scholarly journals PTPRGinhibition by DNA methylation and cooperation withRASgene activation in childhood acute lymphoblastic leukemia

2014 ◽  
Vol 135 (5) ◽  
pp. 1101-1109 ◽  
Author(s):  
Jianqiao Xiao ◽  
Seung-Tae Lee ◽  
Yuanyuan Xiao ◽  
Xiaomei Ma ◽  
E. Andres Houseman ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia

scholarly journals History of parvovirus B19 infection is associated with a DNA methylation signature in childhood acute lymphoblastic leukemia

Epigenetics ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. 1436-1443 ◽  
Author(s):  
Gisele M. Vasconcelos ◽  
Brock C. Christensen ◽  
E. Andrés Houseman ◽  
Jianqiao Xiao ◽  
Carmen J. Marsit ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
Parvovirus B19 ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
History Of ◽  
Parvovirus B19 Infection

scholarly journals FHIT promoter DNA methylation and expression analysis in childhood acute lymphoblastic leukemia

2017 ◽  
Vol 14 (4) ◽  
pp. 5034-5038
Author(s):  
Gholamreza Bahari ◽  
Mohammad Hashemi ◽  
Majid Naderi ◽  
Simin Sadeghi-Bojd ◽  
Mohsen Taheri
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
Expression Analysis ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Promoter Dna Methylation ◽  
Promoter Dna

scholarly journals DNA methylation and the hygiene hypothesis: connecting respiratory allergy and childhood acute lymphoblastic leukemia

Epigenomics ◽  
2019 ◽  
Vol 11 (13) ◽  
pp. 1519-1537 ◽  
Author(s):  
Sabine AS Langie ◽  
Jessica A Timms ◽  
Patrick De Boever ◽  
Jill A McKay
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
System Development ◽  
Lymphoblastic Leukemia ◽  
Hygiene Hypothesis ◽  
Respiratory Allergy ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Aberrant Methylation ◽  
Immune System Development ◽  
Underlying Mechanisms

Aim: The hygiene hypothesis states that a lack of infection in early-life suppresses immune system development, and is linked to respiratory allergy (RA) and childhood acute lymphoblastic leukemia (ALL) risk. Little is known about underlying mechanisms, but DNA methylation is altered in RA and ALL, and in response to infection. We investigated if aberrant methylation may be in common between these diseases and associated with infection. Materials & methods: RA and ALL disease-associated methylation signatures were compared and related to exposure-to-infection signatures. Results: A significant number of genes overlapped between RA and ALL signatures (p = 0.0019). Significant overlaps were observed between exposure-to-infection signatures and disease-associated signatures. Conclusion: DNA methylation may be a mediating mechanism through which the hygiene hypothesis is associated with RA and ALL risk.

DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia

Blood ◽  
2010 ◽  
Vol 115 (6) ◽  
pp. 1214-1225 ◽  
Author(s):  
Lili Milani ◽  
Anders Lundmark ◽  
Anna Kiialainen ◽  
Jessica Nordlund ◽  
Trond Flaegstad ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
Cross Validation ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Methylation Analysis ◽  
Cell Precursor ◽  
Cpg Sites ◽  
Gene Sets ◽  
Gene Expression Levels

Abstract Despite improvements in the prognosis of childhood acute lymphoblastic leukemia (ALL), subgroups of patients would benefit from alternative treatment approaches. Our aim was to identify genes with DNA methylation profiles that could identify such groups. We determined the methylation levels of 1320 CpG sites in regulatory regions of 416 genes in cells from 401 children diagnosed with ALL. Hierarchical clustering of 300 CpG sites distinguished between T-lineage ALL and B-cell precursor (BCP) ALL and between the main cytogenetic subtypes of BCP ALL. It also stratified patients with high hyperdiploidy and t(12;21) ALL into 2 subgroups with different probability of relapse. By using supervised learning, we constructed multivariate classifiers by external cross-validation procedures. We identified 40 genes that consistently contributed to accurate discrimination between the main subtypes of BCP ALL and gene sets that discriminated between subtypes of ALL and between ALL and controls in pairwise classification analyses. We also identified 20 individual genes with DNA methylation levels that predicted relapse of leukemia. Thus, methylation analysis should be explored as a method to improve stratification of ALL patients. The genes highlighted in our study are not enriched to specific pathways, but the gene expression levels are inversely correlated to the methylation levels.

scholarly journals Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia

2011 ◽  
Vol 35 (10) ◽  
pp. 1345-1349 ◽  
Author(s):  
Seisho Takeuchi ◽  
Masahide Matsushita ◽  
Martin Zimmermann ◽  
Takayuki Ikezoe ◽  
Naoki Komatsu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Acute Lymphoblastic Leukemia ◽  
Clinical Significance ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Aberrant Dna Methylation

Genetic characterization of high hyperdiploidy in childhood acute lymphoblastic leukemia

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
R Vagkopoulou ◽  
C Eckert ◽  
U Ungethüm ◽  
G Körner ◽  
M Stanulla ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Genetic Characterization ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia
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