Tumor-associated macrophages stimulate the proliferation of murine tumor cells surviving treatment with the oncolytic cyclophosphamide analogue ASTA Z-7557:In vivo implications

1984 ◽  
Vol 34 (6) ◽  
pp. 883-890 ◽  
Author(s):  
Robert Evans ◽  
Theodore Duffy ◽  
Richard T. Cullen
Keyword(s):  
Tumor Cells ◽  
Tumor Associated Macrophages ◽  
Murine Tumor ◽  
Asta Z 7557 ◽  
Murine Tumor Cells

In vivo suppressive effects of copoly(glycolic/L-lactic acid) microspheres containing CDDP on murine tumor cells

1996 ◽  
Vol 42 (2) ◽  
pp. 175-184 ◽  
Author(s):  
K. Itoi ◽  
C-Y. Tabata ◽  
O. Ike ◽  
Y. Shimizu ◽  
M. Kuwabara ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Tumor Cells ◽  
Murine Tumor ◽  
Murine Tumor Cells

The in vivo cytostatic effect induced by Propionibacterium granulosum on murine tumor cells

1980 ◽  
Vol 98 (1) ◽  
pp. 51-58 ◽  
Author(s):  
P. Janik ◽  
W. Roszkowski ◽  
H. L. Ko ◽  
S. Szmigielski ◽  
G. Pulverer ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Cytostatic Effect ◽  
Murine Tumor ◽  
Propionibacterium Granulosum ◽  
Murine Tumor Cells

Inhibitory Effect of Gramicidin S on the Growth of Murine Tumor Cells in vitro and in vivo

Oncology ◽  
1984 ◽  
Vol 41 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Kouji Okamoto ◽  
Yoshifumi Tomita ◽  
Hiroo Yonezawa ◽  
Tomio Hirohata ◽  
Ryohei Ogura ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Inhibitory Effect ◽  
Murine Tumor ◽  
Gramicidin S ◽  
Murine Tumor Cells

scholarly journals A reassessment of the role of B7-1 expression in tumor rejection.

1995 ◽  
Vol 182 (5) ◽  
pp. 1415-1421 ◽  
Author(s):  
T C Wu ◽  
A Y Huang ◽  
E M Jaffee ◽  
H I Levitsky ◽  
D M Pardoll
Keyword(s):  
T Cells ◽  
Tumor Cells ◽  
Cd8 T Cells ◽  
Tumor Rejection ◽  
Type B ◽  
Wild Type ◽  
Systemic Immunity ◽  
Murine Tumor

Introduction of the B7-1 gene into murine tumor cells can result in rejection of the B7-1 transductants and, in some cases, systemic immunity to subsequent challenge with the nontransduced tumor cells. These effects have been largely attributed to the function of B7-1 as a costimulator in directly activating tumor specific, major histocompatibility class I-restricted CD8+ T cells. We examined the role of B7-1 expression in the direct rejection as well as in the induction of systemic immunity to a nonimmunogenic murine tumor. B-16 melanoma cells with high levels of B7-1 expression did not grow in C57BL/6 recipient mice, while wild-type B-16 cells and cells with low B7-1 expression grew progressively within 21 d. In mixing experiments with B7-1hi and wild-type B-16 cells, tumors grew out in vivo even when a minority of cells were B7-1-. Furthermore, the occasional tumors that grew out after injection of 100% B-16 B7-1hi cells showed markedly decreased B7-1 expression. In vivo antibody depletions showed that NK1.1 and CD8+ T cells, but not CD4+ T cells, were essential for the in vivo rejection of tumors. Animals that rejected B-16 B7-1hi tumors did not develop enhanced systemic immunity against challenge with wild-type B-16 cells. These results suggest that a major role of B7-1 expression by tumors is to mediate direct recognition and killing by natural killer cells. With an intrinsically nonimmunogenic tumor, this direct killing does not lead to enhanced systemic immunity.

Expression of Ly-6, a marker for highly malignant murine tumor cells, is regulated by growth conditions and stress

1998 ◽  
Vol 77 (2) ◽  
pp. 306-313 ◽  
Author(s):  
Alexandra Treister ◽  
Orit Sagi-Assif ◽  
Michal Meer ◽  
Nechama I. Smorodinsky ◽  
Romema Anavi ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Growth Conditions ◽  
Murine Tumor ◽  
Murine Tumor Cells

Echinococcus multilocularis: In vitro secretion of antigen by hybridomas from metacestode germinal cells and murine tumor cells

1989 ◽  
Vol 68 (2) ◽  
pp. 186-191 ◽  
Author(s):  
Angela Dieckmann-Schuppert ◽  
Andreas Ruppel ◽  
Reinhard Burger ◽  
Werner Frank
Keyword(s):  
Tumor Cells ◽  
Echinococcus Multilocularis ◽  
Murine Tumor ◽  
Germinal Cells ◽  
Murine Tumor Cells
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