Platelet—tumor-cell interactions in mice. The role of platelets in the spread of malignant disease

1973 ◽  
Vol 11 (3) ◽  
pp. 704-718 ◽  
Author(s):  
Gabriel J. Gasic ◽  
Tatiana B. Gasic ◽  
Norbel Galanti ◽  
Thomas Johnson ◽  
Scott Murphy
Keyword(s):  
Tumor Cell ◽  
Malignant Disease ◽  
Cell Interactions

Role of Eicosanoids in Tumor Cell-Platelet-Endothelial Cell Interactions

1987 ◽  
pp. 63-69 ◽  
Author(s):  
Bruce W. Steinert ◽  
Bonnie F. Sloane ◽  
David G. Menter ◽  
John D. Crissman ◽  
John D. Taylor ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Tumor Cell ◽  
Cell Interactions

scholarly journals Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model

2014 ◽  
Vol 11 (1) ◽  
pp. 17 ◽  
Author(s):  
Abhineet Uppal ◽  
Sean C Wightman ◽  
Sabha Ganai ◽  
Ralph R Weichselbaum ◽  
Gary An
Keyword(s):  
Tumor Cell ◽  
Essential Role ◽  
Cell Interactions ◽  
Agent Based Model ◽  
Agent Based

Abstract 3191: The role of rigidity in myeloid-tumor cell interactions in bone

2015 ◽  
Author(s):  
Denise Buenrostro ◽  
Ushashi Dadwal ◽  
Scott Guelcher ◽  
Julie Sterling
Keyword(s):  
Tumor Cell ◽  
Cell Interactions

Role of Heparanase in Platelet and Tumor Cell Interactions with the Subendothelial Extracellular Matrix

1987 ◽  
Vol 13 (04) ◽  
pp. 475-488 ◽  
Author(s):  
Amiram Eldor ◽  
Matia Bar-Ner ◽  
Joachim Yahalom ◽  
Zvi Fuks ◽  
Israel Vlodavsky
Keyword(s):  
Extracellular Matrix ◽  
Tumor Cell ◽  
Cell Interactions

Tumor Cell-Endothelial Cell Interactions During Blood Borne Metastasis: Role of Specific Adhesion, Motility, and Growth Molecules

1993 ◽  
pp. 221-243
Author(s):  
Garth L. Nicolson ◽  
Timothy J. Yeatman ◽  
Robert J. Tressler ◽  
Timothy V. Updyke ◽  
Jun-ichi Hamada ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Tumor Cell ◽  
Cell Interactions

A Molecular Approach to Immunoscintigraphy: A Study of the T-Antigen Conformation on the Surface of Tumors

1987 ◽  
Vol 26 (01) ◽  
pp. 1-6 ◽  
Author(s):  
S. Selvaraj ◽  
M. R. Suresh ◽  
G. McLean ◽  
D. Willans ◽  
C. Turner ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumor Cell ◽  
T Antigen ◽  
Human Carcinomas ◽  
Animal Tumor ◽  
Synthetic Antigens

The role of glycoconjugates in tumor cell differentiation has been well documented. We have examined the expression of the two anomers of the Thomsen-Friedenreich antigen on the surface of human, canine and murine tumor cell membranes both in vitro and in vivo. This has been accomplished through the synthesis of the disaccharide terminal residues in both a and ß configuration. Both entities were used to generate murine monoclonal antibodies which recognized the carbohydrate determinants. The determination of fine specificities of these antibodies was effected by means of cellular uptake, immunohistopathology and immunoscintigraphy. Examination of pathological specimens of human and canine tumor tissue indicated that the expressed antigen was in the β configuration. More than 89% of all human carcinomas tested expressed the antigen in the above anomeric form. The combination of synthetic antigens and monoclonal antibodies raised specifically against them provide us with invaluable tools for the study of tumor marker expression in humans and their respective animal tumor models.

Platelet and Shear Rate Promote Tumor Cell Adhesion to Human Endothelial Extracellular Matrix - Absence of a Role for Platelet Cyclooxygenase

1989 ◽  
Vol 61 (03) ◽  
pp. 485-489 ◽  
Author(s):  
Eva Bastida ◽  
Lourdes Almirall ◽  
Antonio Ordinas
Keyword(s):  
Cell Adhesion ◽  
Shear Rate ◽  
Tumor Cell ◽  
Umbilical Vein ◽  
Blood Platelets ◽  
Flow Conditions ◽  
Tumor Cell Adhesion ◽  
Rate Dependent ◽  
Static Conditions

SummaryBlood platelets are thought to be involved in certain aspects of malignant dissemination. To study the role of platelets in tumor cell adherence to vascular endothelium we performed studies under static and flow conditions, measuring tumor cell adhesion in the absence or presence of platelets. We used highly metastatic human adenocarcinoma cells of the lung, cultured human umbilical vein endothelial cells (ECs) and extracellular matrices (ECM) prepared from confluent EC monolayers. Our results indicated that under static conditions platelets do not significantly increase tumor cell adhesion to either intact ECs or to exposed ECM. Conversely, the studies performed under flow conditions using the flat chamber perfusion system indicated that the presence of 2 × 105 pl/μl in the perfusate significantly increased the number of tumor cells adhered to ECM, and that this effect was shear rate dependent. The maximal values of tumor cell adhesion were obtained, in presence of platelets, at a shear rate of 1,300 sec-1. Furthermore, our results with ASA-treated platelets suggest that the role of platelets in enhancing tumor cell adhesion to ECM is independent of the activation of the platelet cyclooxygenase pathway.

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