scholarly journals Genetic variation analysis in a follow-up study of gastric cancer precursor lesions confirms the association of MUC2 variants with the evolution of the lesions and identifies a significant association with NFKB1 and CD14

2018 ◽  
Vol 143 (11) ◽  
pp. 2777-2786 ◽  
Author(s):  
Osmel Companioni ◽  
Catalina Bonet ◽  
Nadia García ◽  
María José Ramírez-Lázaro ◽  
Sergio Lario ◽  
...  
1981 ◽  
Vol 14 (10) ◽  
pp. 1409-1413
Author(s):  
Hideaki NISHIDOI ◽  
Osamu KIMURA ◽  
Tsuneyuki OKAMOTO ◽  
Hideaki TAMURA ◽  
Nobuaki KAIBARA ◽  
...  

Genes ◽  
2019 ◽  
Vol 10 (2) ◽  
pp. 82 ◽  
Author(s):  
Daniela Scarabino ◽  
Martina Peconi ◽  
Franca Pelliccia ◽  
Rosa Maria Corbo

We investigated the possible influence of TERC and TERT genetic variation and leukocyte telomere length (LTL) on human lifespan. Four polymorphisms of TERT and three polymorphisms of TERC were examined in a sample of elderly subjects (70–100 years). After nine years of follow-up, mortality data were collected, and sub-samples of long-lived/not long-lived were defined. TERT VNTR MNS16A L/L genotype and TERT rs2853691 A/G or G/G genotypes were found to be associated with a significantly higher risk to die before the age of 90 years, and with a significantly lower age at death. The association between lifespan and LTL at baseline was analyzed in a subsample of 163 subjects. Age at baseline was inversely associated with LTL (p < 0.0001). Mean LTL was greater in the subjects still living than in those no longer living at follow-up (0.79 T/S ± 0.09 vs 0.63 T/S ± 0.08, p < 0.0001). Comparison of age classes showed that, among the 70–79-year-olds, the difference in mean LTL between those still living and those no longer living at follow-up was greater than among the 80–90-year-olds. Our data provide evidence that shorter LTL at baseline may predict a shorter lifespan, but the reliability of LTL as a lifespan biomarker seems to be limited to a specific age (70–79 years).


2009 ◽  
Vol 12 (3) ◽  
pp. 158-163 ◽  
Author(s):  
Shigeto Mizuno ◽  
Masao Kobayashi ◽  
Shohken Tomita ◽  
Ikuya Miki ◽  
Atsuhiro Masuda ◽  
...  

1989 ◽  
Vol 10 (3) ◽  
pp. 147-150
Author(s):  
Hiroshi Harada ◽  
Kazuhiro Ohmagari ◽  
Masahiro Inumaru ◽  
Hiroshi Ikezono ◽  
Ei Sasaki ◽  
...  

2018 ◽  
Vol 26 (31) ◽  
pp. 1812-1817 ◽  
Author(s):  
Hua-Ying Zhang ◽  
Xin-Yu Huang ◽  
Hui-Guang Xue ◽  
Ai-Hua Yang ◽  
Xue-Guo Sun ◽  
...  

1967 ◽  
Vol 2 (4) ◽  
pp. 336-336
Author(s):  
T. Shoji ◽  
K. Suzuki ◽  
R. Nakayama ◽  
M. Yokosuka

1996 ◽  
Vol 29 (7) ◽  
pp. 1591-1596
Author(s):  
Yukihide Kanemitsu ◽  
Takehiro Hachisuka ◽  
Yasushi Kato ◽  
Masayuki Miyauchi ◽  
Masahiko Shinohara ◽  
...  

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