methods:This study reports the production of an engineered immunoglobin, a single-chain variable fragment (scFv-Reg4), to specifically bind Reg4 and block the bioactivity. The complementary-determining regions (CDRs) against Reg4 were assigned using MOE and ZDOCK servers. The binding affinity (KD) was determined by bio-layer interferometry (BLI). MKN45 and AGS cell proliferation was determined by Thiazolyl blue tetrazolium bromide (MTT) method and the cell apoptosis was detected by flow cytometry assay.Results:The KD of scFv-Reg4 to Reg4 was determined to be 1.91×10-8. In MKN45 and AGS cell lines, scFv- Reg4 depressed Reg4-stimulated cell proliferation and the inhibitory rates were 27.7±1.5% and 17.3±2.6%, respectively. Furthermore, scFv significantly enhanced 5-FU-induced cell death, from 23.0±1.0% to 28.4±1.2% in MKN45 and 28.2±0.7% to 36.6±0.6% in AGS cells. Treatment with scFv alone could lyse cancer cells to a certain extent, but no significance has been observed.Conclusion:The single-chain antibody (scFv-Reg4) significantly inhibited gastric cancer cell proliferation and synergistically enhanced the lethal effect of 5-FU. Thus, traditional chemo-/radio- therapeutics supplemented with scFv-Reg4 may provide advances in the strategy for gastrointestinal cancer treatment.

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