Human liver carboxylesterase 1 outperforms alpha-fetoprotein as biomarker to discriminate hepatocellular carcinoma from other liver diseases in Korean patients

2013 ◽  
Vol 133 (2) ◽  
pp. 408-415 ◽  
Author(s):  
Keun Na ◽  
Seul-Ki Jeong ◽  
Min Jung Lee ◽  
Sang Yun Cho ◽  
Sun A Kim ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Diseases ◽  
Human Liver ◽  
Alpha Fetoprotein ◽  
Korean Patients ◽  
Carboxylesterase 1

Evaluation of lectin-reactive alpha-fetoprotein in patients with hepatocellular carcinoma and chronic liver diseases

1998 ◽  
Vol 114 ◽  
pp. A621
Author(s):  
Vu Van Khien ◽  
Ha Van Mao ◽  
Tran Thi Chinh ◽  
Pham Thu Ha ◽  
Bui Van Lac ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Diseases ◽  
Alpha Fetoprotein ◽  
Chronic Liver ◽  
Chronic Liver Diseases

Clinical Evaluation of Lentil Lectin-Reactive Alpha-Fetoprotein-L3 in Histology-Proven Hepatocellular Carcinoma

2001 ◽  
Vol 16 (2) ◽  
pp. 105-111 ◽  
Author(s):  
V.V. Khien ◽  
H.V. Mao ◽  
T.T. Chinh ◽  
P.T. Ha ◽  
M.H. Bang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Diseases ◽  
Alpha Fetoprotein ◽  
Chronic Liver ◽  
Chronic Liver Diseases ◽  
Antibody Affinity ◽  
Lectin Affinity ◽  
Affinity Electrophoresis ◽  
Lentil Lectin ◽  
The Mean

Introduction Serum alpha-fetoprotein (AFP) is a useful marker of hepatocellular carcinoma (HCC), although the serum AFP concentration is also increased in patients with chronic liver diseases (CLD). The analysis of AFP glycoforms has been known to be of diagnostic value. We applied the lectin-affinity electrophoresis and antibody-affinity blotting techniques to HCC patients in Vietnam in order to better understand the role of lentil lectin-affinity AFP-L3 in the diagnosis and differential diagnosis of HCC, and its relationship with the biological characteristics of HCC. Methods Lens culinaris agglutinin-reactive AFP (AFP-L3) was measured in 65 patients with histologically proven HCC and 25 patients with CLD. All patients had serum AFP levels above 54 ng/mL. AFP-L3 levels were determined by lectin affinity electrophoresis coupled with antibody-affinity blotting. The diagnosis of HCC was confirmed histologically by ultrasound-guided biopsy. Results The mean value of AFP-L3 in the HCC patients was 49.6 ± 21.6%, which was significantly higher (p<0.001) than that in the 25 CLD patients (10.7 ± 4.3%). When the cutoff level for AFP-L3 was set at 15% (mean ± SD), the sensitivity was 96.9%, the specificity 92.0% and the accuracy 95.5% in the 65 HCC patients. There was no clear correlation between serum AFP level and AFP-L3 percentage (r=0.16). There was no correlation between AFP-L3 and the maximum diameter of HCC nodules (r=0.05). However, the mean AFP-L3 value was higher in moderately or poorly differentiated HCC than in well differentiated tumors (p<0.001). Conclusions AFP-L3 is potentially a clinically useful marker for the differentiation of increased AFP levels in hepatocellular carcinoma and chronic liver diseases. The AFP-L3 percentage is closely related to HCC differentiation. We consider the analysis of AFP-L3 a useful adjunct in the diagnosis of HCC.

scholarly journals The identification of stem cells in human liver diseases and hepatocellular carcinoma

2010 ◽  
Vol 88 (3) ◽  
pp. 331-340 ◽  
Author(s):  
Joan Oliva ◽  
Barbara A. French ◽  
X. Qing ◽  
Samuel W. French
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Liver Diseases ◽  
Human Liver

scholarly journals Molecular Profiling of Hepatocellular Carcinoma in Mice with a Chronic Deficiency of HepaticS-Adenosylmethionine:  Relevance in Human Liver Diseases

2006 ◽  
Vol 5 (4) ◽  
pp. 944-953 ◽  
Author(s):  
Enrique Santamaría ◽  
Javier Muñoz ◽  
Joaquín Fernández-Irigoyen ◽  
Laura Sesma ◽  
María I. Mora ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Diseases ◽  
Human Liver ◽  
Molecular Profiling

Expression of MAGE, GAGE and BAGE genes in human liver diseases: utility as molecular markers for hepatocellular carcinoma

2000 ◽  
Vol 32 (4) ◽  
pp. 612-617 ◽  
Author(s):  
Yoshiyuki Kobayashi ◽  
Toshihiro Higashi ◽  
Kazuhiro Nouso ◽  
Harushige Nakatsukasa ◽  
Masahiko Ishizaki ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Markers ◽  
Liver Diseases ◽  
Human Liver
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