scholarly journals A bispecific transmembrane antibody simultaneously targeting intra- and extracellular epitopes of the epidermal growth factor receptor inhibits receptor activation and tumor cell growth

2013 ◽  
Vol 134 (11) ◽  
pp. 2547-2559 ◽  
Author(s):  
Nina Müller ◽  
Cord Hartmann ◽  
Sabrina Genßler ◽  
Joachim Koch ◽  
Andrea Kinner ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Tumor Cell ◽  
Growth Factor Receptor ◽  
Receptor Activation ◽  
Tumor Cell Growth ◽  
Epidermal Growth

scholarly journals Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.

1998 ◽  
Vol 101 (2) ◽  
pp. 406-412 ◽  
Author(s):  
D K Moscatello ◽  
M Santra ◽  
D M Mann ◽  
D J McQuillan ◽  
A J Wong ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Tumor Cell ◽  
Growth Factor Receptor ◽  
Tumor Cell Growth ◽  
Epidermal Growth

scholarly journals Correction: DeltaNp63alpha-Mediated Induction of Epidermal Growth Factor Receptor Promotes Pancreatic Cancer Cell Growth and Chemoresistance

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192927
Author(s):  
Alexey V. Danilov ◽  
Divas Neupane ◽  
Archana Sidalaghatta Nagaraja ◽  
Elena V. Feofanova ◽  
Leigh Ann Humphries ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Cell Growth ◽  
Epidermal Growth Factor ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Growth Factor Receptor ◽  
Cancer Cell Growth ◽  
Epidermal Growth

Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation

2002 ◽  
Vol 283 (3) ◽  
pp. L531-L540 ◽  
Author(s):  
Kazuhiro Kohri ◽  
Iris F. Ueki ◽  
Jay A. Nadel
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Neutrophil Elastase ◽  
Growth Factor Receptor ◽  
Receptor Activation ◽  
Cell Culture Supernatant ◽  
Mucin Production ◽  
Egfr Activation ◽  
Epidermal Growth

Neutrophil products are implicated in hypersecretory airway diseases. To determine the mechanisms linking a proteolytic effect of human neutrophil elastase (HNE) and mucin overproduction, we examined the effects of HNE on MUC5AC mucin production in human airway epithelial (NCI-H292) cells. Stimulation with HNE for 5–30 min induced MUC5AC production 24 h later, which was prevented by HNE serine active site inhibitors, implicating a proteolytic effect of HNE. MUC5AC induction was preceded by epidermal growth factor receptor (EGFR) tyrosine phosphorylation and was prevented by selective EGFR tyrosine kinase inhibitors, implicating EGFR activation. HNE-induced MUC5AC production was inhibited by a neutralizing transforming growth factor-α (TGF-α, an EGFR ligand) antibody and by a neutralizing EGFR antibody but not by oxygen free radical scavengers, further implicating TGF-α and ligand-dependent EGFR activation in the response. HNE decreased pro-TGF-α in NCI-H292 cells and increased TGF-α in cell culture supernatant. From these results, we conclude that HNE-induced MUC5AC mucin production occurs via its proteolytic activation of an EGFR signaling cascade involving TGF-α.

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