scholarly journals Advanced paternal age and childhood cancer in offspring: A nationwide register-based cohort study

2017 ◽  
Vol 140 (11) ◽  
pp. 2461-2472 ◽  
Author(s):  
Stine Kjaer Urhoj ◽  
Ole Raaschou-Nielsen ◽  
Anne Vinkel Hansen ◽  
Laust Hvas Mortensen ◽  
Per Kragh Andersen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Childhood Cancer ◽  
Paternal Age ◽  
Advanced Paternal Age ◽  
Cancer In Offspring

scholarly journals Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ligia Rios ◽  
Liliana Vásquez ◽  
Mónica Oscanoa ◽  
Iván Maza ◽  
Jenny Gerónimo
Keyword(s):  
Germ Cell ◽  
Childhood Cancer ◽  
Solid Tumors ◽  
Case Control Study ◽  
Germ Cell Tumors ◽  
Case Control ◽  
Paternal Age ◽  
Parental Age ◽  
Advanced Paternal Age ◽  
Control Study

Background. The causes of childhood cancer are not well known, but the advanced age of the parents has been suggested as a risk factor for childhood cancer in several observational studies. In this study, we examine a possible link between parental age and childhood solid tumors. Methods. We conducted a hospital-based case-control study (310 cases and 620 controls, matched by age and gender) at Rebagliati Hospital, Lima, Peru. Odd ratio was used to compare categories of advancing maternal and paternal age with and without adjusting for possible confounding factors were calculated. Results. The risk of childhood retinoblastoma was significantly higher among children of mothers aged> 35 years (adjusted OR 1.21; 95% CI, 1.09-6.08) and fathers aged> 35 years (OR 1.17; 1.01-16.33). A significant trend with increasing mother's age (p = 0.037) and father's age (p = 0.005) was found. There were more risks to development of non-Hodgkin's lymphoma (p = 0.047) and gonadal germ cell tumors (p = 0.04) for advanced paternal age. There was a strong protective effect of increasing parity on risk of solid tumors in children (p=0.0015). Conclusion. Our results suggest that advanced parental age is associated with the risk for the development of retinoblastoma. Advanced paternal age increases the risk of non-Hodgkin lymphoma and gonadal germ cell tumor. The higher the order of birth of the children, the less the chance of developing any neoplasm.

scholarly journals Advanced paternal age and mortality of offspring under 5 years of age: a register-based cohort study

2013 ◽  
Vol 29 (2) ◽  
pp. 343-350 ◽  
Author(s):  
S. K. Urhoj ◽  
L. N. Jespersen ◽  
M. Nissen ◽  
L. H. Mortensen ◽  
A.- M. Nybo Andersen
Keyword(s):  
Cohort Study ◽  
Paternal Age ◽  
Advanced Paternal Age

scholarly journals Advanced Paternal Age and Risk of Fetal Death: A Cohort Study

2004 ◽  
Vol 160 (12) ◽  
pp. 1214-1222 ◽  
Author(s):  
A.-M. Nybo Andersen ◽  
K. D. Hansen ◽  
P. K. Andersen ◽  
G. Davey Smith
Keyword(s):  
Cohort Study ◽  
Fetal Death ◽  
Paternal Age ◽  
Advanced Paternal Age

scholarly journals Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark

2017 ◽  
Vol 32 (3) ◽  
pp. 227-234 ◽  
Author(s):  
Stine Kjaer Urhoj ◽  
Per Kragh Andersen ◽  
Laust Hvas Mortensen ◽  
George Davey Smith ◽  
Anne-Marie Nybo Andersen
Keyword(s):  
Cohort Study ◽  
Paternal Age ◽  
Stillbirth Rate ◽  
Advanced Paternal Age

scholarly journals O5-6.3 Advanced paternal age and risk of death before the age of 5 years: a register-based cohort study

2011 ◽  
Vol 65 (Suppl 1) ◽  
pp. A57-A57
Author(s):  
A. M. N. Andersen ◽  
L. N. Jespersen ◽  
M. Nissen ◽  
L. H. Mortensen
Keyword(s):  
Cohort Study ◽  
Paternal Age ◽  
Advanced Paternal Age ◽  
Risk Of Death

Re: Advanced Paternal Age and Mortality of Offspring Under Five Years of Age: A Register-based Cohort Study

2014 ◽  
Vol 65 (6) ◽  
pp. 1222-1223
Author(s):  
Jason R. Kovac ◽  
Ranjith Ramasamy ◽  
James M. Dupree ◽  
Larry I. Lipshultz
Keyword(s):  
Cohort Study ◽  
Paternal Age ◽  
Advanced Paternal Age ◽  
Under Five

scholarly journals Advanced paternal age and risk of cancer in offspring

Aging ◽  
2020 ◽  
Author(s):  
Yangyang Sun ◽  
Xu Li ◽  
Wei Jiang ◽  
Yuanming Fan ◽  
Qiong Ouyang ◽  
...  
Keyword(s):  
Paternal Age ◽  
Advanced Paternal Age ◽  
Risk Of Cancer ◽  
Cancer In Offspring

scholarly journals P9 A study to investigate the impact of the COVID-19 pandemic on paediatric cancer patients: an international, multicentre, observational cohort study (COVIDPaedsCancer)

BJS Open ◽  
2021 ◽  
Vol 5 (Supplement_1) ◽  
Author(s):  
◽  
Soham Bandyopadhyay
Keyword(s):  
Cohort Study ◽  
Cancer Treatment ◽  
Childhood Cancer ◽  
Multivariate Logistic Regression Analysis ◽  
Global Health Research ◽  
Cancer Outcomes ◽  
Paediatric Cancer ◽  
Cancer Management ◽  
Anti Cancer ◽  
The Impact

Abstract Introduction Childhood cancers are a leading cause of non-communicable disease deaths for paediatric patients around the world. The COVID-19 pandemic may have impacted on global children’s cancer services, which can have consequences for childhood cancer outcomes. The Global Health Research Group on Children’s Non-Communicable Diseases (Global Children’s NCDs) is currently undertaking the first international study to determine the variation in paediatric cancer management during the COVID-19 pandemic, and the short to medium term impacts on childhood cancer outcomes. Methods and analysis This is a multicentre, international, cohort study that will use routinely collected hospital data in a de-identified and anonymised form. Patients will be recruited consecutively into the study, with a 12 -month follow-up period. Patients will be included if they are below the age of 18 years and undergoing anti-cancer treatment for the following cancers: Acute lymphoblastic leukaemia, Burkitt’s Lymphoma, Hodgkin's lymphoma, Wilms Tumour, Sarcoma, Retinoblastoma, Gliomas, Medulloblastomas and Neuroblastomas. Patients must be newly presented or be undergoing active anti-cancer treatment from the 12th March 2020 to the 12th December 2020. The primary objective of the study is to determine 30- and 90-day all-cause mortality rates. This study will examine the factors that influenced these outcomes. Chi-squared analysis will be used to compare mortality between low and middle-income countries and high-income countries. Multilevel, multivariate logistic regression analysis will be undertaken to identify patient-level and hospital-level factors affecting outcomes with adjustment for confounding factors. Ethics and dissemination At the host centre, this study was deemed to be exempt from ethical committee approval due to the use of anonymised registry data. At other centres, participating collaborators have gained local approvals in accordance with their institutional ethical regulations. Collaborators will be encouraged to present the results locally, nationally, and internationally. The results will be submitted for publication in a peer reviewed journal.

Sign in / Sign up

Export Citation Format

Share Document