scholarly journals Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

2013 ◽  
Vol 133 (8) ◽  
pp. 1936-1944 ◽  
Author(s):  
Jill T. Schappa ◽  
Aric M. Frantz ◽  
Brandi H. Gorden ◽  
Erin B. Dickerson ◽  
Daniel A. Vallera ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Stem Cell ◽  
Cell Subpopulation ◽  
Epidermal Growth

scholarly journals Hemangiosarcoma and its cancer stem cell sub-population are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

2013 ◽  
Vol 7 (S2) ◽  
Author(s):  
Jill T Schappa ◽  
Aric M Frantz ◽  
Brandi H Gorden ◽  
Erin B Dickerson ◽  
Daniel A Vallera ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Cancer Stem Cell ◽  
Epidermal Growth

Epidermal Growth Factor Receptor Variant III Contributes to Cancer Stem Cell Phenotypes in Invasive Breast Carcinoma

2012 ◽  
Vol 72 (10) ◽  
pp. 2657-2671 ◽  
Author(s):  
Catherine A. Del Vecchio ◽  
Kristin C. Jensen ◽  
Ryan T. Nitta ◽  
A. Hunter Shain ◽  
Craig P. Giacomini ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Stem Cell ◽  
Growth Factor ◽  
Breast Carcinoma ◽  
Epidermal Growth Factor ◽  
Cancer Stem Cell ◽  
Growth Factor Receptor ◽  
Invasive Breast Carcinoma ◽  
Epidermal Growth ◽  
Cell Phenotypes

scholarly journals CG6015 controls spermatogonia transit-amplifying divisions by epidermal growth factor receptor signaling in Drosophila testes

2021 ◽  
Vol 12 (5) ◽  
Author(s):  
Jun Yu ◽  
Qianwen Zheng ◽  
Zhiran Li ◽  
Yunhao Wu ◽  
Yangbo Fu ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Stem Cell ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Gene Set Enrichment Analysis ◽  
Germline Stem Cell ◽  
Egfr Signaling ◽  
Egfr Signaling Pathway ◽  
Epidermal Growth

AbstractSpermatogonia transit-amplifying (TA) divisions are crucial for the differentiation of germline stem cell daughters. However, the underlying mechanism is largely unknown. In the present study, we demonstrated that CG6015 was essential for spermatogonia TA-divisions and elongated spermatozoon development in Drosophila melanogaster. Spermatogonia deficient in CG6015 inhibited germline differentiation leading to the accumulation of undifferentiated cell populations. Transcriptome profiling using RNA sequencing indicated that CG6015 was involved in spermatogenesis, spermatid differentiation, and metabolic processes. Gene Set Enrichment Analysis (GSEA) revealed the relationship between CG6015 and the epidermal growth factor receptor (EGFR) signaling pathway. Unexpectedly, we discovered that phosphorylated extracellular regulated kinase (dpERK) signals were activated in germline stem cell (GSC)-like cells after reduction of CG6015 in spermatogonia. Moreover, Downstream of raf1 (Dsor1), a key downstream target of EGFR, mimicked the phenotype of CG6015, and germline dpERK signals were activated in spermatogonia of Dsor1 RNAi testes. Together, these findings revealed a potential regulatory mechanism of CG6015 via EGFR signaling during spermatogonia TA-divisions in Drosophila testes.

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