scholarly journals Phylogenetic analysis of multiple FISH markers in oral tongue squamous cell carcinoma suggests that a diverse distribution of copy number changes is associated with poor prognosis

2015 ◽  
Vol 138 (1) ◽  
pp. 98-109 ◽  
Author(s):  
Darawalee Wangsa ◽  
Salim Akhter Chowdhury ◽  
Michael Ryott ◽  
E. Michael Gertz ◽  
Göran Elmberger ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Phylogenetic Analysis ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Copy Number ◽  
Poor Prognosis ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue ◽  
Copy Number Changes

Poor prognosis in patients with stage I and II oral tongue squamous cell carcinoma

Cancer ◽  
2008 ◽  
Vol 112 (2) ◽  
pp. 345-351 ◽  
Author(s):  
Kyle Rusthoven ◽  
Ari Ballonoff ◽  
David Raben ◽  
Changhu Chen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Tongue Squamous Cell Carcinoma ◽  
Stage I ◽  
Oral Tongue

Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma

Cancer ◽  
1999 ◽  
Vol 85 (5) ◽  
pp. 1011-1017 ◽  
Author(s):  
Hiroyuki Mineta ◽  
Katsutoshi Miura ◽  
Ikuko Suzuki ◽  
Satoru Takebayashi ◽  
Hajime Amano ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue

scholarly journals EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma

2009 ◽  
Vol 45 (9) ◽  
pp. 1700-1708 ◽  
Author(s):  
Michael Ryott ◽  
Darawalee Wangsa ◽  
Kerstin Heselmeyer-Haddad ◽  
Johan Lindholm ◽  
Göran Elmberger ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Copy Number ◽  
Gene Copy Number ◽  
Tongue Squamous Cell Carcinoma ◽  
Gene Copy ◽  
Protein Overexpression ◽  
Oral Tongue

scholarly journals Decreased expression of BATF2 is significantly associated with poor prognosis in oral tongue squamous cell carcinoma

2013 ◽  
Vol 31 (1) ◽  
pp. 169-174 ◽  
Author(s):  
HAOJIE WEN ◽  
YAJUN CHEN ◽  
ZEDONG HU ◽  
QIAO MO ◽  
JINYONG TANG ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Tongue Squamous Cell Carcinoma ◽  
Oral Tongue

scholarly journals Decreased expression of Beclin-1 is significantly associated with a poor prognosis in oral tongue squamous cell carcinoma

2016 ◽  
Vol 14 (2) ◽  
pp. 1567-1573 ◽  
Author(s):  
Zedong Hu ◽  
Zhaoming Zhong ◽  
Shaohui Huang ◽  
Haojie Wen ◽  
Xue Chen ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Tongue Squamous Cell Carcinoma ◽  
Beclin 1 ◽  
Oral Tongue

scholarly journals Deregulation of extracellular matrix modeling with molecular prognostic markers revealed by transcriptome sequencing and validations in Oral Tongue squamous cell carcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Soundara Viveka Thangaraj ◽  
Vidyarani Shyamsundar ◽  
Arvind Krishnamurthy ◽  
Vijayalakshmi Ramshankar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Prognosis ◽  
Prognostic Markers ◽  
Early Stage ◽  
Tongue Squamous Cell Carcinoma ◽  
Marker Genes ◽  
Oral Tongue ◽  
Node Metastasis

AbstractOral Tongue Squamous Cell Carcinoma (OTSCC), a distinct sub-group of head and neck cancers, is characteristically aggressive in nature with a higher incidence of recurrence and metastasis. Recent advances in therapeutics have not improved patient survival. The phenomenon of occult node metastasis, even among the purportedly good prognosis group of early-stage and node-negative tongue tumors, leads to a high incidence of locoregional failure in OTSCC which needs to be addressed. In the current study, transcriptome analysis of OTSCC patients identified the key genes and deregulated pathways. A panel of 26 marker genes was shortlisted and validated using real-time PCR in a prospective cohort of 100 patients. The gene expression was correlated with clinicopathological features including occult node metastasis, survival, and therapeutic outcome. The up-regulation of a panel of 6 genes namely, matrix metalloproteinase 9 (MMP9), Laminin subunit Gamma 2 (LAMC2), Desmoglein 2 (DSG2), Plasminogen Activator Urokinase (PLAU), Forkhead Box M1 (FOXM1), and Myosin 1B (MYO1B) was associated with failure of treatment in the early stage (T1, T2). Up-regulation of Tenacin C (TNC) and Podoplanin (PDPN) was significantly correlated with occult node positivity. Immunohistochemical analysis of LAMC2, MMP9, and E-Cadherin (ECAD) confirmed these markers to be indicators of poor prognosis. We propose this panel of valuable prognostic markers can be clinically useful to identify poor prognosis and occult node metastasis in OTSCC patients.

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