scholarly journals Genetic variants in the integrin signaling pathway genes predict cutaneous melanoma survival

2016 ◽  
Vol 140 (6) ◽  
pp. 1270-1279 ◽  
Author(s):  
Hongyu Li ◽  
Yanru Wang ◽  
Hongliang Liu ◽  
Qiong Shi ◽  
Yinghui Xu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cutaneous Melanoma ◽  
Genetic Variants ◽  
Integrin Signaling

scholarly journals Genetic variants in the calcium signaling pathway genes are associated with cutaneous melanoma-specific survival

2018 ◽  
Vol 40 (2) ◽  
pp. 279-288 ◽  
Author(s):  
Xiaomeng Wang ◽  
Hongliang Liu ◽  
Yinghui Xu ◽  
Jichun Xie ◽  
Dakai Zhu ◽  
...  
Keyword(s):  
Calcium Signaling ◽  
Signaling Pathway ◽  
Cutaneous Melanoma ◽  
Genetic Variants ◽  
Calcium Signaling Pathway

scholarly journals Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival

Oncotarget ◽  
2017 ◽  
Vol 8 (43) ◽  
pp. 74595-74606 ◽  
Author(s):  
Hong Li ◽  
Yanru Wang ◽  
Hongliang Liu ◽  
Qiong Shi ◽  
Hongyu Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cutaneous Melanoma ◽  
Genetic Variants ◽  
Pdgf Signaling

scholarly journals DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Guillaume B. Cardin ◽  
Monique Bernard ◽  
Francis Rodier ◽  
Apostolos Christopoulos
Keyword(s):  
Breast Carcinoma ◽  
Signaling Pathway ◽  
Prognostic Value ◽  
Colorectal Adenocarcinoma ◽  
Prostate Adenocarcinoma ◽  
Small Cell ◽  
Invasive Breast Carcinoma ◽  
Integrin Signaling ◽  
Small Cell Lung ◽  
And Function

AbstractGermline single nucleotide polymorphisms in the promoter region of the DCBLD1 gene are associated with non-smoking cases of both non-small cell lung carcinoma (NSCLC) and human papillomavirus-negative head and neck cancer. However the clinical relevance and function of DCBLD1 remain unclear. This multicenter retrospective study was designed to evaluate the prognostic value and function of DCBLD1 in the four main solid cancers: NSCLC, invasive breast carcinoma, colorectal adenocarcinoma and prostate adenocarcinoma. We included the following cohorts: GSE81089 NSCLC, METABRIC invasive breast carcinoma, GSE14333 colorectal adenocarcinoma, GSE70770 prostate adenocarcinoma and The Cancer Genome Atlas (TCGA) Firehose Legacy cohorts of all four cancers. DCBLD1 gene expression was associated with a worse overall survival in multivariate analyses for both NSCLC cohorts (TCGA: P = 0.03 and GSE81089: P = 0.04) and both invasive breast carcinoma cohorts (TCGA: P = 0.02 and METABRIC: P < 0.001). Patients with high DCBLD1 expression showed an upregulation of the integrin signaling pathway in comparison to those with low DCBLD1 expression in the TCGA NSCLC cohort (FDR = 5.16 × 10–14) and TCGA invasive breast carcinoma cohort (FDR = 1.94 × 10–05).

scholarly journals Genetic variants of SDCCAG8 and MAGI2 in mitosis‐related pathway genes are independent predictors of cutaneous melanoma‐specific survival

2021 ◽  
Author(s):  
Yuanmin He ◽  
Hongliang Liu ◽  
Sheng Luo ◽  
Christopher I. Amos ◽  
Jeffrey E. Lee ◽  
...  
Keyword(s):  
Cutaneous Melanoma ◽  
Genetic Variants ◽  
Related Pathway

scholarly journals Possible involvement of integrin signaling pathway in the process of recovery from restraint stress in rats

2007 ◽  
Vol 23 (4) ◽  
pp. 229-235 ◽  
Author(s):  
Yu-Zhen Gao ◽  
Shi-Yu Guo ◽  
Qi-Zhang Yin ◽  
Xiang-Qin Cui ◽  
Tadashi Hisamitsu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Restraint Stress ◽  
Integrin Signaling

scholarly journals Genetic variants of the peroxisome proliferator‐activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer

2020 ◽  
Vol 59 (8) ◽  
pp. 930-939
Author(s):  
Xiaowen Liu ◽  
Danwen Qian ◽  
Hongliang Liu ◽  
James L. Abbruzzese ◽  
Sheng Luo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathway ◽  
Genetic Variants ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ppar Signaling

Integrin signaling's potential for mediating gene expression in hypertrophying skeletal muscle

2000 ◽  
Vol 88 (1) ◽  
pp. 337-343 ◽  
Author(s):  
James A. Carson ◽  
Lei Wei
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Signaling Pathway ◽  
Mechanical Load ◽  
Integrin Signaling ◽  
Mechanical Forces ◽  
Growth Factor Signaling ◽  
Muscle Gene

Overloaded skeletal muscle undergoes dramatic shifts in gene expression, which alter both the phenotype and mass. Molecular biology techniques employing both in vivo and in vitro hypertrophy models have demonstrated that mechanical forces can alter skeletal muscle gene regulation. This review's purpose is to support integrin-mediated signaling as a candidate for mechanical load-induced hypertrophy. Research quantifying components of the integrin-signaling pathway in overloaded skeletal muscle have been integrated with knowledge regarding integrins role during development and cardiac hypertrophy, with the hope of demonstrating the pathway's importance. The role of integrin signaling as an integrator of mechanical forces and growth factor signaling during hypertrophy is discussed. Specific components of integrin signaling, including focal adhesion kinase and low-molecular-weight GTPase Rho are mentioned as downstream targets of this signaling pathway. There is a need for additional mechanistic studies capable of providing a stronger linkage between integrin-mediated signaling and skeletal muscle hypertrophy; however, there appears to be abundant justification for this type of research.

Abstract 4843: Genetic variants in Notch signaling pathway and ovarian cancer.

2013 ◽  
Author(s):  
Enping Xu ◽  
Karen H. Lu ◽  
Michelle AT Hildebrandt ◽  
Maosheng Huang ◽  
Xifeng Wu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Genetic Variants ◽  
Notch Signaling Pathway
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