Longitudinal study of epstein-barr virus antibody titers and excretion in pediatric patients with Hodgkin's disease

1978 ◽  
Vol 22 (5) ◽  
pp. 521-527 ◽  
Author(s):  
Beverly Lange ◽  
Allan Arbeter ◽  
John Hewetson ◽  
Werner Henle
Keyword(s):  
Longitudinal Study ◽  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Pediatric Patients ◽  
Hodgkin’S Disease ◽  
Virus Antibody ◽  
Barr Virus ◽  
Antibody Titers ◽  
Epstein Barr

Evaluation of epstein-barr virus antibody patterns and detection of viral markers in the biopsies of patients with Hodgkin's disease

1994 ◽  
Vol 59 (1) ◽  
pp. 48-50 ◽  
Author(s):  
Paul H. Levine ◽  
Gorm Pallesen ◽  
Peter Ebbesen ◽  
Nancy Harris ◽  
Alfred S. Evans ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Virus Antibody ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Epstein-Barr virus and familial Hodgkin's disease

Blood ◽  
1996 ◽  
Vol 88 (8) ◽  
pp. 3160-3165 ◽  
Author(s):  
AY Lin ◽  
DW Kingma ◽  
ET Lennette ◽  
TR Fears ◽  
JM Whitehouse ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Geometric Mean ◽  
Barr Virus ◽  
Tumor Tissues ◽  
Antibody Titers ◽  
Lower Titer ◽  
Epstein Barr ◽  
And Control

Several studies suggest that the Epstein-Barr virus (EBV) is etiologically linked to Hodgkin's disease (HD). This study was undertaken to examine the role of EBV in familial HD (FHD). Among 60 FHD patients from 27 families with two or more cases per family, we tested available paraffinized tumor tissues from 46 cases by in situ hybridization for EBV-encoded RNA (EBER1) expression. Thirteen of 46 FHD patients (28%) had EBER1 expressed in the Reed-Sternberg cells. Concordance rate of EBV positivity was evaluated among 34 first-degree related pairs from 17 families for which both cases had available paraffinized tumor tissues. Only two of 17 pairs were concordant for EBER1 positivity. There was no excess of positive concordance (P = .18). Serologically, FHD patients had higher geometric mean antibody titers (GMTs) to the viral capsid antigen (VCA) and early antigen D (EA-D). There was no difference in seroprevalence between patients and control groups, nor was there concordance in elevated serology among 15 pairs of first-degree related FHD cases. Young adult unaffected family members (UFM) may not react to EBV in the same way as the general population as evidenced by the lower titer of VCA, although not statistically significant, and significantly lower titers of EA-D, compared with age-matched controls. While EBV might have some role in a subset of HD, lack of concordance of EBER1 expression and EBV serology among the FHD cases in the same family suggest that EBV does not play an important role in FHD.

scholarly journals Elevated antibody titers to epstein-barr virus in Hodgkin's disease

Cancer ◽  
1971 ◽  
Vol 27 (2) ◽  
pp. 416-421 ◽  
Author(s):  
Paul H. Levine ◽  
Dharam V. Ablashi ◽  
Costan W. Berard ◽  
Paul P. Carbone ◽  
Deward E. Waggoner ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Barr Virus ◽  
Antibody Titers ◽  
Epstein Barr

Influence of Epstein–Barr Virus Genomes on Patient Survival in Hodgkin’s Disease

1992 ◽  
Vol 98 (3) ◽  
pp. 319-323 ◽  
Author(s):  
Christian Fellbaum ◽  
Martin-Leo Hansmann ◽  
Hans Niedermeyer ◽  
Irmgard Kraus ◽  
Martti J. Alavaikko ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Patient Survival ◽  
Hodgkin’S Disease ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Genomes

Comparison of Epstein-Barr Virus Markers in Reed-Sternberg Cells in Adult Hodgkin's Disease Tissues from an Industrialized and a Developing Country

1995 ◽  
Vol 17 (1-2) ◽  
pp. 163-168 ◽  
Author(s):  
Mohammed I. Belkaid ◽  
Josette Briegre ◽  
Zahia Djebbara ◽  
Kheira Beldjord ◽  
Jean Marie Andrieu ◽  
...  
Keyword(s):  
Developing Country ◽  
Hodgkin's Disease ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Barr Virus ◽  
Epstein Barr

HIGH FREQUENCY OF EPSTEIN-BARR VIRUS GENOME IN HIV-POSITIVE PATIENTS WITH HODGKIN'S DISEASE

The Lancet ◽  
1989 ◽  
Vol 333 (8652) ◽  
pp. 1458 ◽  
Author(s):  
Stefania Uccini ◽  
Francesca Monardo ◽  
LuigiP. Ruco ◽  
CarloD. Baroni ◽  
Alberto Faggioni ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
High Frequency ◽  
Epstein Barr Virus ◽  
Hodgkin’S Disease ◽  
Virus Genome ◽  
Hiv Positive ◽  
Barr Virus ◽  
Epstein Barr
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