scholarly journals Palliative resection of the primary tumor is associated with improved overall survival in incurable stage IV colorectal cancer: A nationwide population-based propensity-score adjusted study in the Netherlands

2016 ◽  
Vol 139 (9) ◽  
pp. 2082-2094 ◽  
Author(s):  
Jorine 't Lam-Boer ◽  
Lydia G. Van der Geest ◽  
Cees Verhoef ◽  
Marloes E. Elferink ◽  
Miriam Koopman ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Propensity Score ◽  
The Netherlands ◽  
Primary Tumor ◽  
Stage Iv ◽  
Population Based ◽  
Palliative Resection ◽  
Stage Iv Colorectal Cancer

Laparoscopic surgery for palliative resection of the primary tumor in incurable stage IV colorectal cancer

2012 ◽  
Vol 26 (11) ◽  
pp. 3201-3206 ◽  
Author(s):  
Hideaki Nishigori ◽  
Masaaki Ito ◽  
Yuji Nishizawa ◽  
Atsushi Kohyama ◽  
Takamaru Koda ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Laparoscopic Surgery ◽  
Primary Tumor ◽  
Stage Iv ◽  
Palliative Resection ◽  
Stage Iv Colorectal Cancer

The Role of Palliative Resection for Asymptomatic Primary Tumor in Patients With Unresectable Stage IV Colorectal Cancer

2014 ◽  
Vol 57 (9) ◽  
pp. 1049-1058 ◽  
Author(s):  
Jung-A Yun ◽  
Jung Wook Huh ◽  
Yoon Ah Park ◽  
Yong Beom Cho ◽  
Seong Hyeon Yun ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Primary Tumor ◽  
Stage Iv ◽  
Palliative Resection ◽  
Stage Iv Colorectal Cancer ◽  
Unresectable Stage

Survival impact of surgical resection of primary tumor in patients with stage IV colorectal cancer: Results from a large population-based cohort study

Cancer ◽  
2013 ◽  
Vol 120 (5) ◽  
pp. 683-691 ◽  
Author(s):  
Shahid Ahmed ◽  
Anne Leis ◽  
Anthony Fields ◽  
Selliah Chandra-Kanthan ◽  
Kamal Haider ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cohort Study ◽  
Surgical Resection ◽  
Primary Tumor ◽  
Large Population ◽  
Stage Iv ◽  
Population Based ◽  
Stage Iv Colorectal Cancer

Liver-directed therapies for colorectal cancer liver metastasis (CLRM): A Surveillance, Epidemiology, and End Results (SEER)-Medicare analysis.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 577-577 ◽  
Author(s):  
Muhammad Shaalan Beg ◽  
Faisal Adhami ◽  
Lei Xuan ◽  
Joseph Hodges ◽  
Jeffery Meyer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Transarterial Embolization ◽  
Stage Iv ◽  
National Sample ◽  
Population Based ◽  
Secondary Malignancy ◽  
Prospective Clinical Study ◽  
Stage Iv Colorectal Cancer ◽  
The Impact

577 Background: Oligometastatic CLRM comprises a distinct subset of stage IV colorectal cancer. Liver directed therapies (LDT) including surgery, ablation, radiation, and transarterial chemotherapy/embolization have been shown to improve cancer outcomes in smaller series. We sought to evaluate utilization of LDT and their impact on survival in patients with CLRM in a population-based database. Methods: We analyzed linked SEER-Medicare data. Eligible patients were ≥ 66 years, diagnosed between 1992-2009, carry a code for secondary malignancy of the liver (ICD-9 197.7) and survived ≥ 30 days after diagnosis. LDT (yes vs. no) were defined by ICD-9 and CPT codes of surgery (hepatectomy), ablation (e.g. radiofrequency and cryoablation), radiation (e.g., stereotactic surgery and brachytherapy), and transarterial/embolization (e.g., radioembolization). Treatment and non-treatment groups were matched using a propensity score comprised of a comprehensive set of patient and tumor characteristics including: age, sex, race, marital status, Medicaid status, and tumor histology, grade, and location. Cox Proportional Hazard models were used to compare the impact of the LDT on overall survival among propensity-matched pairs of treated and untreated patients. Results: LDT were performed in 12.7% (n = 1,793) of all 14,150 patients. There were 13.7% of patients over 85 years. Females were 52.1% and 83 % White. Off all, 5.4% had surgery, 3.9% had ablation, 4.6% had radiation, and 1.6% had transarterial chemotherapy/embolization. Unadjusted 5 year overall-survival (OS) was 26.9% for those underdoing LDT vs. 7.5% who did not (HR = 0.44, (CI 0.41,0.46)). Cox modeling demonstrated a survival benefit for each LDT with HR of 0.36 (0.33,0.39) for surgery, 0.35 (0.32,0.39) for ablation, 0.78 (0.72, 0.85) for radiation and 0.42 (0.36,0.49) for transarterial/embolization. Conclusions: While use of LDT for CLRM in this national sample of Medicare patients were low, those who received treatment had markedly improved survival compared to matched patients who did not. Surgery and ablation were the most effective therapies. These findings require evaluation in a prospective clinical study.

Use of Surgery Among Elderly Patients With Stage IV Colorectal Cancer

2004 ◽  
Vol 22 (17) ◽  
pp. 3475-3484 ◽  
Author(s):  
Larissa K.F. Temple ◽  
Lillian Hsieh ◽  
W. Douglas Wong ◽  
Leonard Saltz ◽  
Deborah Schrag
Keyword(s):  
Colorectal Cancer ◽  
Primary Tumor ◽  
Postoperative Mortality ◽  
Stage Iv ◽  
Population Based ◽  
Treatment Modalities ◽  
Medicare Beneficiaries ◽  
Stage Iv Colorectal Cancer ◽  
Lower Socioeconomic

Purpose The role of surgery to remove the primary tumor among patients with stage IV colorectal cancer (CRC) is controversial. The purpose of this study was to evaluate surgical practice patterns for patients ≥ 65 years of age with stage IV CRC in a US population-based cohort. Patients and Methods We used the Surveillance, Epidemiology, and End Results-Medicare–linked database to evaluate the patterns of cancer treatment for 9,011 Medicare beneficiaries presenting with stage IV CRC from 1991 to 1999. Patients were categorized according to whether they had primary–cancer-directed surgery (CDS) or no CDS within 4 months of diagnosis. The use of other treatment modalities, including metastasectomy, chemotherapy, and radiation, was evaluated in relationship to whether patients belonged to the CDS or no CDS group. Results Seventy-two percent (6,469 of 9,011) of patients received CDS, and their 30-day postoperative mortality was 10%. Patients with left-sided or rectal lesions, patients older than age 75 years, blacks, and those of lower socioeconomic status were less likely to undergo CDS; but even among those older than age 75, the CDS rate was 69% (3,378 of 4,909). In contrast, chemotherapy use was less common (47% for patients who had CDS and 31% for those who did not). Metastasectomy was rare; only 3.9% of patients underwent these operations at any point from diagnosis to death. Conclusion Palliative resection of the primary tumor is often performed for elderly US patients with stage IV colorectal cancer. This practice pattern merits re-evaluation, given the improvement in the efficacy of systemic chemotherapy.

Low Nutritional Prognostic Index Correlates with Poor Survival in Patients with Stage IV Colorectal Cancer Following Palliative Resection of the Primary Tumor

2013 ◽  
Vol 38 (5) ◽  
pp. 1217-1222 ◽  
Author(s):  
Kiyoshi Maeda ◽  
Masatsune Shibutani ◽  
Hiroshi Otani ◽  
Hisashi Nagahara ◽  
Kenji Sugano ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Primary Tumor ◽  
Prognostic Index ◽  
Stage Iv ◽  
Palliative Resection ◽  
Poor Survival ◽  
Stage Iv Colorectal Cancer
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