scholarly journals The serrated neoplasia pathway of colorectal tumors: Identification ofMUC5AChypomethylation as an early marker of polyps with malignant potential

2015 ◽  
Vol 138 (6) ◽  
pp. 1472-1481 ◽  
Author(s):  
Florence Renaud ◽  
Christophe Mariette ◽  
Audrey Vincent ◽  
Agnès Wacrenier ◽  
Vincent Maunoury ◽  
...  
Keyword(s):  
Malignant Potential ◽  
Colorectal Tumors ◽  
Early Marker ◽  
Serrated Neoplasia Pathway

Analysis of the depressed area of small flat and depressed-type colorectal tumors as a marker of malignant potential

1997 ◽  
Vol 45 (5) ◽  
pp. 412-414 ◽  
Author(s):  
Takeshi Terai ◽  
Hiroto Miwa ◽  
Yasushi Imai ◽  
Ryo Wada ◽  
Tatsuo Ogihara ◽  
...  
Keyword(s):  
Malignant Potential ◽  
Colorectal Tumors ◽  
Depressed Type

scholarly journals Minimal Barriers to Invasion During Human Colorectal Tumor Growth

2019 ◽  
Author(s):  
Marc D. Ryser ◽  
Diego Mallo ◽  
Allison Hall ◽  
Timothy Hardman ◽  
Lorraine M. King ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Growth ◽  
Clonal Evolution ◽  
Malignant Potential ◽  
Colorectal Tumor ◽  
Cancer Growth ◽  
Colorectal Tumors ◽  
Small Tumor ◽  
Phenotypic Information

ABSTRACTIntra-tumoral heterogeneity (ITH) could represent clonal evolution where subclones with greater fitness confer more malignant phenotypes and invasion constitutes an evolutionary bottleneck. Alternatively, ITH could represent branching evolution with invasion of multiple subclones. The two models respectively predict a hierarchy of subclones arranged by phenotype, or multiple subclones with shared phenotypes. We delineated these modes of invasion by merging ancestral, topographic, and phenotypic information from 12 human colorectal tumors (11 carcinomas, 1 adenoma) obtained through saturation microdissection of 325 small tumor regions. The majority of subclones (29/46, 60%) shared superficial and invasive phenotypes. Of 11 carcinomas, 9 showed evidence of multiclonal invasion, and invasive and metastatic subclones arose early along the ancestral trees. Early multiclonal invasion in the majority of these tumors indicates the expansion of co-evolving subclones with similar malignant potential in absence of late bottlenecks, and suggests that barriers to invasion are minimal during colorectal cancer growth.

scholarly journals Nut and peanut butter intake and the risk of colorectal cancer and its anatomical and molecular subtypes: the Netherlands Cohort Study

2020 ◽  
Vol 41 (10) ◽  
pp. 1368-1384
Author(s):  
Lisette Nieuwenhuis ◽  
Colinda C J M Simons ◽  
Matty P Weijenberg ◽  
Piet A van den Brandt
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Cohort Study ◽  
Cancer Risk ◽  
Peanut Butter ◽  
Colorectal Tumors ◽  
Increased Risk ◽  
Nut Intake ◽  
Serrated Neoplasia Pathway

Abstract Nut intake has been associated with reduced total cancer-related mortality, but evidence for colorectal cancer (CRC) risk is inconclusive. We investigated the associations between nut and peanut butter intake and anatomical CRC subtypes. To account for molecular heterogeneity, associations between nut and peanut butter intake and colorectal tumors harboring APC, KRAS or BRAF mutations, p53 overexpression or microsatellite instability were examined in secondary analyses. In the Netherlands Cohort Study (n = 120 852), lifestyle habits were measured with a questionnaire in 1986. After 20.3 years follow-up, 3567 CRC cases were included in case–cohort analyses. For the analyses of molecular CRC subtypes, 574 cases were included after 7.3 years follow-up. In categorical analyses, total nut intake was not significantly associated with CRC [HR (95% CI) 10+ g/day versus non-consumers = 0.94(0.78–1.15) in men; 0.96(0.75–1.22) in women]. In restricted cubic spline analyses, significant non-linear inverse associations with rectal cancer were observed for total nut, peanut and peanut butter intake in women, and borderline significant non-linear inverse associations for total nut and peanut intake in men. Regarding the molecular CRC subtypes, peanut butter intake was significantly associated with an increased risk of colorectal tumors that did not develop through the serrated neoplasia pathway in men [HR (95% CI) per 5 g/day increment = 1.22(1.07–1.38)]. Nut and peanut butter intake are non-linearly inversely associated with rectal cancer risk in women. In men, nut intake is borderline significantly non-linearly associated with a reduced rectal cancer risk. Peanut butter is associated with an increased risk of colorectal tumors that do not develop through the serrated neoplasia pathway in men.

Ultrastructure of Cryptorchidism and Seminoma

1981 ◽  
Vol 39 ◽  
pp. 540-541
Author(s):  
Shirley Siew ◽  
Susan C. James
Keyword(s):  
Malignant Tumors ◽  
Frozen Section ◽  
Malignant Potential ◽  
Genetic Influences ◽  
Endocrine Gland ◽  
Medial Aspect ◽  
Left Testis ◽  
Bilateral Orchiectomy

Testicular maldescent is the most common endocrine gland abnormality, as 2.7% of mature neonates are cryptorchid. The significant complications are that there is a disturbance of normal maturation which results in diminished fertility and there is an increase in the malignant potential which is 35 times greater in the undescended than the descended testis. It is considered that genetic influences may be of etiological importance and recurrence has been described in some families. It is of interest, that the case reported here has 2 siblings who have also presented with cryptorchidism and malignant tumors.The propositus is 14 years old. He is well developed (described by some as obese) and shows normal secondary male characteristics except for an immature scrotum. Laparotomy showed both testes to be intraabdominal. A hard nodule (0.5cm) was palpated on the medial aspect of the left testis. Frozen section showed the presence of seminoma and bilateral orchiectomy was performed.

Serum and tissue PIVKA-II expression reflect the biological malignant potential of small hepatocellular carcinoma

2001 ◽  
Vol 120 (5) ◽  
pp. A558-A558
Author(s):  
M TAMANO ◽  
K KOJIMA ◽  
M OGUMA ◽  
M LIJIMA ◽  
T MUROHISA ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Malignant Potential ◽  
Small Hepatocellular Carcinoma

604: Polyoma Virus Infection as an Early Marker for Bladder Transitional Cell Carcinoma

2005 ◽  
Vol 173 (4S) ◽  
pp. 165-165
Author(s):  
Paolo Gontero ◽  
Elisabetta Omodeo-Zorini ◽  
Paola Cacciotti ◽  
Filippo Sogni ◽  
Ervin Kocjancic ◽  
...  
Keyword(s):  
Virus Infection ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Transitional Cell ◽  
Polyoma Virus ◽  
Bladder Transitional Cell Carcinoma ◽  
Early Marker

Castleman's Disease Masquerading as Sigmoid Colon Tumor and Hodgkin Lymphoma

Swiss Surgery ◽  
2002 ◽  
Vol 8 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Altinli ◽  
Pekmezci ◽  
Balkan ◽  
Somay ◽  
M. Akif Buyukbese ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Sigmoid Colon ◽  
Castleman’S Disease ◽  
Malignant Potential ◽  
Colon Tumor ◽  
Rare Entity ◽  
Castleman's Disease ◽  
Mediastinal Lymph Nodes ◽  
Histologic Types

Castleman's disease is a benign lymphoid neoplasm first reported as hyperplasia of mediastinal lymph nodes. Some authors referred to the lesions as isolated tumors, described as a variant of Hodgkin's disease with a possibility of a malignant potential and others proposed that the lymphoid masses were of a hamartomatous nature. Three histologic variants and two clinical types of the disease have been described. The disease may occur in almost any area in which lymph nodes are normally found. The most common locations are thorax (63%), abdomen (11%) and axilla (4%). We report two separate histologic types of Castleman's disease which were rare in the literature, mimicking sigmoid colon tumor and Hodgkin lymphoma. The diagnostic and therapeutic aspects of this rare entity is discussed.

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