scholarly journals Adenovirus vector-based prime-boost vaccination via heterologous routes induces cervicovaginal CD8+ T cell responses against HPV16 oncoproteins

2017 ◽  
Vol 142 (7) ◽  
pp. 1467-1479 ◽  
Author(s):  
Nicolas Çuburu ◽  
Selina Khan ◽  
Cynthia D. Thompson ◽  
Rina Kim ◽  
Jort Vellinga ◽  
...  
Keyword(s):  
T Cell ◽  
Adenovirus Vector ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Boost Vaccination

scholarly journals Heterologous Prime Boost Vaccination Induces Protective Melanoma-Specific CD8+ T Cell Responses

2020 ◽  
Vol 19 ◽  
pp. 179-187
Author(s):  
Sandra S. Ring ◽  
Michał Królik ◽  
Fabienne Hartmann ◽  
Erika Schmidt ◽  
Omar Hasan Ali ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Boost Vaccination

scholarly journals Longitudinal Requirement for CD4+T Cell Help for Adenovirus Vector–Elicited CD8+T Cell Responses

2014 ◽  
Vol 192 (11) ◽  
pp. 5214-5225 ◽  
Author(s):  
Nicholas M. Provine ◽  
Rafael A. Larocca ◽  
Pablo Penaloza-MacMaster ◽  
Erica N. Borducchi ◽  
Anna McNally ◽  
...  
Keyword(s):  
T Cell ◽  
Adenovirus Vector ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Cd4 T Cell Help ◽  
T Cell Help

Combined HDAC and BET inhibition to enhance cancer vaccine-elicited T-cell responses.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e14632-e14632
Author(s):  
Alexander Badamchi-Zadeh ◽  
Kelly Dare Moynihan ◽  
Nicholas M Provine ◽  
Rafael Larocca ◽  
Darrell J Irvine ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd8 T Cells ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Ductal Adenocarcinoma ◽  
Cell Responses ◽  
Boost Vaccination ◽  
Immunological Mechanisms ◽  
Ifn Γ

e14632 Background: The combined inhibition of histone deacetylases (HDAC) and the proteins of the bromo and extra terminal (BET) family have recently shown therapeutic efficacy against pancreatic ductal adenocarcinoma, melanoma and lymphoma cancers in murine studies. However, in these studies the role of the immune system in therapeutically controlling these cancers was not explored. Methods: We sought to investigate the effect of the HDAC inhibitor romidepsin (RMD) and the BET inhibitor I-BET151, both singly and in combination, on vaccine elicited immune responses. C57Bl/6 mice were immunized with differing vaccines (Adenoviral, protein) in prime-boost regimens, under treatment with RMD, I-BET151, or RMD+I-BET151. Results: The combination RMD+I-BET151, administered during Adenoviral prime-boost vaccination, resulted in the significant increase in the frequency and number of antigen-specific CD8 T cells. RMD+I-BET151 treatment affected vaccine-elicited secondary T cell responses, significantly increasing the frequency of IFN-γ+ splenic CD8 T cells and maintaining their dual IFN-γ+TNFa+ polyfunctionality. These CD8 T cells maintained their protective ability against Listeria monocytogenes, and protected against B16-OVA challenge. The significant augmentation of vaccine elicited CD8 T cell responses under RMD+I-BET151 treatment was additionally observed following protein (OVA+CpG) prime-boost vaccination, resulting in greater protection against B16-OVA challenge and enhanced survival. T-regulatory cell (FoxP3+CD4+) frequency and total CD4 and CD8 cell numbers remained unaltered following RMD+I-BET151 treatment. Conclusions: Combined HDAC and BET inhibition resulted in greater vaccine-elicited CD8 T cell responses following immunization by multiple vaccine platforms, and enhanced protection against B16-OVA challenges. We are currently assessing immunological mechanisms of action for this combined HDAC and BET inhibition.

scholarly journals TLR1/2 Activation during Heterologous Prime-Boost Vaccination (DNA-MVA) Enhances CD8+ T Cell Responses Providing Protection against Leishmania (Viannia)

2011 ◽  
Vol 5 (6) ◽  
pp. e1204 ◽  
Author(s):  
Asha Jayakumar ◽  
Tiago M. Castilho ◽  
Esther Park ◽  
Karen Goldsmith-Pestana ◽  
Jenefer M. Blackwell ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Boost Vaccination

scholarly journals CD4 and CD8 T Cell Responses to the M. tuberculosis Ag85B-TB10.4 Promoted by Adjuvanted Subunit, Adenovector or Heterologous Prime Boost Vaccination

PLoS ONE ◽  
2009 ◽  
Vol 4 (4) ◽  
pp. e5139 ◽  
Author(s):  
Tara Elvang ◽  
Jan P. Christensen ◽  
Rolf Billeskov ◽  
Truc Thi Kim Thanh Hoang ◽  
Peter Holst ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Boost Vaccination

Type-I IFN signaling is required for the induction of antigen-specific CD8+ T cell responses by adenovirus vector vaccine in the gut-mucosa

2012 ◽  
Vol 425 (1) ◽  
pp. 89-93 ◽  
Author(s):  
Masaki Shoji ◽  
Masashi Tachibana ◽  
Kazufumi Katayama ◽  
Kyoko Tomita ◽  
Sayaka Tsuzuki ◽  
...  
Keyword(s):  
T Cell ◽  
Adenovirus Vector ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Type I ◽  
Type I Ifn ◽  
Vector Vaccine ◽  
Cell Responses ◽  
Gut Mucosa
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