scholarly journals Colony stimulating factor 1 receptor blockade improves the efficacy of chemotherapy against human neuroblastoma in the absence of T lymphocytes

2018 ◽  
Vol 143 (6) ◽  
pp. 1483-1493 ◽  
Author(s):  
Matthew W. Webb ◽  
Jianping Sun ◽  
Michael A. Sheard ◽  
Wei‐Yao Liu ◽  
Hong‐Wei Wu ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Receptor Blockade ◽  
Colony Stimulating Factor ◽  
Human Neuroblastoma ◽  
Stimulating Factor

scholarly journals Syngeneic transplantation with peripheral blood mononuclear cells collected after the administration of recombinant human granulocyte colony-stimulating factor

Blood ◽  
1993 ◽  
Vol 82 (7) ◽  
pp. 1981-1984 ◽  
Author(s):  
CH Weaver ◽  
CD Buckner ◽  
K Longin ◽  
FR Appelbaum ◽  
S Rowley ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Median Time ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells ◽  
Stimulating Factor

Abstract Five syngeneic transplants were performed in four patients following myeloablative therapy using unmodified peripheral blood mononuclear cells (PBMCs) collected after the administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) to normal donors. The only toxicity experienced by the four normal donors was bone pain. Four patients received two collections of PBMCs, and a second transplant was performed in one patient with one collection. The patients received a median of 20.53 x 10(8) total nucleated cells/kg (range 20 to 25.5), 11.3 x 10(8) total mononuclear cells/kg (range 6.52 to 17.2), 113.1 x 10(4)/kg CFU-GM (range 46.7 to 211.8) and 9.6 x 10(6) CD34+ cells/kg (range 1.6 to 12.6) Post-transplant growth factors were not administered. The median time to an absolute neutrophil count greater than 0.5 x 10(9)/L was 14 days (range 10 to 18). The median time to platelet transfusion independence was 11 days (range 10 to 13). Two patients had the number of CD3+ T lymphocytes determined in the pheresis product. An average of 3.04 x 10(10) CD3+ cells were collected per pheresis. This represents an approximate 1 log increase over the number of T lymphocytes in a typical bone marrow transplant. Rh-GCSF can be used to mobilize peripheral blood progenitor cells from normal donors with minimal toxicity. Studies of allogeneic transplants using PBMCs collected after rhG-CSF administration to determine permanent grafting ability and the incidence and severity of graft-versus-host disease are warranted.

Frequency and activity of immune interferon (IFN-γ)-and colony-stimulating factor-producing human peripheral blood T lymphocytes

1984 ◽  
Vol 14 (4) ◽  
pp. 368-373 ◽  
Author(s):  
Ursula Kees ◽  
Brigitte Kaltmann ◽  
Fabrizio Marcucci ◽  
Lothar Hültner ◽  
Fritz Staber ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Colony Stimulating Factor ◽  
Immune Interferon ◽  
Ifn Γ ◽  
Stimulating Factor

scholarly journals Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis

2016 ◽  
Vol 18 (1) ◽  
Author(s):  
Samuel Garcia ◽  
Linda M. Hartkamp ◽  
B Malvar-Fernandez ◽  
Inge E. van Es ◽  
Haishan Lin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Receptor Blockade ◽  
Murine Models ◽  
Colony Stimulating Factor ◽  
Stimulating Factor
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