scholarly journals Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels

2016 ◽  
Vol 139 (7) ◽  
pp. 1520-1533 ◽  
Author(s):  
Carolina Bonilla ◽  
Sarah J. Lewis ◽  
Mari-Anne Rowlands ◽  
Tom R. Gaunt ◽  
George Davey Smith ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factors ◽  
Genetic Variants ◽  
Binding Proteins ◽  
Mendelian Randomization ◽  
Circulating Levels ◽  
Insulin Like Growth Factors

scholarly journals The Role of the Insulin-Like Growth Factors and Their Binding Proteins in Glucose Homeostasis

2003 ◽  
Vol 4 (4) ◽  
pp. 213-224 ◽  
Author(s):  
Liam J. Murphy
Keyword(s):  
Growth Factors ◽  
Glucose Homeostasis ◽  
Binding Proteins ◽  
Biological Fluids ◽  
Short Term ◽  
High Affinity ◽  
Igf I ◽  
Igfbp 3 ◽  
Insulin Like Growth Factors

The insulin like growth factors (IGF-I and -II) are structurally and functionally related to insulin. While insulin is a key regulator of glucose homeostasis over the short term, emerging evidence suggests that the IGFs are involved in the longer term glucose homeostasis, possibly by modulating insulin sensitivity. Unlike insulin, the IGFs are present in most biological fluids as complexes with high affinity binding proteins, the insulin-like growth factor binding proteins (IGFBPs). The IGFBPs regulate the bioavailability of the IGFs. Of the six IGFBPs identified there is evidence from studies in transgenic mice that both IGFBP-1 and IGFBP-3 may have a role in glucose regulation.

scholarly journals PROSTATE CANCER AND DIABETES LINK: ROLE OF INSULIN AND INSULIN LIKE GROWTH FACTORS

2019 ◽  
Vol 6 (2) ◽  
pp. 147-151
Author(s):  
Afreen Khan ◽  
Anu Chandra ◽  
Abbas Ali Mahdi ◽  
S.N. Sankhwar
Keyword(s):  
Prostate Cancer ◽  
Growth Factors ◽  
Insulin Like Growth Factors
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