Serum, pituitary and urine concentrations of prolactin and growth hormone in eight strains of mice with varying incidence of mammary tumors

1979 ◽  
Vol 24 (4) ◽  
pp. 430-437 ◽  
Author(s):  
Y. N. Sinha ◽  
G. Vlahakis ◽  
W. P. Vanderlaan
Keyword(s):  
Growth Hormone ◽  
Mammary Tumors ◽  
Urine Concentrations

scholarly journals Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice.

1997 ◽  
Vol 100 (11) ◽  
pp. 2744-2751 ◽  
Author(s):  
H Wennbo ◽  
M Gebre-Medhin ◽  
A Gritli-Linde ◽  
C Ohlsson ◽  
O G Isaksson ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Transgenic Mice ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Prolactin Receptor ◽  
Mammary Tumors

scholarly journals Mammary Tumors Growing in the Absence of Growth Hormone Are More Sensitive to Doxorubicin Than Wild-Type Tumors

Endocrinology ◽  
2021 ◽  
Vol 162 (4) ◽  
Author(s):  
Daniel D Lantvit ◽  
Christopher J Unterberger ◽  
Michelle Lazar ◽  
Paige D Arneson ◽  
Colin A Longhurst ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Hormone ◽  
Endogenous Growth ◽  
Mammary Tumors ◽  
Wild Type ◽  
Sprague Dawley ◽  
Doxorubicin Treatment ◽  
Sprague Dawley Rats ◽  
Almost All ◽  
Treat Breast Cancer

Abstract Previously, we reported that N-methyl-N-nitrosourea (MNU)-induced mammary tumors could be established in mutant spontaneous dwarf rats (SDRs), which lack endogenous growth hormone (GH) by supplementing with exogenous GH, and almost all such tumors regressed upon GH withdrawal. When the highly inbred SDR line was outcrossed to wild-type (WT) Sprague-Dawley rats, MNU-induced mammary tumors could still be established in resulting outbred SDRs by supplementing with exogenous GH. However, unlike tumors in inbred SDRs, 65% of mammary tumors established in outbred SDRs continued growth after GH withdrawal. We further tested whether these tumors were more sensitive to doxorubicin than their WT counterparts. To accomplish this, MNU-induced mammary tumors were established in WT rats and in SDRs supplemented with exogenous GH. Once mammary tumors reached 1 cm3 in size, exogenous GH was withdrawn from SDRs, and the subset that harbored tumors that continued or resumed growth in the absence of GH were selected for doxorubicin treatment. Doxorubicin was then administered in 6 injections over 2 weeks at 2.5 mg/kg or 1.25 mg/kg for both the WT and SDR groups. The SDR mammary tumors that had been growing in the absence of GH regressed at both doxorubicin doses while WT tumors continued to grow robustly. The regression of SDR mammary tumors treated with 1.25 mg/kg doxorubicin was accompanied by reduced proliferation and dramatically higher apoptosis relative to the WT mammary tumors treated with 1.25 mg/kg doxorubicin. These data suggest that downregulating GH signaling may decrease the doxorubicin dose necessary to effectively treat breast cancer.

scholarly journals Expression and Molecular Characterization of the Growth Hormone Receptor in Canine Mammary Tissue and Mammary Tumors

Endocrinology ◽  
1999 ◽  
Vol 140 (12) ◽  
pp. 5907-5914 ◽  
Author(s):  
Evert van Garderen ◽  
Hein J. A. van der Poel ◽  
Joost F. Swennenhuis ◽  
Esther H. J. Wissink ◽  
Gerard R. Rutteman ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Molecular Characterization ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Mammary Tumors ◽  
Mammary Tissue

Great Increase of Numbers of Virus Particles by Irradiating C3H Mouse Mammary Tumors Transplanted into Male Mice

1972 ◽  
Vol 30 ◽  
pp. 272-273
Author(s):  
P. J. Melnick ◽  
J. W. Cha ◽  
E. Samouhos
Keyword(s):  
Subcutaneous Tissue ◽  
Mammary Tumors ◽  
The Body ◽  
X Ray ◽  
Virus Particles ◽  
Mouse Mammary Tumors ◽  
Transplantable Tumors ◽  
C3h Mice ◽  
Cobalt Radiation ◽  
Enzyme Changes

Spontaneous mammary tumors in females of a high tumor strain of C3H mice were cut into small fragments that were Implanted into the subcutaneous tissue of the back of males of the same strain, where they grew as transplantable tumors. When about Cm. In diameter daily fractional radiation was begun, applied to the tumors, the rest of the body being shielded by a lead shield. Two groups were treated with 150 and 200 r X-ray dally, of half value layer 0.6mm. copper; a third group was treated with 500 r cobalt radiation dally. The primary purpose was to examine the enzyme changes during radiation, with histochemlcal technics.

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

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