scholarly journals Risk factors associated with gastroenteropancreatic neuroendocrine tumors in a cohort of 2.3 million Israeli adolescents

2018 ◽  
Vol 143 (8) ◽  
pp. 1876-1883 ◽  
Author(s):  
Lior H. Katz ◽  
Zohar Levi ◽  
Gilad Twig ◽  
Jeremy D. Kark ◽  
Adi Leiba ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neuroendocrine Tumors ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Factors Associated

scholarly journals Risk factors associated with the progression and metastases of hindgut neuroendocrine tumors: a retrospective study

BMC Cancer ◽  
2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Yoichiro Okubo ◽  
Rika Kasajima ◽  
Masaki Suzuki ◽  
Yohei Miyagi ◽  
Osamu Motohashi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Neuroendocrine Tumors ◽  
Factors Associated

Evaluation of the risk factors associated with rectal neuroendocrine tumors: a big data analytic study from a health screening center

2016 ◽  
Vol 51 (12) ◽  
pp. 1112-1121 ◽  
Author(s):  
Jeung Hui Pyo ◽  
Sung Noh Hong ◽  
Byung-Hoon Min ◽  
Jun Haeng Lee ◽  
Dong Kyung Chang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Big Data ◽  
Neuroendocrine Tumors ◽  
Health Screening ◽  
Analytic Study ◽  
Factors Associated ◽  
Data Analytic

Defining the role of lymphadenectomy for pancreatic neuroendocrine tumors: An eight institution study of 695 patients from the U.S. Neuroendocrine Tumor Study Group.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 212-212
Author(s):  
Alexandra G Lopez-Aguiar ◽  
Mohammad Zaidi ◽  
Mary Dillhoff ◽  
Eliza W Beal ◽  
George A. Poultsides ◽  
...  
Keyword(s):  
Risk Factors ◽  
Distal Pancreatectomy ◽  
Neuroendocrine Tumors ◽  
Tumor Size ◽  
Pancreatic Neuroendocrine Tumors ◽  
Ki 67 ◽  
Curative Intent ◽  
Factors Associated ◽  
Regional Lymphadenectomy ◽  
Preoperative Factors

212 Background: Preoperative factors that reliably predict lymph node (LN) metastases in pancreatic neuroendocrine tumors (PanNETs) are unclear. The number of LNs needed to accurately stage PanNETs has not been defined. Methods: Patients who underwent curative-intent resection of primary non-functional PanNETs at 8 institutions from 2000-2016 were analyzed. Tumors with poor differentiation and Ki-67 > 20% were excluded. Preoperative factors associated with LN metastases were identified. A procedure specific target for LN retrieval to accurately stage patients was determined. Results: Of 2182 pts with GI NETs, 695 underwent resection of PanNETs. 33% of tumors were proximal (head/uncinate), and 67% were distal (neck/body/tail). 26% of pts (n = 158) had LN+ disease, which was associated with worse 5-yr recurrence-free survival (RFS) (60% vs 86%; p < 0.001). Increasing number of +LNs was not associated with worse RFS. Preoperative factors associated with +LNs included tumor size ≥2 cm (OR 6.6; p < 0.001), proximal location (OR 2.5; p < 0.001), moderate vs well differentiation (OR 2.1; p = 0.006), and Ki-67≥3% (OR 3.1; p < 0.001). LN metastases were also present in tumors without these risk factors: < 2cm (9%), distal location (19%), well differentiated (23%), and Ki-67 < 3% (16%). Median LN retrieval was 13 for pancreatoduodenectomy (PD), but only 9 for distal pancreatectomy (DP). Given that PD routinely includes a complete regional lymphadenectomy, a minimum number of LNs to accurately stage pts was not identified. For DP, however, removal of < 7 LNs failed to discriminate 5-yr RFS between LN (+) and (-) pts ( < 7 LNs: 72% vs 83%, p = 0.198; ≥7 LNs: 67% vs 86%, p = 0.002). Conclusions: Tumor size ≥2 cm, proximal location, moderate differentiation, and Ki-67≥3% are preoperative factors that predict LN positivity in resected non-functional PanNETs. Given the 9-23% incidence of LN metastases in patients without such risk factors, routine regional lymphadenectomy should be considered. Pancreatoduodenectomy inherently includes sufficient LN retrieval, while distal pancreatectomy should aim to remove ≥7 LNs for accurate staging.

Peritoneal Metastases from Gastroenteropancreatic Neuroendocrine Tumors: Incidence, Risk Factors and Prognosis

2017 ◽  
Vol 24 (8) ◽  
pp. 2199-2205 ◽  
Author(s):  
Ariana Madani ◽  
Irene Thomassen ◽  
Yvette R. B. M. van Gestel ◽  
Jarmila D. W. van der Bilt ◽  
Harm R. Haak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neuroendocrine Tumors ◽  
Peritoneal Metastases ◽  
Gastroenteropancreatic Neuroendocrine Tumors ◽  
Incidence Risk

scholarly journals Risk factors associated with neuroendocrine tumors: A U.S.-based case-control study

2008 ◽  
Vol 123 (4) ◽  
pp. 867-873 ◽  
Author(s):  
Manal M. Hassan ◽  
Alexandria Phan ◽  
Donghui Li ◽  
Cecile G. Dagohoy ◽  
Colleen Leary ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neuroendocrine Tumors ◽  
Case Control Study ◽  
Case Control ◽  
Factors Associated ◽  
Control Study

scholarly journals Risk Factors Associated with Rectal Neuroendocrine Tumors: A Cross-Sectional Study

2014 ◽  
Vol 23 (7) ◽  
pp. 1406-1413 ◽  
Author(s):  
Yoon Suk Jung ◽  
Kyung Eun Yun ◽  
Yoosoo Chang ◽  
Seungho Ryu ◽  
Jung Ho Park ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neuroendocrine Tumors ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Factors Associated
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