scholarly journals Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells

2013 ◽  
Vol 134 (7) ◽  
pp. 1571-1582 ◽  
Author(s):  
Yuan-Na Lin ◽  
Jakob R. Izbicki ◽  
Alexandra König ◽  
Jens K. Habermann ◽  
Christine Blechner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colon Carcinoma ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Colon Carcinoma Cells ◽  
Metastatic Capacity

scholarly journals Improved Activation toward Primary Colorectal Cancer Cells by Antigen-Specific Targeting Autologous Cytokine-Induced Killer Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Claudia Schlimper ◽  
Andreas A. Hombach ◽  
Hinrich Abken ◽  
Ingo G. H. Schmidt-Wolf
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Colon Carcinoma ◽  
Ex Vivo ◽  
Carcinoma Cells ◽  
Adoptive Therapy ◽  
Cik Cells ◽  
Colon Carcinoma Cells ◽  
Colorectal Cancer Patients

Adoptive therapy of malignant diseases with cytokine-induced killer (CIK) cells showed promise in a number of trials; the activation of CIK cells from cancer patients towards their autologous cancer cells still needs to be improved. Here, we generated CIK cellsex vivofrom blood lymphocytes of colorectal cancer patients and engineered those cells with a chimeric antigen receptor (CAR) with an antibody-defined specificity for carcinoembryonic antigen (CEA). CIK cells thereby gained a new specificity as defined by the CAR and showed increase in activation towards CEA+colon carcinoma cells, but less in presence of CEA−cells, indicated by increased secretion of proinflammatory cytokines. Redirected CIK activation was superior by CAR-mediated CD28-CD3ζ than CD3ζ signaling only. CAR-engineered CIK cells from colon carcinoma patients showed improved activation against their autologous, primary carcinoma cells from biopsies resulting in more efficient tumour cell lysis. We assume that adoptive therapy with CAR-modified CIK cells shows improved selectivity in targeting autologous tumour lesions.

scholarly journals Selective Cytotoxic Activity of Valinomycin against HT-29 Human Colon Carcinoma Cells via Down-Regulation of GRP78

2006 ◽  
Vol 29 (4) ◽  
pp. 817-820 ◽  
Author(s):  
In-Ja Ryoo ◽  
Hae-Ryong Park ◽  
Soo-Jin Choo ◽  
Ji-Hwan Hwang ◽  
Young-Min Park ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma ◽  
Ht 29

scholarly journals NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells

2009 ◽  
Vol 124 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Young Jun Kim ◽  
Sun Young Yoon ◽  
Jong-Tae Kim ◽  
Seung Cheol Choi ◽  
Jong-Seok Lim ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Colon Carcinoma ◽  
Human Colon ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Colon Carcinoma Cells ◽  
Human Colon Carcinoma

Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells

2012 ◽  
Vol 24 (7) ◽  
pp. 1369-1374 ◽  
Author(s):  
Adar Makovski ◽  
Etai Yaffe ◽  
Sally Shpungin ◽  
Uri Nir
Keyword(s):  
Colon Carcinoma ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Colon Carcinoma Cells ◽  
P53 Activation

scholarly journals Independent down‐regulation of Sep15 and TR1, but not deficiency in both genes, affects cancer phenotypes of mouse colon carcinoma cells

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Petra Akiko Tsuji ◽  
Bradley A Carlson ◽  
Min-Hyuk Yoo ◽  
Xue- Ming Xu ◽  
Salvador Naranjo-Suarez ◽  
...  
Keyword(s):  
Colon Carcinoma ◽  
Carcinoma Cells ◽  
Down Regulation ◽  
Colon Carcinoma Cells ◽  
Mouse Colon ◽  
Cancer Phenotypes
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