scholarly journals P‐glycoprotein (MDR1/ABCB1) restricts brain accumulation and cytochrome P450‐3A (CYP3A) limits oral availability of the novel ALK/ROS1 inhibitor lorlatinib

2018 ◽  
Vol 143 (8) ◽  
pp. 2029-2038 ◽  
Author(s):  
Wenlong Li ◽  
Rolf W. Sparidans ◽  
Yaogeng Wang ◽  
Maria C. Lebre ◽  
Els Wagenaar ◽  
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Keyword(s):  
Cytochrome P450 ◽  
The Novel ◽  
Cytochrome P450 3A ◽  
P Glycoprotein ◽  
Oral Availability

scholarly journals P-glycoprotein and cytochrome P450 3A act together in restricting the oral bioavailability of paclitaxel

2012 ◽  
Vol 132 (10) ◽  
pp. 2439-2447 ◽  
Author(s):  
Jeroen J.M.A. Hendrikx ◽  
Jurjen S. Lagas ◽  
Hilde Rosing ◽  
Jan H.M. Schellens ◽  
Jos H. Beijnen ◽  
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Cytochrome P450 ◽  
Oral Bioavailability ◽  
Cytochrome P450 3A ◽  
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Effect of genistein on the activities of cytochrome P450 3A and P-glycoprotein in Chinese healthy participants

Xenobiotica ◽  
2011 ◽  
Vol 42 (2) ◽  
pp. 173-178 ◽  
Author(s):  
C.-Q. Xiao ◽  
R. Chen ◽  
J. Lin ◽  
G. Wang ◽  
Y. Chen ◽  
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Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 3A ◽  
P Glycoprotein ◽  
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Involvement of P-glycoprotein and cytochrome P450 3A in the metabolism of florfenicol of rabbits

2011 ◽  
Vol 35 (2) ◽  
pp. 202-205 ◽  
Author(s):  
N. LIU ◽  
M. GUO ◽  
F. MO ◽  
Y.-H. SUN ◽  
Z. YUAN ◽  
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Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 3A ◽  
P Glycoprotein

scholarly journals Cytochrome P450 3A and P-glycoprotein drug-drug interactions with voclosporin

2014 ◽  
Vol 77 (6) ◽  
pp. 1039-1050 ◽  
Author(s):  
Spencer Y. Ling ◽  
Robert B. Huizinga ◽  
Patrick R. Mayo ◽  
Richard Larouche ◽  
Derrick G. Freitag ◽  
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Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Cytochrome P450 3A ◽  
P Glycoprotein
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