scholarly journals ROBO1, a tumor suppressor and critical molecular barrier for localized tumor cells to acquire invasive phenotype: Study in African-American and Caucasian prostate cancer models

2014 ◽  
Vol 135 (11) ◽  
pp. 2493-2506 ◽  
Author(s):  
Aijaz Parray ◽  
Hifzur R. Siddique ◽  
Jacquelyn K. Kuriger ◽  
Shrawan K. Mishra ◽  
Johng S. Rhim ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Tumor Suppressor ◽  
Tumor Cells ◽  
Invasive Phenotype ◽  
Cancer Models

scholarly journals RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression

2017 ◽  
Vol 77 (16) ◽  
pp. 4247-4257 ◽  
Author(s):  
Yongquan Wang ◽  
Jianghua Wang ◽  
Li Zhang ◽  
Omer Faruk Karatas ◽  
Longjiang Shao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene

Therapeutic Effect of Attenuated Salmonella Carrying SiRNA-STAT3 Plasmid on Transplanted Prostate Cancer in Mice

2011 ◽  
Vol 140 ◽  
pp. 7-11
Author(s):  
Zhong Yi Cong ◽  
Yue Zhou ◽  
Shu Han Zhou ◽  
Xue Jian Zhao ◽  
Qing Wei Zhou
Keyword(s):  
Prostate Cancer ◽  
Flow Cytometry ◽  
Tumor Cells ◽  
Therapeutic Effect ◽  
Tumor Volume ◽  
Prostate Cancer Cells ◽  
Rt Pcr ◽  
Expression Levels ◽  
Cancer Models ◽  
Mrna Expression Levels

Objective To observe the therapeutic effect of attenuated Salmonella carrying siRNA-STAT3 plasmid on transplanted prostate cancer in mice, and investigate the mechanism of siRNA-STAT3 inducing apoptosis of prostate cancer cells in mice. Methods The transplanted prostate cancer models of mice were built, and then the mice were randomly divided into Mock group, pGC-Si-Scramble group and pGC-Si-STAT3 group. The general status of the mice was observed and the changes of tumor volume were recorded. The expression levels of mRNA and protein of STAT3 and its downstream genes such as Bcl-2, c-Myc, HIF-1, cyclinD1 were analyzed with RT-PCR and western blotting, and the apoptosis of tumor cells was detected with flow cytometry. Results Compared with the Mock group, the tumor weight and tumor volume in pGC-Si-STAT3 group were significantly decreased (P<0.05). The result of flow cytometry revealed that the early apoptotic rate of tumor cells in pGC-Si-STAT3 group was (29.1±1.6)%, which was significantly higher than that of pGC-Si-Scramble group (14.7±1.4)% and Mock group (8.9±1.8)% (P<0.05). The mRNA expression levels of STAT3 and its downstream genes Bcl-2 and c-Myc in the pGC-Si-STAT3 group were significantly decreased (P<0.05), and the protein expression levels of STAT3 and its downstream genes HIF-1 and cyclinD1 were also decreased (P<0.05), compared with the Mock group. Conclusion The attenuated Salmonella carrying siRNA-STAT3 plasmid could inhibit the growth of transplanted prostate cancer in mice by regulating the expressions of STAT3’s downstream genes and inducing the apoptosis of tumor cells.

285: The Impact of Socioeconomic Factors on Prostate Cancer Outcomes in a Large Series of African-American Patients

2007 ◽  
Vol 177 (4S) ◽  
pp. 95-95
Author(s):  
Atreya Dash ◽  
Peng Lee ◽  
Qin Zhou ◽  
Aaron D. Berger ◽  
Jerome Jean-Gilles ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Socioeconomic Factors ◽  
Large Series ◽  
Cancer Outcomes ◽  
The Impact

1267: Prostate-Specific Antigen Velocity among African-American and White Men Without Prostate Cancer

2004 ◽  
Vol 171 (4S) ◽  
pp. 334-334
Author(s):  
Walter J. Simoneaux ◽  
Caleb B. Bozeman ◽  
Brett S. Carver ◽  
Donald A. Elmajian
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
White Men

Role of exosomes in diagnosis and therapy of prostate cancer

2020 ◽  
Vol 28 (3) ◽  
pp. 399-405
Author(s):  
Fabrizio Fontana ◽  
Olga A. Babenko
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Biological Fluids ◽  
Diagnosis And Treatment ◽  
Diagnosis And Therapy ◽  
The Future ◽  
Important Direction ◽  
Potential Biomarkers

Aim of this letter is to attract the attention of journal readers to the study of exosomes as an important direction in the development of Oncology, in particular, in the diagnosis and treatment of prostate cancer. Exosomes are produced by tumor cells and regulate proliferation, metastasis, and the development of chemoresistance. Their extraction from biological fluids allows further use of these vesicles as potential biomarkers of prostate cancer. In the future, exosomes can be successfully used in the delivery of drugs and other anti-tumor substances to cancer cells.

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