scholarly journals Prognostic roles for IL ‐2‐producing and CD 69 + T cell subsets in colorectal cancer patients

2018 ◽  
Vol 143 (8) ◽  
pp. 2008-2016 ◽  
Author(s):  
Edward S. Taylor ◽  
John L. McCall ◽  
Shirley Shen ◽  
Adam Girardin ◽  
Fran M. Munro ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Cancer Patients ◽  
T Cell Subsets ◽  
Colorectal Cancer Patients

scholarly journals Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients

2019 ◽  
Vol 10 ◽  
Author(s):  
Salman M. Toor ◽  
Khaled Murshed ◽  
Mahmood Al-Dhaheri ◽  
Mahwish Khawar ◽  
Mohamed Abu Nada ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Cancer Patients ◽  
T Cell Subsets ◽  
Cd4 T Cell ◽  
Immune Checkpoints ◽  
Colorectal Cancer Patients

Su2037 CD8+ T-Cell Infiltration in Epithelial and Stromal Tissues of MSI Colorectal Cancer Patients

2016 ◽  
Vol 150 (4) ◽  
pp. S617
Author(s):  
Lakshmi Kannan ◽  
Hassan Ashktorab ◽  
Edward L. Lee ◽  
Babak Shokrani ◽  
Akbar Soleimani ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Cancer Patients ◽  
Cd8 T Cell ◽  
Cell Infiltration ◽  
T Cell Infiltration ◽  
Colorectal Cancer Patients

scholarly journals Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests

2006 ◽  
Vol 17 (6) ◽  
pp. 974-980 ◽  
Author(s):  
W.J. Lesterhuis ◽  
I.J.M. de Vries ◽  
D.H. Schuurhuis ◽  
A.C.I. Boullart ◽  
J.F.M. Jacobs ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dendritic Cells ◽  
T Cell ◽  
Cancer Patients ◽  
T Cell Responses ◽  
Skin Tests ◽  
Cell Responses ◽  
Colorectal Cancer Patients

scholarly journals Induction of Both CD8+ and CD4+ T-Cell–Mediated Responses in Colorectal Cancer Patients by Colon Antigen-1

2008 ◽  
Vol 14 (22) ◽  
pp. 7292-7303 ◽  
Author(s):  
Cristina Maccalli ◽  
Veronica Di Cristanziano ◽  
Valentina Fodale ◽  
Domenico Corsi ◽  
Giuseppina D'Agostino ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
T Cell ◽  
Cancer Patients ◽  
Cd4 T Cell ◽  
Colorectal Cancer Patients

scholarly journals Distinct epigenetic features of tumor-reactive CD8+ T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Rui Yang ◽  
Sijin Cheng ◽  
Nan Luo ◽  
Ranran Gao ◽  
Kezhuo Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
T Cells ◽  
T Cell ◽  
Cancer Patients ◽  
Cd8 T Cells ◽  
Methylation Status ◽  
Effector Memory ◽  
Binding Motif ◽  
Colorectal Cancer Patients

Abstract Background Tumor-reactive CD8+ tumor-infiltrating lymphocytes (TILs) represent a subtype of T cells that can recognize and destroy tumor specifically. Understanding the regulatory mechanism of tumor-reactive CD8+ T cells has important therapeutic implications. Yet the DNA methylation status of this T cell subtype has not been elucidated. Results In this study, we segregate tumor-reactive and bystander CD8+ TILs, as well as naïve and effector memory CD8+ T cell subtypes as controls from colorectal cancer patients, to compare their transcriptome and methylome characteristics. Transcriptome profiling confirms previous conclusions that tumor-reactive TILs have an exhausted tissue-resident memory signature. Whole-genome methylation profiling identifies a distinct methylome pattern of tumor-reactive CD8+ T cells, with tumor-reactive markers CD39 and CD103 being specifically demethylated. In addition, dynamic changes are observed during the transition of naïve T cells into tumor-reactive CD8+ T cells. Transcription factor binding motif enrichment analysis identifies several immune-related transcription factors, including three exhaustion-related genes (NR4A1, BATF, and EGR2) and VDR, which potentially play an important regulatory role in tumor-reactive CD8+ T cells. Conclusion Our study supports the involvement of DNA methylation in shaping tumor-reactive and bystander CD8+ TILs, and provides a valuable resource for the development of novel DNA methylation markers and future therapeutics.

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