scholarly journals Targeting the MET oncogene by concomitant inhibition of receptor and ligand via an antibody‐“decoy” strategy

2018 ◽  
Vol 143 (7) ◽  
pp. 1774-1785 ◽  
Author(s):  
Cristina Basilico ◽  
Chiara Modica ◽  
Federica Maione ◽  
Elisa Vigna ◽  
Paolo M. Comoglio
Keyword(s):  
Met Oncogene

Expression of the MET Oncogene in Human Tumors

1992 ◽  
pp. 11-21
Author(s):  
M. F. Di Renzo ◽  
M. Prat ◽  
M. Olivero ◽  
T. Crepaldi ◽  
P. M. Comoglio
Keyword(s):  
Human Tumors ◽  
Met Oncogene

scholarly journals A point mutation in the MET oncogene abrogates metastasis without affecting transformation

1997 ◽  
Vol 94 (25) ◽  
pp. 13868-13872 ◽  
Author(s):  
S. Giordano ◽  
A. Bardelli ◽  
Z. Zhen ◽  
S. Menard ◽  
C. Ponzetto ◽  
...  
Keyword(s):  
Point Mutation ◽  
Met Oncogene

scholarly journals Dimerization mediated through a leucine zipper activates the oncogenic potential of the met receptor tyrosine kinase.

1993 ◽  
Vol 13 (11) ◽  
pp. 6711-6722 ◽  
Author(s):  
G A Rodrigues ◽  
M Park
Keyword(s):  
Tyrosine Kinase ◽  
Receptor Tyrosine Kinase ◽  
Tyrosine Kinases ◽  
Leucine Zipper ◽  
Kinase Domain ◽  
Site Directed Mutagenesis ◽  
Leucine Zipper Motif ◽  
Transforming Activity ◽  
Met Oncogene ◽  
Hepatocyte Growth

Oncogenic activation of the met (hepatocyte growth factor/scatter factor) receptor tyrosine kinase involves a genomic rearrangement that generates a hybrid protein containing tpr-encoded sequences at its amino terminus fused directly to the met-encoded receptor kinase domain. Deletion of Tpr sequences abolishes the transforming ability of this protein, implicating this region in oncogenic activation. We demonstrate, by site-directed mutagenesis and coimmunoprecipitation experiments, that a leucine zipper motif within Tpr mediates dimerization of the tpr-met product and is essential for the transforming activity of the met oncogene. By analogy with ligand-stimulated activation of receptor tyrosine kinases, we propose that constitutive dimerization mediated by a leucine zipper motif within Tpr is responsible for oncogenic activation of the Met kinase. The possibility that this mechanism of activation represents a paradigm for a class of receptor tyrosine kinase oncogenes activated by DNA rearrangement is discussed.

scholarly journals The Hgfr/Met oncogene is the target for gene amplification in DMBA-induced rat sarcomas

10.1038/87114 ◽  
2001 ◽  
Vol 27 (S4) ◽  
pp. 59-59
Author(s):  
Khalil Helou ◽  
Anna Walentinsson ◽  
Marija Kost-Alimova ◽  
Göran Levan
Keyword(s):  
Gene Amplification ◽  
Met Oncogene

scholarly journals Targeting the MET oncogene in cancer and metastases

2010 ◽  
Vol 19 (11) ◽  
pp. 1381-1394 ◽  
Author(s):  
Giulia M Stella ◽  
Silvia Benvenuti ◽  
Paolo M Comoglio
Keyword(s):  
Met Oncogene

scholarly journals Met oncogene aberrant expression in canine osteosarcoma

2000 ◽  
Vol 18 (2) ◽  
pp. 253-256 ◽  
Author(s):  
R. Ferracini ◽  
P. Angelini ◽  
E. Cagliero ◽  
A. Linari ◽  
M. Martano ◽  
...  
Keyword(s):  
Aberrant Expression ◽  
Canine Osteosarcoma ◽  
Met Oncogene

Mapping of the c-met oncogene amplicon in a human gastric carcinoma cell line

1991 ◽  
Vol 52 (2) ◽  
pp. 236
Author(s):  
G. Rege-Cambrin ◽  
C. Ponzetto ◽  
G. Della Valle ◽  
F. Peverali ◽  
P. Scaravaglio ◽  
...  
Keyword(s):  
Gastric Carcinoma ◽  
Cell Line ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Gastric Carcinoma Cell ◽  
Gastric Carcinoma Cell Line ◽  
Human Gastric Carcinoma ◽  
Met Oncogene

scholarly journals A preclinical algorithm of soluble surrogate biomarkers that correlate with therapeutic inhibition of the MET oncogene in gastric tumors

2011 ◽  
Vol 130 (6) ◽  
pp. 1357-1366 ◽  
Author(s):  
Davide Torti ◽  
Francesco Sassi ◽  
Francesco Galimi ◽  
Stefania Gastaldi ◽  
Timothy Perera ◽  
...  
Keyword(s):  
Gastric Tumors ◽  
Met Oncogene
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