scholarly journals Polymorphisms in DNA repair genes, traffic-related polycyclic aromatic hydrocarbon exposure and breast cancer incidence

2016 ◽  
Vol 139 (2) ◽  
pp. 310-321 ◽  
Author(s):  
Irina Mordukhovich ◽  
Jan Beyea ◽  
Amy H. Herring ◽  
Maureen Hatch ◽  
Steven D. Stellman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Cancer Incidence ◽  
Breast Cancer Incidence ◽  
Dna Repair Genes ◽  
Polycyclic Aromatic ◽  
Repair Genes

Truncating variants in DNA-repair genes and their effect on AAO of hereditary breast cancer

2018 ◽  
Author(s):  
I Sepahi ◽  
U Faust ◽  
M Sturm ◽  
K Bosse ◽  
M Kehrer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Hereditary Breast Cancer ◽  
Dna Repair Genes ◽  
Repair Genes

Polymorphisms in DNA repair genes, ionizing radiation exposure and risk of breast cancer in U.S. Radiologic technologists

2008 ◽  
Vol 122 (1) ◽  
pp. 177-182 ◽  
Author(s):  
Parveen Bhatti ◽  
Jeffery P. Struewing ◽  
Bruce H. Alexander ◽  
Michael Hauptmann ◽  
Laura Bowen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Ionizing Radiation ◽  
Radiation Exposure ◽  
Dna Repair Genes ◽  
Radiologic Technologists ◽  
Ionizing Radiation Exposure ◽  
Repair Genes

scholarly journals A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells

2020 ◽  
Author(s):  
Larisa M Gearhart-Serna ◽  
John B Davis ◽  
Mohit Kumar Jolly ◽  
Nishad Jayasundara ◽  
Scott J Sauer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Complex Mixture ◽  
Environmental Chemicals ◽  
Er Positive ◽  
Polycyclic Aromatic

Abstract Emerging evidence suggests the role of environmental chemicals, in particular endocrine-disrupting chemicals (EDCs), in progression of breast cancer and treatment resistance, which can impact survival outcomes. However, most research tends to focus on tumor etiology and the effect of single chemicals, offering little insight into the effects of realistic complex mixture exposures on tumor progression. Herein, we investigated the effect of a polycyclic aromatic hydrocarbon (PAH)-enriched EDC mixture in a panel of normal and breast cancer cells and in a tumor organoid model. Cells or organoids in culture were treated with EDC mixture at doses estimated from US adult intake of the top four PAH compounds within the mixture from the National Health and Nutrition Examination Survey database. We demonstrate that low-dose PAH mixture (6, 30 and 300 nM) increased aryl hydrocarbon receptor (AhR) expression and CYP activity in estrogen receptor (ER) positive but not normal mammary or ER-negative breast cancer cells, and that upregulated AhR signaling corresponded with increased cell proliferation and expression of antiapoptotic and antioxidant proteins XIAP and SOD1. We employed a mathematical model to validate PAH-mediated increases in AhR and XIAP expression in the MCF-7 ER-positive cell line. Furthermore, the PAH mixture caused significant growth increases in ER-negative breast cancer cell derived 3D tumor organoids, providing further evidence for the role of a natural-derived PAH mixture in enhancing a tumor proliferative phenotype. Together, our integrated cell signaling, computational and phenotype analysis reveals the underlying mechanisms of EDC mixtures in breast cancer progression and survival.

scholarly journals Polycyclic Aromatic Hydrocarbon–DNA Adducts and Breast Cancer: A Pooled Analysis

2004 ◽  
Vol 59 (12) ◽  
pp. 640-649 ◽  
Author(s):  
Marilie D. Gammon ◽  
Sharon K. Sagiv ◽  
Sybil M. Eng ◽  
Sumitra Shantakumar ◽  
Mia M. Gaudet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Dna Adducts ◽  
Pooled Analysis ◽  
Polycyclic Aromatic
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