scholarly journals Macrophage migration inhibitory factor induces epithelial to mesenchymal transition, enhances tumor aggressiveness and predicts clinical outcome in resected pancreatic ductal adenocarcinoma

2012 ◽  
Vol 132 (4) ◽  
pp. 785-794 ◽  
Author(s):  
Naotake Funamizu ◽  
Chaoxin Hu ◽  
Curtis Lacy ◽  
Aaron Schetter ◽  
Geng Zhang ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Epithelial To Mesenchymal Transition ◽  
Inhibitory Factor ◽  
Ductal Adenocarcinoma ◽  
Macrophage Migration ◽  
Tumor Aggressiveness ◽  
Mesenchymal Transition

Astragalus Polysaccharide (PG2) Suppresses Macrophage Migration Inhibitory Factor and Aggressiveness of Lung Adenocarcinoma Cells

2020 ◽  
Vol 48 (06) ◽  
pp. 1491-1509
Author(s):  
Chien-Huang Liao ◽  
Chen-Yin Yong ◽  
Gi-Ming Lai ◽  
Jyh-Ming Chow ◽  
Chieh-Fang Cheng ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Cancer Cells ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
A549 Cells ◽  
Scid Mice ◽  
Inhibitory Factor ◽  
Migration And Invasion ◽  
Macrophage Migration ◽  
Mesenchymal Transition

Astragalus membranaceus is the most popular traditional Chinese medicine for managing vital energy deficiency. Its injectable polysaccharide PG2 has been used for relieving cancer-related fatigue, and PG2 has immune-modulatory and anti-inflammatory effects. In this study, we explored the effects of PG2 in lung adenocarcinoma A549 and CL1-2 cells and investigated its anticancer activity, and the results were validated in severe combined immunodeficiency (SCID) mice. Although PG2 did not inhibit the growth of these cells, it dose-dependently suppressed their migration and invasion, accompanied by reduced vimentin and AXL and induced epithelial cadherin (E-cadherin) expression. Regarding the underlying molecular mechanism, PG2 treatment reduced the macrophage migration inhibitory factor (MIF), an inflammatory cytokine that promotes the epithelial–mesenchymal transition and aggressiveness of cancer cells. Consistent with the previous finding that MIF regulates matrix metalloproteinase-13 (MMP-13) and AMP-activated protein kinase (AMPK), treatment with PG2 reduced MMP-13 and activated AMPK in A549 and CL1-2 cells in this study. In SCID mice injected with A549 cells through the tail vein, intraperitoneal injection with PG2 reduced lung and abdominal metastases in parallel with decreased immunohistochemical staining of AXL, vimentin, MMP-13, and MIF in the tumor. Collectively, data revealed a potential application of PG2 in integrative cancer treatment through the suppression of MIF in cancer cells and their aggressiveness.

287: Macrophage Migration Inhibitory Factor and its Receptor CD74 are Upregulated in the Urothelium of Interstitial Cystitis Patients

2006 ◽  
Vol 175 (4S) ◽  
pp. 95-96 ◽  
Author(s):  
Pedro L. Vera ◽  
Kenneth A. lczkowski ◽  
Robert M. Moldwin ◽  
Leslie Kushner ◽  
Katherine L. Meyer-Siegler
Keyword(s):  
Interstitial Cystitis ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Inhibitory Factor ◽  
Macrophage Migration
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