scholarly journals A pooled analysis of the outcome of prospective colonoscopic surveillance for familial colorectal cancer

2013 ◽  
Vol 134 (4) ◽  
pp. 939-947 ◽  
Author(s):  
David Mesher ◽  
Isis Dove-Edwin ◽  
Peter Sasieni ◽  
Hans Vasen ◽  
Inge Bernstein ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Pooled Analysis ◽  
Familial Colorectal Cancer ◽  
Colonoscopic Surveillance

scholarly journals Randomized Comparison of Surveillance Intervals in Familial Colorectal Cancer

2015 ◽  
Vol 33 (35) ◽  
pp. 4188-4193 ◽  
Author(s):  
Simone D. Hennink ◽  
Andrea E. van der Meulen-de Jong ◽  
Ron Wolterbeek ◽  
A. Stijn L.P. Crobach ◽  
Marco C.J.M. Becx ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Degree Relative ◽  
Familial Colorectal Cancer ◽  
Colonoscopic Surveillance ◽  
Screening Interval ◽  
Significant Difference ◽  
Surveillance Interval ◽  
Group A ◽  
Group B

Purpose Colonoscopic surveillance is recommended for individuals with familial colorectal cancer (CRC). However, the appropriate screening interval has not yet been determined. The aim of this randomized trial was to compare a 3-year with a 6-year screening interval. Patients and Methods Individuals between ages 45 and 65 years with one first-degree relative with CRC age < 50 years or two first-degree relatives with CRC were selected. Patients with zero to two adenomas at baseline were randomly assigned to one of two groups: group A (colonoscopy at 6 years) or group B (colonoscopy at 3 and 6 years). The primary outcome measure was advanced adenomatous polyps (AAPs). Risk factors studied included sex, age, type of family history, and baseline endoscopic findings. Results A total of 528 patients were randomly assigned (group A, n = 262; group B, n = 266). Intention-to-treat analysis showed no significant difference in the proportion of patients with AAPs at the first follow-up examination at 6 years in group A (6.9%) versus 3 years in group B (3.5%). Also, the proportion of patients with AAPs at the final follow-up examination at 6 years in group A (6.9%) versus 6 years in group B (3.4%) was not significantly different. Only AAPs at baseline was a significant predictor for the presence of AAPs at first follow-up. After correction for the difference in AAPs at baseline, differences between the groups in the rate of AAPs at first follow-up and at the final examination were statistically significant. Conclusion In view of the relatively low rate of AAPs at 6 years and the absence of CRC in group A, we consider a 6-year surveillance interval appropriate. A surveillance interval of 3 years might be considered in patients with AAPs and patients with ≥ three adenomas.

Familial colorectal cancer: The outcome of colonoscopic surveillance in (Dominant) HNPCC and non-HNPCC families

2001 ◽  
Vol 120 (5) ◽  
pp. A742
Author(s):  
Isis Dove-Edwin ◽  
Christopher B. Williams ◽  
Peter Sasieni ◽  
Huw Jw Thomas
Keyword(s):  
Colorectal Cancer ◽  
Familial Colorectal Cancer ◽  
Colonoscopic Surveillance

PROXIMAL ADENOMAS AND COLORECTAL CANCER: TWO SHADOWS IN THE EFFECTIVENESS OF COLONOSCOPIC SURVEILLANCE

2018 ◽  
Author(s):  
L Adán Merino ◽  
M Aldeguer Martínez ◽  
F Valentín Gómez ◽  
J Barrio Antoranz ◽  
R Plaza Santos ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Colonoscopic Surveillance

scholarly journals Familial colorectal cancer risk by subsite of primary cancer: a population-based study in Utah

2015 ◽  
Vol 41 (6) ◽  
pp. 573-580 ◽  
Author(s):  
N. J. Samadder ◽  
K. R. Smith ◽  
G. P. Mineau ◽  
R. Pimentel ◽  
J. Wong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Population Based ◽  
Colorectal Cancer Risk ◽  
Primary Cancer ◽  
Familial Colorectal Cancer ◽  
Population Based Study

scholarly journals Familial colorectal cancer

2015 ◽  
Vol 45 (5) ◽  
pp. 482-491 ◽  
Author(s):  
M. S. Lung ◽  
A. H. Trainer ◽  
I. Campbell ◽  
L. Lipton
Keyword(s):  
Colorectal Cancer ◽  
Familial Colorectal Cancer
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