Persistent activation of pancreatic stellate cells creates a microenvironment favorable for the malignant behavior of pancreatic ductal adenocarcinoma

2012 ◽  
Vol 132 (5) ◽  
pp. 993-1003 ◽  
Author(s):  
Dong Tang ◽  
Daorong Wang ◽  
Zhongxu Yuan ◽  
Xiaofeng Xue ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma ◽  
Malignant Behavior

Activated pancreatic stellate cells inhibit CD8+ infiltrate in pancreatic ductal adenocarcinoma via CXCL12

Pancreatology ◽  
2013 ◽  
Vol 13 (1) ◽  
pp. e10
Author(s):  
Abasi Ene-Obong ◽  
Andrew J. Clear ◽  
Alan G. Ramsay ◽  
Hemant M. Kocher
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma

Pancreatic stellate cells are immunosuppressive modulators in pancreatic ductal adenocarcinoma

Pancreatology ◽  
2012 ◽  
Vol 12 (5) ◽  
pp. e3-e4
Author(s):  
Christine Feig ◽  
James O. Jones ◽  
Richard J.B. Wells ◽  
David A. Tuveson ◽  
Douglas T. Fearon
Keyword(s):  
Pancreatic Ductal Adenocarcinoma ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma

scholarly journals The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives

2021 ◽  
Vol 10 ◽  
Author(s):  
Yang Wu ◽  
Chun Zhang ◽  
Kuirong Jiang ◽  
Jens Werner ◽  
Alexandr V. Bazhin ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma ◽  
Gastrointestinal Malignancy ◽  
Desmoplastic Reaction ◽  
Pancreatic Cancer Cells ◽  
Promising Strategy

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furthermore, the crosstalk among PSCs, pancreatic cancer cells (PCCs) as well as other stroma cells can establish a growth-supportive tumor microenvironment (TME) of PDAC, thereby enhancing tumor growth, metastasis, and chemoresistance via various pathways. Recently, targeting stroma has emerged as a promising strategy for PDAC therapy, and several novel strategies have been proposed. The aim of our study is to give a profound review of the role of PSCs in PDAC progression and recent advances in stroma-targeting strategies.

AB025. S025. Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma

2018 ◽  
Vol 1 (1) ◽  
pp. AB025-AB025
Author(s):  
Kazuhiro Koikawa ◽  
Kenoki Ohuchida ◽  
Yohei Ando ◽  
Shin Kibe ◽  
Hiromichi Nakayama ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Stellate Cells ◽  
Pancreatic Stellate Cells ◽  
Ductal Adenocarcinoma ◽  
Local Invasion
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