scholarly journals Engagement of signaling pathways of protease-activated receptor 2 and μ-opioid receptor in bone cancer pain and morphine tolerance

2015 ◽  
Vol 137 (6) ◽  
pp. 1475-1483 ◽  
Author(s):  
Yanju Bao ◽  
Yebo Gao ◽  
Wei Hou ◽  
Liping Yang ◽  
Xiangying Kong ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Signaling Pathways ◽  
Opioid Receptor ◽  
Bone Cancer ◽  
Morphine Tolerance ◽  
Bone Cancer Pain ◽  
Μ Opioid Receptor ◽  
Protease Activated Receptor 2

scholarly journals Effect of the Norepinephrine Transporter (NET) Inhibition on μ-Opioid Receptor (MOR)-Induced Anti-nociception in a Bone Cancer Pain Model

2014 ◽  
Vol 125 (3) ◽  
pp. 264-273 ◽  
Author(s):  
Hiroko Ono ◽  
Atsushi Nakamura ◽  
Tomoe Kanbara ◽  
Kazuhisa Minami ◽  
Shunji Shinohara ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Receptor ◽  
Bone Cancer ◽  
Norepinephrine Transporter ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Μ Opioid Receptor

scholarly journals Differential activation of the μ-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model

2012 ◽  
Vol 168 (2) ◽  
pp. 375-388 ◽  
Author(s):  
Atsushi Nakamura ◽  
Minoru Hasegawa ◽  
Kazuhisa Minami ◽  
Tomoe Kanbara ◽  
Takako Tomii ◽  
...  
Keyword(s):  
Cancer Pain ◽  
Opioid Receptor ◽  
Bone Cancer ◽  
Brain Regions ◽  
Bone Cancer Pain ◽  
Pain Model ◽  
Differential Activation ◽  
Μ Opioid Receptor

scholarly journals Effects of Intraperitoneal and Intrathecal Morphine Analgesia on the Expression of μ-Opioid Receptors in Bone Cancer Pain Rats

Dose-Response ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 155932581988287 ◽  
Author(s):  
Wei Liu ◽  
Heqi Liu ◽  
Zongde Zhang ◽  
Jiapeng Huang
Keyword(s):  
Cancer Pain ◽  
Opioid Receptor ◽  
Intrathecal Morphine ◽  
Bone Cancer ◽  
Receptor Expression ◽  
Bone Cancer Pain ◽  
Control Group ◽  
Expression Levels ◽  
Significant Difference ◽  
Μ Opioid Receptor

Backgrounds: This study compared analgesic effects and μ-opioid receptor expression levels during long-term intraperitoneal and intrathecal treatment in a bone cancer pain rat. Methods: Twenty-four female Sprague-Dawley rats were injected Walker 256 tumor cells into the femur to create a bone cancer pain model. The control group was injected with saline intraperitoneally and intrathecally. The intraperitoneal group was injected with morphine intraperitoneally and saline intrathecally. The intrathecal group was injected saline intraperitoneally and morphine intrathecally. Changes in pain threshold, μ-opioid receptor expression levels in spinal cord, and tumor tissue were compared between 3 groups. Results: The intrathecal morphine group and the intraperitoneal group showed no difference in analgesia effects ( P > .05). Western blot and immunohistochemical staining of μ-opioid receptors demonstrated that its level in the intrathecal group was significantly lower than the intraperitoneal group ( P < .05) and without significant difference with the control group ( P > .05). The expression levels of μ-opioid receptor in the spinal cord tissue did not reveal a difference among these 3 groups ( P > .05). Conclusion: Intrathecal group and intraperitoneal group showed significant difference in μ-opioid receptor expressions although with no difference in analgesia effects. Long-term intrathecal morphine administration provided similar analgesia compared to systemic morphine.

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