scholarly journals Genome-wide profiling of normal gastric mucosa identifiesHelicobacter pylori- and cancer-associated DNA methylome changes

2018 ◽  
Vol 143 (3) ◽  
pp. 597-609 ◽  
Author(s):  
Hae Dong Woo ◽  
Nora Fernandez-Jimenez ◽  
Akram Ghantous ◽  
Davide Degli Esposti ◽  
Cyrille Cuenin ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Normal Gastric Mucosa ◽  
Dna Methylome ◽  
Genome Wide

scholarly journals Comparison of the protein expression of calpain-1, calpain-2, calpastatin and calmodulin between gastric cancer and normal gastric mucosa

2017 ◽  
Vol 14 (3) ◽  
pp. 3705-3710 ◽  
Author(s):  
Bide Liu ◽  
Yu Zhou ◽  
Dan Lu ◽  
Yong Liu ◽  
Si-Quan Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Mucosa ◽  
Protein Expression ◽  
Normal Gastric Mucosa ◽  
Calpain 2

scholarly journals Correlation between Fas and FasL proteins expression in normal gastric mucosa and gastric cancer

2011 ◽  
Vol 49 (1) ◽  
pp. 142-147 ◽  
Author(s):  
Mariusz Gryko ◽  
Katarzyna Guzińska-Ustymowicz ◽  
Anna Pryczynicz ◽  
Dariusz Cepowicz ◽  
Adam Kukliński ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gastric Mucosa ◽  
Normal Gastric Mucosa

scholarly journals Helicobacter pylori and Epstein–Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Fasciana Teresa ◽  
Nicola Serra ◽  
Giuseppina Capra ◽  
Chiara Mascarella ◽  
Cesare Gagliardi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Epstein Barr Virus ◽  
Normal Gastric Mucosa ◽  
Gastric Diseases ◽  
Barr Virus ◽  
Genes Encoding ◽  
Epstein Barr

Introduction. Helicobacter pylori and Epstein–Barr virus (EBV) infection have recently been shown to be associated with gastric diseases. Polymorphisms in genes encoding cytokines such as interleukin 10 (IL-10) and interleukin 1 Receptor (IL-1RN) influence cytokine secretion levels and appear to contribute to the risk of developing gastroduodenal diseases. To our knowledge, this is the first preliminary study to address the association of coinfection with H. pylori and EBV and their correlation with genetic predisposition in the development of gastric diseases. Methods. Gastric biopsy samples of 96 patients with different gastric diseases were used. Results. Our results showed that the rate of coinfection was higher in patients with gastric cancer than in patients with normal gastric mucosa, active chronic gastritis, and MALT lymphoma. As regards the characterization of H. pilory strains, the polymorphism s1m1i1 of vacA gene was more frequent in patients with MALT Lymphoma in comparison to others, while the polymorphism s2m2i2 was most frequent in patients with normal gastric mucosa. In addition, patients who tested positive for the cagA gene were more frequently those affected with gastric cancer than those with inactive chronic gastritis. Similarly, the patients with oipA gene ON were more frequently those with gastric cancer than those with inactive chronic gastritis. Conclusion. According to our analysis, there was no correlation between coinfection and polymorphisms in genes encoding IL-10 and IL-1RN. We conclude that various factors can be involved in the development of gastric diseases.

scholarly journals Genome-wide DNA methylation profiles altered by Helicobacter pylori in gastric mucosa and blood leukocyte DNA

Oncotarget ◽  
2016 ◽  
Vol 7 (24) ◽  
pp. 37132-37144 ◽  
Author(s):  
Yang Zhang ◽  
Xin-ran Zhang ◽  
Jong-lyul Park ◽  
Jong-hwan Kim ◽  
Lian Zhang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Genome Wide ◽  
Blood Leukocyte

scholarly journals Lectin binding patterns in normal, metaplastic, and neoplastic gastric mucosa.

1992 ◽  
Vol 40 (5) ◽  
pp. 681-687 ◽  
Author(s):  
T Narita ◽  
H Numao
Keyword(s):  
Gastric Mucosa ◽  
Lectin Binding ◽  
Type A ◽  
Blood Groups ◽  
Blood Type ◽  
Luminal Surface ◽  
Diffuse Type ◽  
Normal Gastric Mucosa ◽  
Significant Difference ◽  
Tissue Specimens

We investigated lectin binding patterns on tissue specimens of normal and metaplastic gastric surface mucosae, gastric adenomas, and intestinal and diffuse-type gastric carcinomas. Compared with normal gastric mucosa, metaplastic mucosa exhibited an increase of ConA binding and decreases of WGA, PNA, UEA-1, and DBA binding in the cytoplasm, and decreases of ConA, PNA, and UEA-1 binding at the luminal surface. Intestinal carcinomas were similar to metaplastic gastric surface mucosa in ConA, WGA, and UEA-1 binding in the cytoplasm, while diffuse-type carcinomas were similar to normal gastric mucosa in WGA and UEA-1 binding in the cytoplasm. Adenomas were similar to intestinal carcinomas in ConA and UEA-1 binding in the cytoplasm, but were different from intestinal carcinomas in Con A and UEA-1 binding at the luminal surface. For UEA-1, normal and metaplastic gastric surface mucosae did not show a significant difference between the blood type A, AB, B group and the O group. Intestinal and diffuse carcinomas and adenomas also did not show such a difference between the blood groups. For DBA, normal gastric surface mucosa showed a significant difference between the blood type B, O group and the A, AB group. Normal gastric mucosa of the blood type A, AB group was frequently positive for DBA binding in the cytoplasm and at the luminal surface. Metaplastic mucosa did not show a significant difference between the blood groups. Intestinal and diffuse-type carcinomas and adenomas also did not show a difference between the blood groups. DBA binding in the cytoplasm of intestinal carcinomas and adenomas was more frequently positive than that of normal and metaplastic mucosae, except for normal gastric mucosa of the blood type A, AB group. Compared with diffuse-type carcinomas, intestinal carcinomas were accompanied by a significant increase of ConA binding and decreases of WGA and PNA binding in the cytoplasm.

Sign in / Sign up

Export Citation Format

Share Document