scholarly journals Serum interleukin-6 associated with hepatocellular carcinoma risk: A nested case-control study

2013 ◽  
Vol 134 (1) ◽  
pp. 154-163 ◽  
Author(s):  
Waka Ohishi ◽  
John B. Cologne ◽  
Saeko Fujiwara ◽  
Gen Suzuki ◽  
Tomonori Hayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Interleukin 6 ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Carcinoma Risk ◽  
Control Study

scholarly journals Re: Hepatocellular Carcinoma Risk factors and Disease Burden in a European Cohort: A Nested Case-Control Study

2012 ◽  
Vol 104 (21) ◽  
pp. 1681-1683 ◽  
Author(s):  
J. Polesel ◽  
M. Montella ◽  
L. Dal Maso ◽  
A. Crispo ◽  
D. Serraino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Disease Burden ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Carcinoma Risk ◽  
Control Study

scholarly journals Nested case-control study: hepatocellular carcinoma risk after hepatitis B surface antigen seroclearance

2016 ◽  
Vol 43 (11) ◽  
pp. 1197-1207 ◽  
Author(s):  
P. P. Gounder ◽  
L. R. Bulkow ◽  
M. Snowball ◽  
S. Negus ◽  
P. R. Spradling ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Case Control Study ◽  
Hepatitis B Surface Antigen ◽  
Case Control ◽  
Nested Case Control ◽  
Carcinoma Risk ◽  
Control Study

scholarly journals Hepatocellular Carcinoma Risk Factors and Disease Burden in a European Cohort: A Nested Case-Control Study

2011 ◽  
Vol 103 (22) ◽  
pp. 1686-1695 ◽  
Author(s):  
D. Trichopoulos ◽  
C. Bamia ◽  
P. Lagiou ◽  
V. Fedirko ◽  
E. Trepo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Disease Burden ◽  
Case Control Study ◽  
Case Control ◽  
Nested Case Control ◽  
Carcinoma Risk ◽  
Control Study

scholarly journals Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study

2008 ◽  
Vol 89 (11) ◽  
pp. 2882-2890 ◽  
Author(s):  
Zhong-Liao Fang ◽  
Caroline A. Sabin ◽  
Bai-Qing Dong ◽  
Shao-Chao Wei ◽  
Qin-Yan Chen ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Risk Factor ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Case Control Study ◽  
Case Control ◽  
Deletion Mutations ◽  
B Virus ◽  
Nested Case Control ◽  
Control Study

A matched nested case–control study of 33 paired cases and controls was conducted, based on a study cohort in Long An county, Guangxi, China, to determine whether infection with hepatitis B virus (HBV) with pre-S deletions is independently associated with the development of hepatocellular carcinoma (HCC), without the confounding effects of basal core promoter (BCP) double mutations. The prevalence of pre-S deletions was significantly higher in HCC (45.5 %, 15 of 33) than the controls (18.2 %, 6 of 33) (P<0.01), under the control of the influence of BCP double mutations. Most of the pre-S deletions occurred in, or involved, the 5′ half of the pre-S2 region and the difference between HCC (93.3 %, 14 of 15) and controls (66.7 %, four of six) was significant for this region (P=0.015). There was no significant difference in pre-S deletions between the BCP mutant group and BCP wild-type group (P>0.05), nor was the prevalence of pre-S deletions significantly different between genotypes B and C (P>0.1). These results suggest that pre-S deletions constitute an independent risk factor for HCC and their emergence and effect are independent of BCP mutations. The 5′ terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC.

Sign in / Sign up

Export Citation Format

Share Document