scholarly journals Association between height and thyroid cancer risk: A meta-analysis of prospective cohort studies

2015 ◽  
Vol 137 (6) ◽  
pp. 1484-1490 ◽  
Author(s):  
Zhaohai Jing ◽  
Xu Hou ◽  
Ying Liu ◽  
Shengli Yan ◽  
Robin Wang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Prospective Cohort Studies ◽  
Thyroid Cancer Risk

scholarly journals Association between Sleep Duration and Cancer Risk: A Meta-Analysis of Prospective Cohort Studies

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74723 ◽  
Author(s):  
Yan Lu ◽  
Nong Tian ◽  
Jie Yin ◽  
Yuhua Shi ◽  
Zhenping Huang
Keyword(s):  
Cancer Risk ◽  
Cohort Studies ◽  
Sleep Duration ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Prospective Cohort Studies

scholarly journals Blood DNA methylation and breast cancer risk: a meta-analysis of four prospective cohort studies

2019 ◽  
Vol 21 (1) ◽  
Author(s):  
Clara Bodelon ◽  
Srikant Ambatipudi ◽  
Pierre-Antoine Dugué ◽  
Annelie Johansson ◽  
Joshua N. Sampson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Blood Collection ◽  
Prospective Cohort Studies ◽  
Average Methylation

Abstract Background Environmental and genetic factors play an important role in the etiology of breast cancer. Several small blood-based DNA methylation studies have reported risk associations with methylation at individual CpGs and average methylation levels; however, these findings require validation in larger prospective cohort studies. To investigate the role of blood DNA methylation on breast cancer risk, we conducted a meta-analysis of four prospective cohort studies, including a total of 1663 incident cases and 1885 controls, the largest study of blood DNA methylation and breast cancer risk to date. Methods We assessed associations with methylation at 365,145 CpGs present in the HumanMethylation450 (HM450K) Beadchip, after excluding CpGs that did not pass quality controls in all studies. Each of the four cohorts estimated odds ratios (ORs) and 95% confidence intervals (CI) for the association between each individual CpG and breast cancer risk. In addition, each study assessed the association between average methylation measures and breast cancer risk, adjusted and unadjusted for cell-type composition. Study-specific ORs were combined using fixed-effect meta-analysis with inverse variance weights. Stratified analyses were conducted by age at diagnosis (< 50, ≥ 50), estrogen receptor (ER) status (+/−), and time since blood collection (< 5, 5–10, > 10 years). The false discovery rate (q value) was used to account for multiple testing. Results The average age at blood draw ranged from 52.2 to 62.2 years across the four cohorts. Median follow-up time ranged from 6.6 to 8.4 years. The methylation measured at individual CpGs was not associated with breast cancer risk (q value > 0.59). In addition, higher average methylation level was not associated with risk of breast cancer (OR = 0.94, 95% CI = 0.85, 1.05; P = 0.26; P for study heterogeneity = 0.86). We found no evidence of modification of this association by age at diagnosis (P = 0.17), ER status (P = 0.88), time since blood collection (P = 0.98), or CpG location (P = 0.98). Conclusions Our data indicate that DNA methylation measured in the blood prior to breast cancer diagnosis in predominantly postmenopausal women is unlikely to be associated with substantial breast cancer risk on the HM450K array. Larger studies or with greater methylation coverage are needed to determine if associations exist between blood DNA methylation and breast cancer risk.

scholarly journals Coffee consumption is not associated with ovarian cancer risk: a dose-response meta-analysis of prospective cohort studies

Oncotarget ◽  
2018 ◽  
Vol 9 (29) ◽  
pp. 20807-20815 ◽  
Author(s):  
Massimiliano Berretta ◽  
Agnieszka Micek ◽  
Alessandra Lafranconi ◽  
Sabrina Rossetti ◽  
Raffaele Di Francia ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Dose Response ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Coffee Consumption ◽  
Ovarian Cancer Risk ◽  
Prospective Cohort Studies

scholarly journals Tooth loss and cancer risk: a dose-response meta analysis of prospective cohort studies

Oncotarget ◽  
2017 ◽  
Vol 9 (19) ◽  
pp. 15090-15100 ◽  
Author(s):  
Jun Shi ◽  
Weidong Leng ◽  
Lunhua Zhao ◽  
Cai Deng ◽  
Chenli Xu ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Cohort Studies ◽  
Dose Response ◽  
Prospective Cohort ◽  
Tooth Loss ◽  
Meta Analysis ◽  
Prospective Cohort Studies
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