scholarly journals A TGF‐ β 1 genetic variant at the miRNA187 binding site significantly modifies risk of HPV16‐associated oropharyngeal cancer

2018 ◽  
Vol 143 (6) ◽  
pp. 1327-1334 ◽  
Author(s):  
Ye Tao ◽  
Erich M. Sturgis ◽  
Zhigang Huang ◽  
Yan Sun ◽  
Kristina R. Dahlstrom ◽  
...  
Keyword(s):  
Binding Site ◽  
Oropharyngeal Cancer ◽  
Genetic Variant

scholarly journals A genetic variant within MDM4 3′UTR miRNA binding site is associated with HPV16‐positive tumors and survival of oropharyngeal cancer

2019 ◽  
Vol 58 (12) ◽  
pp. 2276-2285 ◽  
Author(s):  
Yang Zhang ◽  
Erich M. Sturgis ◽  
Peng Wei ◽  
Hongliang Liu ◽  
Ziqiao Wang ◽  
...  
Keyword(s):  
Binding Site ◽  
Oropharyngeal Cancer ◽  
Genetic Variant ◽  
Mirna Binding Site

scholarly journals A genetic variant of miR-148a binding site in the SCRN1 3′-UTR is associated with susceptibility and prognosis of gastric cancer

2014 ◽  
Vol 4 (1) ◽  
Author(s):  
Peng Song ◽  
Haixia Zhu ◽  
Dong Zhang ◽  
Haiyan Chu ◽  
Dongmei Wu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Binding Site ◽  
Genetic Variant

A genetic variant of miR‐335 binding site in the ERBB4 3′‐UTR is associated with prognosis of ovary cancer

2018 ◽  
Vol 119 (7) ◽  
pp. 5135-5142 ◽  
Author(s):  
Ping Wei ◽  
Ling Li ◽  
Zhihu Zhang ◽  
Wei Zhang ◽  
Ming Liu ◽  
...  
Keyword(s):  
Binding Site ◽  
Genetic Variant ◽  
Ovary Cancer

Genetic variant in the microRNA binding site of DOK3 (rs2279398G>A) and susceptibility to colorectal cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 1537-1537
Author(s):  
Jong Gwang Kim ◽  
Hyo-Sung Jeon ◽  
Byung Woog Kang ◽  
Yee Soo Chae ◽  
Soo Jung Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Binding Site ◽  
Genetic Variant

A miR-29c binding site genetic variant in the 3′-untranslated region of LAMTOR3 gene is associated with gastric cancer risk

2015 ◽  
Vol 69 ◽  
pp. 70-75 ◽  
Author(s):  
Peng Song ◽  
Weizhi Wang ◽  
Guoquan Tao ◽  
Haiyan Chu ◽  
Meilin Wang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Risk ◽  
Binding Site ◽  
Untranslated Region ◽  
Genetic Variant ◽  
Gastric Cancer Risk

scholarly journals Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shankar Dhamodharan ◽  
Mathew Maria Rose ◽  
Sundaram Reddy Chakkarappan ◽  
Karuppiah Vijayamuthuramalingam Umadharshini ◽  
Ramalingam Arulmurugan ◽  
...  
Keyword(s):  
Alternative Splicing ◽  
Binding Site ◽  
Genetic Variant ◽  
Kinase Inhibitor ◽  
Bioinformatic Analysis ◽  
Therapeutic Drug ◽  
Similar Frequency ◽  
Oral Cancer Patients ◽  
Exon 20 ◽  
High Level

AbstractTyrosine kinase inhibitor is an effective chemo-therapeutic drug against tumors with deregulated EGFR pathway. Recently, a genetic variant rs10251977 (G>A) in exon 20 of EGFR reported to act as a prognostic marker for HNSCC. Genotyping of this polymorphism in oral cancer patients showed a similar frequency in cases and controls. EGFR-AS1 expressed significantly high level in tumors and EGFR-A isoform expression showed significant positive correlation (r = 0.6464, p < 0.0001) with reference to EGFR-AS1 expression levels, consistent with larger TCGA HNSCC tumor dataset. Our bioinformatic analysis showed enrichment of alternative splicing marks H3K36me3 and presence of intronic polyA sites spanning around exon 15a and 15b of EGFR facilitates skipping of exon 15b, thereby promoting the splicing of EGFR-A isoform. In addition, high level expression of PTBP1 and its binding site in EGFR and EGFR-AS1 enhances the expression of EGFR-A isoform (r = 0.7404, p < 0.0001) suggesting that EGFR-AS1 expression modulates the EGFR-A and D isoforms through alternative splicing. In addition, this polymorphism creates a binding site for miR-891b in EGFR-AS1 and may negatively regulate the EGFR-A. Collectively, our results suggested the presence of genetic variant in EGFR-AS1 modulates the expression of EGFR-D and A isoforms.

A genetic variant located in the miR-532-5p-binding site of TGFBR1 is associated with the colorectal cancer risk

2018 ◽  
Vol 54 (2) ◽  
pp. 141-148 ◽  
Author(s):  
Dongying Gu ◽  
Shuwei Li ◽  
Mulong Du ◽  
Cuiju Tang ◽  
Haiyan Chu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Binding Site ◽  
Genetic Variant ◽  
Colorectal Cancer Risk

A RAD52 genetic variant located in a miRNA binding site is associated with glioma risk in Han Chinese

2014 ◽  
Vol 120 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Chao Lu ◽  
Yi-Dong Chen ◽  
Sichong Han ◽  
Jinyu Wei ◽  
Yunxia Ge ◽  
...  
Keyword(s):  
Binding Site ◽  
Genetic Variant ◽  
Han Chinese ◽  
Mirna Binding Site ◽  
Glioma Risk
Sign in / Sign up

Export Citation Format

Share Document