scholarly journals Insulin-like growth factor pathway genes and blood concentrations, dietary protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort Consortium (BPC3)

2013 ◽  
Vol 133 (2) ◽  
pp. 495-504 ◽  
Author(s):  
Konstantinos K. Tsilidis ◽  
Ruth C. Travis ◽  
Paul N. Appleby ◽  
Naomi E. Allen ◽  
Sara Lindström ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Dietary Protein ◽  
Insulin Like Growth Factor ◽  
Blood Concentrations ◽  
Breast And Prostate Cancer

Plasma insulin-like growth factor-1 and binding protein-3 and subsequent risk of prostate cancer in the PSA era

2005 ◽  
Vol 16 (3) ◽  
pp. 255-262 ◽  
Author(s):  
Elizabeth A. Platz ◽  
Michael N. Pollak ◽  
Michael F. Leitzmann ◽  
Meir J. Stampfer ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Plasma Insulin ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Subsequent Risk

Measurement of insulin-like growth factor axis does not enhance specificity of PSA-based prostate cancer screening

Urology ◽  
2004 ◽  
Vol 64 (2) ◽  
pp. 317-322 ◽  
Author(s):  
Steven E Oliver ◽  
Jeff Holly ◽  
Tim J Peters ◽  
Jenny Donovan ◽  
Raj Persad ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Screening ◽  
Growth Factor ◽  
Prostate Cancer Screening ◽  
Insulin Like Growth Factor

scholarly journals Influence of low- and high-protein diets on insulin and insulin-like growth factor-1 binding to skeletal muscle and liver in the growing rat

1991 ◽  
Vol 65 (1) ◽  
pp. 47-60 ◽  
Author(s):  
D. Dardevet ◽  
M. Manin ◽  
M. Balage ◽  
C. Sornet ◽  
J. Grizard
Keyword(s):  
Skeletal Muscle ◽  
Growth Factor ◽  
Dietary Protein ◽  
Binding Capacity ◽  
Plasma Concentrations ◽  
Insulin Binding ◽  
Metabolic Adaptation ◽  
Scatchard Analysis ◽  
Insulin Like Growth Factor ◽  
Hormone Binding

The influence of protein content of the diet on the plasma concentrations and binding to skeletal muscle and liver of insulin and insulin-like growth factor-1 (IGF-1), was studied in growing rats. Animals with a starting body-weight of 80 g received for an 11 d period isoenergetic diets containing (g/kg dry matter) 155 protein as controls (MP), or 55 (LP) or 300 (HP) protein. Food was offered as six equal meals/d. Daily food intakes provided adequate amounts of energy. Total plasma IGF-1 increased linearly as a function of dietary protein intake. Plasma insulin was lower in the LP than in the MP and HP groups. Hormone binding was studied in wheat-germ agglutinin (WGA) partially purified skeletal muscle receptor preparations. Each 125I-labelled hormone binding was competed for by increasing amounts of homologous and heterologous unlabelled hormone; this displacement needed lower concentrations of homologous than heterologous hormone. When compared with MP-diet feeding, the LP diet resulted in an increased ligand concentration for half-maximal binding. In addition the specific 125I-labelled insulin and 125I-labelled IGF-1 binding increased at all hormone concentrations and, as revealed by Scatchard analysis, the hormone binding capacity also rose (only significant for low-affinity insulin receptors and high-affinity IGF-1 receptors). The HP diet had little effect on hormone binding, except to increase insulin binding at very low insulin concentrations. Hormone binding was further studied in WGA partially purified liver receptor preparations. Those preparations did not exhibit any detectable specific 125I-labelled IGF-1 binding. The specific 125I-labelled insulin binding was not altered by dietary protein level. It is concluded that the increase in skeletal muscle insulin and IGF-1 binding along with a decrease in insulin and IGF-1 in the blood from rats fed on the LP diet, is consistent with the concept of an inverse relationship between plasma hormone and hormone binding. The physiological significance with respect to metabolic adaptation of muscle remains to be established

scholarly journals Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Norihiko Tsuchiya ◽  
Shintaro Narita ◽  
Takamitsu Inoue ◽  
Mitsuru Saito ◽  
Kazuyuki Numakura ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Growth Factor ◽  
Bone Metastasis ◽  
Cancer Patients ◽  
Initial Diagnosis ◽  
Insulin Like Growth Factor
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